U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

ZNF280B zinc finger protein 280B [ Homo sapiens (human) ]

Gene ID: 140883, updated on 2-Nov-2024

Summary

Go to the top of the page Help
Official Symbol
ZNF280Bprovided by HGNC
Official Full Name
zinc finger protein 280Bprovided by HGNC
Primary source
HGNC:HGNC:23022
See related
Ensembl:ENSG00000275004 AllianceGenome:HGNC:23022
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
SUHW2; ZNF279; ZNF632; 5'OY11.1; D87009.C22.3
Summary
The protein encoded by this gene is a transcription factor that upregulates expression of MDM2, which negatively regulates p53 expression. This gene is highly expressed in prostate cancer cells, which leads to a reduction in p53 levels and an increase in growth of the cancer cells. Several transcript variants have been found for this gene, but only one of them is protein-coding. [provided by RefSeq, Jan 2015]
Expression
Biased expression in testis (RPKM 11.7), brain (RPKM 1.5) and 4 other tissues See more
Orthologs
mouse all
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

Go to the top of the page Help
See ZNF280B in Genome Data Viewer
Location:
22q11.22
Exon count:
8
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 22 NC_000022.11 (22484421..22509154, complement)
RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 22 NC_060946.1 (22907263..22932010, complement)
RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 22 NC_000022.10 (22838767..22863060, complement)

Chromosome 22 - NC_000022.11Genomic Context describing neighboring genes Neighboring gene immunoglobulin lambda locus Neighboring gene immunoglobulin lambda variable 7-35 (pseudogene) Neighboring gene ASH2L pseudogene 4 Neighboring gene uncharacterized LOC124905161 Neighboring gene BRD4-independent group 4 enhancer GRCh37_chr22:22874253-22875452 Neighboring gene ReSE screen-validated silencer GRCh37_chr22:22896585-22896782 Neighboring gene IGL region enhancer-blocking element 22-2 Neighboring gene zinc finger protein 280A Neighboring gene PRAME nuclear receptor transcriptional regulator

Genomic regions, transcripts, and products

Go to the top of the page Help

Go to nucleotide: Graphics FASTA GenBank

Expression

Go to the top of the page Help
  • Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

Go to the top of the pageHelp

Related articles in PubMed

  1. Zinc Finger 280B regulates sGCα1 and p53 in prostate cancer cells. Gao S, et al. PLoS One, 2013. PMID 24236047, Free PMC Article
  2. A genome-wide search for loci interacting with known prostate cancer risk-associated genetic variants. Tao S, et al. Carcinogenesis, 2012 Mar. PMID 22219177, Free PMC Article
  3. Isolation of novel and known genes from a human fetal cochlear cDNA library using subtractive hybridization and differential screening. Robertson NG, et al. Genomics, 1994 Sep 1. PMID 7829101
  4. One-megabase sequence analysis of the human immunoglobulin lambda gene locus. Kawasaki K, et al. Genome Res, 1997 Mar. PMID 9074928
  5. Mutations of the Transcriptional Corepressor ZMYM2 Cause Syndromic Urinary Tract Malformations. Connaughton DM, et al. Am J Hum Genet, 2020 Oct 1. PMID 32891193, Free PMC Article

See all (15) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. ZNF280B upregulates GUCY1A3 expression and downregulates TP53 in prostate cancer cells.
    Title: Zinc Finger 280B regulates sGCα1 and p53 in prostate cancer cells.
Submit: New GeneRIF Correction

Phenotypes

Go to the top of the page Help

Review eQTL and phenotype association data in this region using PheGenI

EBI GWAS Catalog

Description
A genome-wide search for loci interacting with known prostate cancer risk-associated genetic variants.
EBI GWAS Catalog

Variation

Go to the top of the page Help

See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

Interactions

Go to the top of the page Help
Products Interactant Other Gene Complex Source Pubs Description

General gene information

Go to the top of the page Help

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables DNA-binding transcription factor activity, RNA polymerase II-specific IBA
Inferred from Biological aspect of Ancestor
more info
  
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in regulation of DNA-templated transcription IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in regulation of transcription by RNA polymerase II IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  

General protein information

Go to the top of the page Help
Preferred Names
zinc finger protein 280B
Names
suppressor of hairy wing homolog 2
zinc finger protein 279
zinc finger protein 632

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_000002.1 

    Range
    462755..487493 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_080764.4 → NP_542942.2  zinc finger protein 280B

