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Pde11a phosphodiesterase 11A [ Rattus norvegicus (Norway rat) ]

Gene ID: 140928, updated on 18-Sep-2024

Summary

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Official Symbol
Pde11aprovided by RGD
Official Full Name
phosphodiesterase 11Aprovided by RGD
Primary source
RGD:621793
See related
EnsemblRapid:ENSRNOG00000024457 AllianceGenome:RGD:621793
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary
Enables cyclic-nucleotide phosphodiesterase activity. Involved in negative regulation of cAMP-mediated signaling and negative regulation of cGMP-mediated signaling. Located in perikaryon. Human ortholog(s) of this gene implicated in primary pigmented nodular adrenocortical disease. Orthologous to human PDE11A (phosphodiesterase 11A). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in Testes (RPKM 28.2), Kidney (RPKM 22.0) and 5 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Pde11a in Genome Data Viewer
Location:
3q23-q24
Exon count:
25
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 3 NC_086021.1 (81320822..81704397, complement)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 3 NC_051338.1 (60913562..61297154, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 3 NC_005102.4 (62818502..63211843, complement)

Chromosome 3 - NC_086021.1Genomic Context describing neighboring genes Neighboring gene intraflagellar transport 70A2 Neighboring gene intraflagellar transport 70A1 Neighboring gene uncharacterized LOC120101579 Neighboring gene uncharacterized LOC134486390 Neighboring gene uncharacterized LOC120101580 Neighboring gene acidic nuclear phosphoprotein 32 family member A, pseudogene 1 Neighboring gene cytochrome c, testis Neighboring gene RNA binding motif protein 45 Neighboring gene oxysterol binding protein-like 6

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. N-Terminal domain of phosphodiesterase-11A4 (PDE11A4) decreases affinity of the catalytic site for substrates and tadalafil, and is involved in oligomerization. Weeks JL 2nd, et al. Biochemistry, 2007 Sep 11. PMID 17696499
  2. Identification of rat cyclic nucleotide phosphodiesterase 11A (PDE11A): comparison of rat and human PDE11A splicing variants. Yuasa K, et al. Eur J Biochem, 2001 Aug. PMID 11502204
  3. PDE9A, PDE10A, and PDE11A expression in rat trigeminovascular pain signalling system. Kruse LS, et al. Brain Res, 2009 Jul 24. PMID 19445908
  4. Structure and expression of rodent genes encoding the testis-specific cytochrome c. Differences in gene structure and evolution between somatic and testicular variants. Virbasius JV, et al. J Biol Chem, 1988 May 15. PMID 2834389
  5. Binding of cyclic nucleotides to phosphodiesterase 10A and 11A GAF domains does not stimulate catalytic activity. Matthiesen K, et al. Biochem J, 2009 Oct 12. PMID 19689430

See all (8) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables 3',5'-cGMP-stimulated cyclic-nucleotide phosphodiesterase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables 3',5'-cGMP-stimulated cyclic-nucleotide phosphodiesterase activity IEA
Inferred from Electronic Annotation
more info
  
enables 3',5'-cGMP-stimulated cyclic-nucleotide phosphodiesterase activity ISO
Inferred from Sequence Orthology
more info
  
enables 3',5'-cGMP-stimulated cyclic-nucleotide phosphodiesterase activity ISS
Inferred from Sequence or Structural Similarity
more info
  
enables 3',5'-cyclic-AMP phosphodiesterase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables 3',5'-cyclic-GMP phosphodiesterase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables cGMP binding IEA
Inferred from Electronic Annotation
more info
  
enables cGMP binding ISO
Inferred from Sequence Orthology
more info
  
enables calmodulin-activated 3',5'-cyclic-GMP phosphodiesterase activity IEA
Inferred from Electronic Annotation
more info
  
enables calmodulin-activated dual specificity 3',5'-cyclic-GMP, 3',5'-cyclic-AMP phosphodiesterase activity IEA
Inferred from Electronic Annotation
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in cAMP-mediated signaling IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in negative regulation of cAMP-mediated signaling IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in negative regulation of cAMP/PKA signal transduction IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in negative regulation of cGMP-mediated signaling IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in negative regulation of cGMP-mediated signaling IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in signal transduction IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in cytosol IEA
Inferred from Electronic Annotation
more info
  
located_in perikaryon IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
dual 3',5'-cyclic-AMP and -GMP phosphodiesterase 11A
Names
cAMP and cGMP phosphodiesterase 11A
NP_001120952.1
NP_001120953.1
NP_543169.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001127480.2 → NP_001120952.1  dual 3',5'-cyclic-AMP and -GMP phosphodiesterase 11A isoform 3

    See identical proteins and their annotated locations for NP_001120952.1

    Status: PROVISIONAL

    Description
    Transcript Variant: This variant (3), also known as PDE11A3, contains a distinct 5' UTR and 5' coding region, compared to variant 4. The resulting isoform (3) contains a shorter and distinct N-terminus, compared to isoform 4.
    Source sequence(s)
    JAXUCZ010000003
    UniProtKB/Swiss-Prot
    Q8VID6
    Conserved Domains (2) summary
    smart00065
    Location:152 → 318
    GAF; Domain present in phytochromes and cGMP-specific phosphodiesterases
    pfam00233
    Location:413 → 648
    PDEase_I; 3'5'-cyclic nucleotide phosphodiesterase

  2. NM_001127481.3 → NP_001120953.1  dual 3',5'-cyclic-AMP and -GMP phosphodiesterase 11A isoform 2

    See identical proteins and their annotated locations for NP_001120953.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2), also known as PDE11A2, contains a distinct 5' UTR and 5' coding region, compared to variant 4. The resulting isoform (2) has a shorter and distinct N-terminus, compared to isoform 4.
    Source sequence(s)
    JAXUCZ010000003
    UniProtKB/Swiss-Prot
    Q8VID6
    Related
    ENSRNOP00000048657.2, ENSRNOT00000045862.4
    Conserved Domains (2) summary
    smart00065
    Location:48 → 214
    GAF; Domain present in phytochromes and cGMP-specific phosphodiesterases
    pfam00233
    Location:309 → 544
    PDEase_I; 3'5'-cyclic nucleotide phosphodiesterase

  3. NM_080893.2 → NP_543169.1  dual 3',5'-cyclic-AMP and -GMP phosphodiesterase 11A isoform 4

    See identical proteins and their annotated locations for NP_543169.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (4), also known as PDE11A4, represents the longest transcript and encodes the longest protein (isoform 4).
    Source sequence(s)
    JAXUCZ010000003
    UniProtKB/Swiss-Prot
    Q8VID6, Q8VID7, Q8VID8
    UniProtKB/TrEMBL
    A0A8L2Q3C3
    Related
    ENSRNOP00000008300.6, ENSRNOT00000008301.8
    Conserved Domains (2) summary
    smart00065
    Location:217 → 380
    GAF; Domain present in phytochromes and cGMP-specific phosphodiesterases
    pfam00233
    Location:663 → 898
    PDEase_I; 3'5'-cyclic nucleotide phosphodiesterase

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086021.1 Reference GRCr8

    Range
    81320822..81704397 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q8VID6.1 GenPept UniProtKB/Swiss-Prot:Q8VID6

Gene LinkOut

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