Fv1 Friend virus susceptibility 1 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Fv1provided by MGI
Official Full Name: Friend virus susceptibility 1provided by MGI
Primary source: MGI:MGI:95595
See related: Ensembl:ENSMUSG00000070583 AllianceGenome:MGI:95595
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Rv1; Fv-1; Fv1d; Rv-1
Summary: Acts upstream of or within response to virus. Located in Golgi apparatus. Is expressed in several structures, including endocrine gland; ganglia; nasal cavity epithelium; submandibular gland primordium; and thymus primordium. [provided by Alliance of Genome Resources, Nov 2024]
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Genomic context

Location:: 4 E1; 4 78.56 cM

Exon count:: 1

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	4	NC_000070.7 (147953436..147954815)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	4	NC_000070.6 (147868979..147870358)

Chromosome 4 - NC_000070.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Patterns of Coevolutionary Adaptations across Time and Space in Mouse Gammaretroviruses and Three Restrictive Host Factors.
Title: Patterns of Coevolutionary Adaptations across Time and Space in Mouse Gammaretroviruses and Three Restrictive Host Factors.
Regions of Fv1 adapt cooperatively, highlighting its preference for repeated structures and suggesting that this functionally constrained aspect of the retroviral capsid lattice presents a common target in the evolution of intrinsic immunity.
Title: Evolutionary journey of the retroviral restriction gene Fv1.
data indicate that for some but not all Fv1 proteins, gain of restriction activities could be achieved by increasing the expression level of Fv1; however such a concentration dependent effect is not seen with most Fv1s and cannot explain the recently reported activities against non-MLVs
Title: Expression levels of Fv1: effects on retroviral restriction specificities.
These results support the hypothesis that Fv1 defended mice against waves of retroviral infection
Title: Evolution of the retroviral restriction gene Fv1: inhibition of non-MLV retroviruses.
The antiparallel organization of the NtD regions of Fv1 and Trim5alpha dimers correctly positions C-terminal specificity and N-terminal effector domains and facilitates stable binding to adjacent capsid hexamers in viral cores.
Title: Structural studies of postentry restriction factors reveal antiparallel dimers that enable avid binding to the HIV-1 capsid lattice.
Ordered assembly of murine leukemia virus capsid protein on lipid nanotubes directs specific binding by the restriction factor, Fv1.
Title: Ordered assembly of murine leukemia virus capsid protein on lipid nanotubes directs specific binding by the restriction factor, Fv1.
Virus with deletion of 114His in the capsid gene failed to replicate in Fv1-expressing cells.
Title: Generation and characterization of a stable full-length ecotropic murine leukemia virus molecular clone that produces novel phenotypes to Fv1 restriction.
defined the time point at which Fv1 interacts with virus and shown that it can work additively and independently of TRIM5; conclude that Fv1 and TRIM5 can both recognize retroviral particles early after cell entry and before reverse transcription
Title: Retroviral restriction factors Fv1 and TRIM5alpha act independently and can compete for incoming virus before reverse transcription.
A model for the arrangement of domains in Fv1 suggesting that dimerization of the N-terminal domain is necessary for Fv1 function to allow the protein to interact with multiple capsid protomers in retroviral cores was proposed.
Title: Characterization of an amino-terminal dimerization domain from retroviral restriction factor Fv1.
A variety of amino acid changes affecting Fv1 tropism were identified, at mouse leukemia virus CA protein positions 82, 92 to 95, 105, 114, and 117, and they all were mapped to the apparent exterior of virion-associated CA.
Title: Retroviral capsid determinants of Fv1 NB and NR tropism.

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General gene information

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Gene Ontology Provided by MGI

Process	Evidence Code	Pubs
involved_in defense response to virus	IEA Inferred from Electronic Annotation more info
involved_in response to virus	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within response to virus	IDA Inferred from Direct Assay more info	PubMed

Component	Evidence Code	Pubs
is_active_in Golgi apparatus	IBA Inferred from Biological aspect of Ancestor more info
located_in Golgi apparatus	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: Friend virus susceptibility protein 1

Names: Fv1 gammaretrovirus restriction factor; Fv1 restriction factor; Rauscher leukemia virus susceptibility 1; retrovirus restriction protein

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.