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Lgr5 leucine rich repeat containing G protein coupled receptor 5 [ Mus musculus (house mouse) ]

Gene ID: 14160, updated on 4-Feb-2025

Summary

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Official Symbol
Lgr5provided by MGI
Official Full Name
leucine rich repeat containing G protein coupled receptor 5provided by MGI
Primary source
MGI:MGI:1341817
See related
Ensembl:ENSMUSG00000020140 AllianceGenome:MGI:1341817
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
FEX; Gpr49
Summary
The protein encoded by this gene is a leucine-rich repeat-containing receptor (LGR) and member of the G protein-coupled, 7-transmembrane receptor (GPCR) superfamily. The encoded protein is a receptor for R-spondins and is involved in the canonical Wnt signaling pathway. This protein plays a role in the formation and maintenance of adult intestinal stem cells during postembryonic development. [provided by RefSeq, Sep 2015]
Expression
Broad expression in frontal lobe adult (RPKM 8.3), limb E14.5 (RPKM 3.7) and 18 other tissues See more
Orthologs
human all
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Genomic context

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See Lgr5 in Genome Data Viewer
Location:
10 D2; 10 63.51 cM
Exon count:
18
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 10 NC_000076.7 (115286219..115423685, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 10 NC_000076.6 (115450314..115587780, complement)

Chromosome 10 - NC_000076.7Genomic Context describing neighboring genes Neighboring gene STARR-positive B cell enhancer ABC_E1128 Neighboring gene predicted gene, 53633 Neighboring gene THAP domain containing, apoptosis associated protein 2 Neighboring gene zinc finger, C3H1-type containing Neighboring gene STARR-positive B cell enhancer mm9_chr10:114916114-114916415 Neighboring gene STARR-seq mESC enhancer starr_27944 Neighboring gene RIKEN cDNA A930009A15 gene Neighboring gene ribosomal protein S3A pseudogene Neighboring gene STARR-seq mESC enhancer starr_27945 Neighboring gene STARR-seq mESC enhancer starr_27946 Neighboring gene STARR-seq mESC enhancer starr_27947 Neighboring gene RIKEN cDNA 4930422I22 gene Neighboring gene tetraspanin 8

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Stem cell plasticity enables hair regeneration following Lgr5(+) cell loss. Hoeck JD, et al. Nat Cell Biol, 2017 Jun. PMID 28553937
  2. Identification of a cKit(+) colonic crypt base secretory cell that supports Lgr5(+) stem cells in mice. Rothenberg ME, et al. Gastroenterology, 2012 May. PMID 22333952, Free PMC Article
  3. Enteroid Monolayers Reveal an Autonomous WNT and BMP Circuit Controlling Intestinal Epithelial Growth and Organization. Thorne CA, et al. Dev Cell, 2018 Mar 12. PMID 29503158, Free PMC Article
  4. Effect of essential amino acids on enteroids: Methionine deprivation suppresses proliferation and affects differentiation in enteroid stem cells. Saito Y, et al. Biochem Biophys Res Commun, 2017 Jun 17. PMID 28483523
  5. Spasmolytic polypeptide-expressing metaplasia (SPEM) in the gastric oxyntic mucosa does not arise from Lgr5-expressing cells. Nam KT, et al. Gut, 2012 Dec. PMID 22198711, Free PMC Article

