Fgfr4 fibroblast growth factor receptor 4 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Fgfr4provided by MGI
Official Full Name: fibroblast growth factor receptor 4provided by MGI
Primary source: MGI:MGI:95525
See related: Ensembl:ENSMUSG00000005320 AllianceGenome:MGI:95525
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Fgfr-4
Summary: Predicted to enable fibroblast growth factor binding activity; fibroblast growth factor-activated receptor activity; and heparin binding activity. Involved in several processes, including cholesterol homeostasis; phosphate ion homeostasis; and regulation of bile acid biosynthetic process. Acts upstream of or within several processes, including alveolar secondary septum development; negative regulation of fibroblast growth factor production; and positive regulation of parathyroid hormone secretion. Predicted to be located in several cellular components, including Golgi apparatus; endoplasmic reticulum; and transport vesicle. Predicted to be part of receptor complex. Predicted to be integral component of plasma membrane. Predicted to colocalize with cell-cell junction. Is expressed in several structures, including alimentary system; brain; genitourinary system; musculoskeletal system; and sensory organ. Human ortholog(s) of this gene implicated in carcinoma (multiple); liver cirrhosis; prostate cancer; and stomach cancer. Orthologous to human FGFR4 (fibroblast growth factor receptor 4). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Biased expression in adrenal adult (RPKM 26.0), lung adult (RPKM 20.3) and 14 other tissues See more
Orthologs: human all
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Genomic context

Location:: 13 B1; 13 29.8 cM

Exon count:: 19

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	13	NC_000079.7 (55300631..55316572)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	13	NC_000079.6 (55152818..55168759)

Chromosome 13 - NC_000079.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Fibroblast growth factor receptor-4 mediates activation of Nuclear Factor Erythroid 2-Related Factor-2 in gastric tumorigenesis.
Title: Fibroblast growth factor receptor-4 mediates activation of Nuclear Factor Erythroid 2-Related Factor-2 in gastric tumorigenesis.
Up-Regulation of Astrocytic Fgfr4 Expression in Adult Mice after Spinal Cord Injury.
Title: Up-Regulation of Astrocytic Fgfr4 Expression in Adult Mice after Spinal Cord Injury.
Liver-specific FGFR4 knockdown in mice on an HFD increases bile acid synthesis and improves hepatic steatosis.
Title: Liver-specific FGFR4 knockdown in mice on an HFD increases bile acid synthesis and improves hepatic steatosis.
FGF21-FGFR4 signaling in cardiac myocytes promotes concentric cardiac hypertrophy in mouse models of diabetes.
Title: FGF21-FGFR4 signaling in cardiac myocytes promotes concentric cardiac hypertrophy in mouse models of diabetes.
Aberrant FGFR4 signaling worsens nonalcoholic steatohepatitis in FGF21KO mice.
Title: Aberrant FGFR4 signaling worsens nonalcoholic steatohepatitis in FGF21KO mice.
Homeobox B5 promotes metastasis and poor prognosis in Hepatocellular Carcinoma, via FGFR4 and CXCL1 upregulation.
Title: Homeobox B5 promotes metastasis and poor prognosis in Hepatocellular Carcinoma, via FGFR4 and CXCL1 upregulation.
Fibroblast growth factor 23 (FGF23) induces ventricular arrhythmias and prolongs QTc interval in mice in an FGF receptor 4-dependent manner.
Title: Fibroblast growth factor 23 (FGF23) induces ventricular arrhythmias and prolongs QTc interval in mice in an FGF receptor 4-dependent manner.
FGF23 induced left ventricular hypertrophy mediated by FGFR4 signaling in the myocardium is attenuated by soluble Klotho in mice.
Title: FGF23 induced left ventricular hypertrophy mediated by FGFR4 signaling in the myocardium is attenuated by soluble Klotho in mice.
FGFR4 does not contribute to progression of chronic kidney disease.
Title: FGFR4 does not contribute to progression of chronic kidney disease.
In mice receiving normal chow, the FGFR4 Arg385 allele was associated with elevated hepatic triglyceride content, altered hepatic lipid composition, and increased hepatic expression of genes inducing de novo lipogenesis and glycolysis. Body fat mass and distribution, glucose tolerance, and insulin sensitivity were unaltered. The FGFR4 Arg385 allele had no effect on glucose or lipid metabolism under the high-fat diet.
Title: The Gly385(388)Arg Polymorphism of the FGFR4 Receptor Regulates Hepatic Lipogenesis Under Healthy Diet.