    See identical proteins and their annotated locations for NP_542942.2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) is the protein-coding variant.
    Source sequence(s)
    AC245291, AK097608, AW021601
    Consensus CDS
    CCDS13799.1
    UniProtKB/Swiss-Prot
    Q86YH2
    UniProtKB/TrEMBL
    A0A0D9SEJ8, B3KUN2
    Related
    ENSP00000485750.1, ENST00000626650.3
    Conserved Domains (2) summary
    sd00017
    Location:345 → 366
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam13836
    Location:45 → 225
    DUF4195; Domain of unknown function (DUF4195)

RNA

  1. NR_130642.2 RNA Sequence

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) lacks an alternate segment in the 3' end compared to variant 1. This variant is represented as non-coding because the use of the 5'-most expected translational start codon, as used in variant 1, renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
    Source sequence(s)
    AC245291, AK097608, AW021601, BC040020

  2. NR_130643.2 RNA Sequence

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) lacks an exon in the 5' end and uses an alternate splice junction at the 5' end of the last exon compared to variant 1. This variant is represented as non-coding because it lacks the entire coding region found in variant 1.
    Source sequence(s)
    AC245291, AW021601, BI523641

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000022.11 Reference GRCh38.p14 Primary Assembly

    Range
    22484421..22509154 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_047441144.1 → XP_047297100.1  zinc finger protein 280B isoform X1

    UniProtKB/Swiss-Prot
    Q86YH2
    UniProtKB/TrEMBL
    A0A0D9SEJ8

  2. XM_047441146.1 → XP_047297102.1  zinc finger protein 280B isoform X1

    UniProtKB/Swiss-Prot
    Q86YH2
    UniProtKB/TrEMBL
    A0A0D9SEJ8

  3. XM_047441143.1 → XP_047297099.1  zinc finger protein 280B isoform X1

    UniProtKB/Swiss-Prot
    Q86YH2
    UniProtKB/TrEMBL
    A0A0D9SEJ8
    Related
    ENSP00000481008.1, ENST00000613655.1

  4. XM_047441145.1 → XP_047297101.1  zinc finger protein 280B isoform X1

    UniProtKB/Swiss-Prot
    Q86YH2
    UniProtKB/TrEMBL
    A0A0D9SEJ8

  5. XM_011529897.3 → XP_011528199.1  zinc finger protein 280B isoform X1

    See identical proteins and their annotated locations for XP_011528199.1

    UniProtKB/Swiss-Prot
    Q86YH2
    UniProtKB/TrEMBL
    A0A0D9SEJ8, B3KUN2
    Conserved Domains (2) summary
    sd00017
    Location:345 → 366
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam13836
    Location:45 → 225
    DUF4195; Domain of unknown function (DUF4195)

Reference GRCh38.p14 ALT_REF_LOCI_1

Genomic

  1. NT_187629.1 Reference GRCh38.p14 ALT_REF_LOCI_1

    Range
    120078..144822 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054329445.1 → XP_054185420.1  zinc finger protein 280B isoform X1

    UniProtKB/Swiss-Prot
    Q86YH2
    UniProtKB/TrEMBL
    A0A0D9SEJ8

  2. XM_054329444.1 → XP_054185419.1  zinc finger protein 280B isoform X1

    UniProtKB/Swiss-Prot
    Q86YH2
    UniProtKB/TrEMBL
    A0A0D9SEJ8

  3. XM_054329447.1 → XP_054185422.1  zinc finger protein 280B isoform X1

    UniProtKB/Swiss-Prot
    Q86YH2
    UniProtKB/TrEMBL
    A0A0D9SEJ8

  4. XM_054329446.1 → XP_054185421.1  zinc finger protein 280B isoform X1

    UniProtKB/Swiss-Prot
    Q86YH2
    UniProtKB/TrEMBL
    A0A0D9SEJ8

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060946.1 Alternate T2T-CHM13v2.0

    Range
    22907263..22932010 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054325109.1 → XP_054181084.1  zinc finger protein 280B isoform X1

    UniProtKB/Swiss-Prot
    Q86YH2
    UniProtKB/TrEMBL
    A0A0D9SEJ8

  2. XM_054325108.1 → XP_054181083.1  zinc finger protein 280B isoform X1

    UniProtKB/Swiss-Prot
    Q86YH2
    UniProtKB/TrEMBL
    A0A0D9SEJ8

  3. XM_054325111.1 → XP_054181086.1  zinc finger protein 280B isoform X1

    UniProtKB/Swiss-Prot
    Q86YH2
    UniProtKB/TrEMBL
    A0A0D9SEJ8

  4. XM_054325110.1 → XP_054181085.1  zinc finger protein 280B isoform X1

    UniProtKB/Swiss-Prot
    Q86YH2
    UniProtKB/TrEMBL
    A0A0D9SEJ8
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q86YH2.3 GenPept UniProtKB/Swiss-Prot:Q86YH2

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

Chemical Information
Molecular Biology Databases
Research Materials
Tools