See all (741) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Helicobacter pylori induces the expression of Lgr5 and stem cell properties in gastric target cells.
    Title: Helicobacter pylori induces the expression of Lgr5 and stem cell properties in gastric target cells.
  2. Loss of Hepatic Leucine-Rich Repeat-Containing G-Protein Coupled Receptors 4 and 5 Promotes Nonalcoholic Fatty Liver Disease.
    Title: Loss of Hepatic Leucine-Rich Repeat-Containing G-Protein Coupled Receptors 4 and 5 Promotes Nonalcoholic Fatty Liver Disease.
  3. Study on Lgr5 expression in pancreas tissues and organoids by lineage tracing.
    Title: Study on Lgr5 expression in pancreas tissues and organoids by lineage tracing.
  4. ANKRD22 Drives Rapid Proliferation of Lgr5(+) Cells and Acts as a Promising Therapeutic Target in Gastric Mucosal Injury.
    Title: ANKRD22 Drives Rapid Proliferation of Lgr5(+) Cells and Acts as a Promising Therapeutic Target in Gastric Mucosal Injury.
  5. IL-17RA-signaling in Lgr5(+) intestinal stem cells induces expression of transcription factor ATOH1 to promote secretory cell lineage commitment.
    Title: IL-17RA-signaling in Lgr5(+) intestinal stem cells induces expression of transcription factor ATOH1 to promote secretory cell lineage commitment.
  6. PTEN-mediated AKT/beta-catenin signaling enhances the proliferation and expansion of Lgr5+ hepatocytes.
    Title: PTEN-mediated AKT/β-catenin signaling enhances the proliferation and expansion of Lgr5+ hepatocytes.
  7. Lgr5 Marks Adult Progenitor Cells Contributing to Skeletal Muscle Regeneration and Sarcoma Formation.
    Title: Lgr5 Marks Adult Progenitor Cells Contributing to Skeletal Muscle Regeneration and Sarcoma Formation.
  8. alphaSMA(+) fibroblasts suppress Lgr5(+) cancer stem cells and restrain colorectal cancer progression.
    Title: αSMA(+) fibroblasts suppress Lgr5(+) cancer stem cells and restrain colorectal cancer progression.
  9. Persistence of Lgr5+ colonic epithelial stem cells in mouse models of inflammatory bowel disease.
    Title: Persistence of Lgr5+ colonic epithelial stem cells in mouse models of inflammatory bowel disease.
  10. Lgr5-positive endothelial progenitor cells occupy a tumor and injury prone niche in the kidney vasa recta.
    Title: Lgr5-positive endothelial progenitor cells occupy a tumor and injury prone niche in the kidney vasa recta.
Submit: New GeneRIF Correction See all GeneRIFs (92)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
NOT enables G protein-coupled receptor activity ISS
Inferred from Sequence or Structural Similarity
more info
  
enables protein-hormone receptor activity IEA
Inferred from Electronic Annotation
more info
  
enables transmembrane signaling receptor activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables transmembrane signaling receptor activity ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in G protein-coupled receptor signaling pathway IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within epithelial cell proliferation involved in renal tubule morphogenesis IGI
Inferred from Genetic Interaction
more info
 PubMed 
acts_upstream_of_or_within hair follicle development IGI
Inferred from Genetic Interaction
more info
 PubMed 
acts_upstream_of_or_within inner ear development IDA
Inferred from Direct Assay
more info
 PubMed 
acts_upstream_of_or_within oocyte differentiation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in positive regulation of canonical Wnt signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in positive regulation of canonical Wnt signaling pathway IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in positive regulation of canonical Wnt signaling pathway ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within regulation of cell population proliferation IGI
Inferred from Genetic Interaction
more info
 PubMed 
Component Evidence Code Pubs
located_in Golgi apparatus ISO
Inferred from Sequence Orthology
more info
  
located_in nucleoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
  
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in plasma membrane ISO
Inferred from Sequence Orthology
more info
  
located_in plasma membrane ISS
Inferred from Sequence or Structural Similarity
more info
  
located_in trans-Golgi network membrane ISO
Inferred from Sequence Orthology
more info
  
located_in trans-Golgi network membrane ISS
Inferred from Sequence or Structural Similarity
more info
  

General protein information

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Preferred Names
leucine-rich repeat-containing G-protein coupled receptor 5
Names
G protein-coupled receptor 49
follicle expressed hormone
orphan G-protein coupled receptor FEX

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_010195.2 → NP_034325.2  leucine-rich repeat-containing G-protein coupled receptor 5 precursor

    Status: REVIEWED

    Source sequence(s)
    AK132387, BM935530
    Consensus CDS
    CCDS24180.1
    UniProtKB/Swiss-Prot
    Q3V1L2, Q9Z1P4
    UniProtKB/TrEMBL
    G3UXX4
    Related
    ENSMUSP00000020350.9, ENSMUST00000020350.15
    Conserved Domains (6) summary
    smart00013
    Location:33 → 70
    LRRNT; Leucine rich repeat N-terminal domain
    cd00116
    Location:88 → 386
    LRR_RI; Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond ...
    sd00031
    Location:354 → 375
    LRR_1; leucine-rich repeat [structural motif]
    sd00033
    Location:68 → 91
    LRR_RI; leucine-rich repeat [structural motif]
    pfam00001
    Location:575 → 820
    7tm_1; 7 transmembrane receptor (rhodopsin family)
    pfam13855
    Location:92 → 150
    LRR_8; Leucine rich repeat

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000076.7 Reference GRCm39 C57BL/6J

    Range
    115286219..115423685 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9Z1P4.2 GenPept UniProtKB/Swiss-Prot:Q9Z1P4

Gene LinkOut

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