Submit: New GeneRIF Correction See all GeneRIFs (49)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Chemically induced (ENU) (1)
Endonuclease-mediated (3)
Targeted (6) 1 citation

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

Fgfr4 (e-PCR), detects polymorphism
- UniSTS:143106

Fgfr4 (e-PCR), detects polymorphism
- UniSTS:508442

Fgfr4 (e-PCR), detects polymorphism
- UniSTS:508443

Fgfr4 (e-PCR), detects polymorphism
- UniSTS:507935

X59927 (e-PCR)
- UniSTS:160312

Fgfr4 (e-PCR), detects polymorphism
- UniSTS:547906

Fgfr4 (e-PCR), detects polymorphism
- UniSTS:480344

Fgfr4 (e-PCR), detects polymorphism
- UniSTS:463451

X59927 (e-PCR)
- UniSTS:163537

NoName (e-PCR)
- UniSTS:548574

Fgfr4 (e-PCR), detects polymorphism
- UniSTS:547831

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables ATP binding	IEA Inferred from Electronic Annotation more info
enables fibroblast growth factor binding	IBA Inferred from Biological aspect of Ancestor more info
enables fibroblast growth factor binding	ISO Inferred from Sequence Orthology more info
enables fibroblast growth factor receptor activity	IBA Inferred from Biological aspect of Ancestor more info
enables fibroblast growth factor receptor activity	ISO Inferred from Sequence Orthology more info
enables heparin binding	ISO Inferred from Sequence Orthology more info
enables kinase activity	IEA Inferred from Electronic Annotation more info
enables nucleotide binding	IEA Inferred from Electronic Annotation more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein kinase activity	IEA Inferred from Electronic Annotation more info
enables protein tyrosine kinase activity	IEA Inferred from Electronic Annotation more info
enables transferase activity	IEA Inferred from Electronic Annotation more info
enables transmembrane receptor protein tyrosine kinase activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within alveolar secondary septum development	IGI Inferred from Genetic Interaction more info	PubMed
involved_in cell migration	ISO Inferred from Sequence Orthology more info
involved_in cell surface receptor protein tyrosine kinase signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
involved_in cholesterol homeostasis	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within fibroblast growth factor receptor signaling pathway	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within fibroblast growth factor receptor signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in glucose homeostasis	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within lung development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in multicellular organism development	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within negative regulation of fibroblast growth factor production	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within negative regulation of gene expression	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within organ induction	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in peptidyl-tyrosine phosphorylation	ISO Inferred from Sequence Orthology more info
involved_in phosphate ion homeostasis	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within phosphorylation	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of DNA biosynthetic process	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of ERK1 and ERK2 cascade	IBA Inferred from Biological aspect of Ancestor more info
involved_in positive regulation of ERK1 and ERK2 cascade	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of catalytic activity	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within positive regulation of cell population proliferation	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within positive regulation of cell population proliferation	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of gene expression	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of kinase activity	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within positive regulation of parathyroid hormone secretion	IGI Inferred from Genetic Interaction more info	PubMed
involved_in positive regulation of proteolysis	ISO Inferred from Sequence Orthology more info
involved_in protein autophosphorylation	ISO Inferred from Sequence Orthology more info
involved_in protein phosphorylation	IEA Inferred from Electronic Annotation more info
involved_in regulation of bile acid biosynthetic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in regulation of bile acid biosynthetic process	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of bile acid biosynthetic process	ISO Inferred from Sequence Orthology more info
involved_in regulation of extracellular matrix disassembly	ISO Inferred from Sequence Orthology more info
involved_in regulation of lipid metabolic process	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within regulation of phosphate transport	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within regulation of phosphorus metabolic process	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within vitamin D3 metabolic process	IGI Inferred from Genetic Interaction more info	PubMed

Component	Evidence Code	Pubs
located_in Golgi apparatus	ISO Inferred from Sequence Orthology more info
colocalizes_with cell-cell junction	ISO Inferred from Sequence Orthology more info
located_in endoplasmic reticulum	ISO Inferred from Sequence Orthology more info
located_in endosome	IEA Inferred from Electronic Annotation more info
located_in membrane	IEA Inferred from Electronic Annotation more info
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in plasma membrane	ISO Inferred from Sequence Orthology more info
part_of receptor complex	IBA Inferred from Biological aspect of Ancestor more info
located_in transport vesicle	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: fibroblast growth factor receptor 4

Names: CTLA-2-beta protein; fibroblast growth factor receptor 4 16 minus form; protein-tyrosine kinase receptor MPK-11

NP_032037.2

EC 2.7.10.1

XP_006517162.3

EC 2.7.10.1

XP_006517163.1

EC 2.7.10.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_008011.2 → NP_032037.2 fibroblast growth factor receptor 4 precursor

See identical proteins and their annotated locations for NP_032037.2

Status: VALIDATED

Source sequence(s)

AK084850

Consensus CDS

CCDS26540.1

UniProtKB/Swiss-Prot

Q03142, Q27Q87, Q5J7D9, Q8C3V5, Q8CIB8

UniProtKB/TrEMBL

A0A0R4IZY3

Related

ENSMUSP00000005452.6, ENSMUST00000005452.6

Conserved Domains (6) summary

cd05099
Location:451 → 764

PTKc_FGFR4; Catalytic domain of the Protein Tyrosine Kinase, Fibroblast Growth Factor Receptor 4

cd05858
Location:261 → 348

Ig3_FGFR-2; Third immunoglobulin (Ig)-like domain of fibroblast growth factor receptor 2 (FGFR2)

smart00408
Location:47 → 104

IGc2; Immunoglobulin C-2 Type

smart00410
Location:159 → 238

IG_like; Immunoglobulin like

pfam07714
Location:464 → 740

Pkinase_Tyr; Protein tyrosine kinase

cl11960
Location:154 → 238

Ig; Immunoglobulin domain

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000079.7 Reference GRCm39 C57BL/6J

Range

55300631..55316572

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_006517099.3 → XP_006517162.3 fibroblast growth factor receptor 4 isoform X1

UniProtKB/Swiss-Prot

Q03142, Q27Q87, Q5J7D9, Q8C3V5, Q8CIB8

Conserved Domains (4) summary

cd05099
Location:481 → 794

PTKc_FGFR4; Catalytic domain of the Protein Tyrosine Kinase, Fibroblast Growth Factor Receptor 4

cd05858
Location:291 → 378

Ig3_FGFR-2; Third immunoglobulin (Ig)-like domain of fibroblast growth factor receptor 2 (FGFR2)

smart00408
Location:77 → 134

IGc2; Immunoglobulin C-2 Type

cl11960
Location:184 → 268

Ig; Immunoglobulin domain
XM_006517100.2 → XP_006517163.1 fibroblast growth factor receptor 4 isoform X2

Conserved Domains (2) summary

cd05099
Location:205 → 518

PTKc_FGFR4; Catalytic domain of the Protein Tyrosine Kinase, Fibroblast Growth Factor Receptor 4

cd05858
Location:15 → 102

Ig3_FGFR-2; Third immunoglobulin (Ig)-like domain of fibroblast growth factor receptor 2 (FGFR2)