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Timm10b translocase of inner mitochondrial membrane 10B [ Mus musculus (house mouse) ]

Gene ID: 14356, updated on 9-Dec-2024

Summary

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Official Symbol
Timm10bprovided by MGI
Official Full Name
translocase of inner mitochondrial membrane 10Bprovided by MGI
Primary source
MGI:MGI:1315196
See related
Ensembl:ENSMUSG00000089847 Ensembl:ENSMUSG00000110234 AllianceGenome:MGI:1315196
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Fxc1; Tim9b; Tim10b
Summary
Predicted to enable metal ion binding activity. Predicted to be involved in protein transport. Located in mitochondrion. Is expressed in several structures, including brain; brown fat; exocrine gland; genitourinary system; and thymus. Orthologous to human TIMM10B (translocase of inner mitochondrial membrane 10B). [provided by Alliance of Genome Resources, Dec 2024]
Expression
Ubiquitous expression in adrenal adult (RPKM 28.9), duodenum adult (RPKM 21.6) and 28 other tissues See more
Orthologs
human all
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Genomic context

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See Timm10b in Genome Data Viewer
Location:
7 E3; 7 55.93 cM
Exon count:
8
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 7 NC_000073.7 (105289652..105304955)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 7 NC_000073.6 (105640445..105655748)

Chromosome 7 - NC_000073.7Genomic Context describing neighboring genes Neighboring gene tripartite motif-containing 3 Neighboring gene STARR-positive B cell enhancer ABC_E9700 Neighboring gene ARF interacting protein 2 Neighboring gene predicted gene, 22504 Neighboring gene dynein heavy chain domain 1 Neighboring gene mitochondrial ribosomal protein S36, pseudogene 2 Neighboring gene ribosomal RNA processing 8 Neighboring gene integrin linked kinase

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Cloning of a novel cDNA expressed during the early stages of fracture healing. Hadjiargyrou M, et al. Biochem Biophys Res Commun, 1998 Aug 28. PMID 9731230
  2. The human family of Deafness/Dystonia peptide (DDP) related mitochondrial import proteins. Jin H, et al. Genomics, 1999 Nov 1. PMID 10552927
  3. The mitochondrial TIM22 preprotein translocase is highly conserved throughout the eukaryotic kingdom. Bauer MF, et al. FEBS Lett, 1999 Dec 24. PMID 10611480
  4. Prediction of the coding sequences of mouse homologues of FLJ genes: the complete nucleotide sequences of 110 mouse FLJ-homologous cDnas identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries. Okazaki N, et al. DNA Res, 2004 Apr 30. PMID 15449545
  5. Integrated analysis of protein composition, tissue diversity, and gene regulation in mouse mitochondria. Mootha VK, et al. Cell, 2003 Nov 26. PMID 14651853

See all (21) citations in PubMed

GeneRIFs: Gene References Into Functions

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (2) 

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in protein transport IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
part_of TIM22 mitochondrial import inner membrane insertion complex ISO
Inferred from Sequence Orthology
more info
  
part_of TIM22 mitochondrial import inner membrane insertion complex ISS
Inferred from Sequence or Structural Similarity
more info
  
located_in mitochondrial inner membrane ISO
Inferred from Sequence Orthology
more info
  
located_in mitochondrial intermembrane space ISO
Inferred from Sequence Orthology
more info
  
part_of mitochondrial intermembrane space protein transporter complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of mitochondrial intermembrane space protein transporter complex ISO
Inferred from Sequence Orthology
more info
  
located_in mitochondrion HDA PubMed 

General protein information

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Preferred Names
mitochondrial import inner membrane translocase subunit Tim10 B
Names
Fracture Callus 1
fractured callus 1
fractured callus expressed transcript 1
mitochondrial import inner membrane translocase subunit Tim9 B
small zinc finger-like protein

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001360052.1 → NP_001346981.1  mitochondrial import inner membrane translocase subunit Tim10 B isoform a

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) encodes the longest isoform (a).
    Source sequence(s)
    AC125227
    Consensus CDS
    CCDS90303.1
    UniProtKB/TrEMBL
    D3YVK4
    Related
    ENSMUSP00000102398.2, ENSMUST00000106786.8
    Conserved Domains (1) summary
    pfam02953
    Location:9 → 64
    zf-Tim10_DDP; Tim10/DDP family zinc finger

  2. NM_001360053.1 → NP_001346982.1  mitochondrial import inner membrane translocase subunit Tim10 B isoform b

    Status: VALIDATED

    Source sequence(s)
    AC125227, BY707453
    UniProtKB/TrEMBL
    D3YVK5
    Conserved Domains (1) summary
    pfam02953
    Location:9 → 67
    zf-Tim10_DDP; Tim10/DDP family zinc finger

  3. NM_001360054.1 → NP_001346983.1  mitochondrial import inner membrane translocase subunit Tim10 B isoform c

    Status: VALIDATED

    Source sequence(s)
    AC125227, AV583975
    Consensus CDS
    CCDS90304.1
    UniProtKB/TrEMBL
    D3YVK6
    Related
    ENSMUSP00000102396.2, ENSMUST00000106784.2

  4. NM_001360055.1 → NP_001346984.1  mitochondrial import inner membrane translocase subunit Tim10 B isoform d

    Status: VALIDATED

    Description
    Transcript Variant: This variant (4), as well as variants 5 and 6, encodes isoform d.
    Source sequence(s)
    AC125227
    Consensus CDS
    CCDS21657.1
    UniProtKB/Swiss-Prot
    Q545D2, Q9DCB5, Q9WV96
    UniProtKB/TrEMBL
    D3YVK5
    Related
    ENSMUSP00000102392.2, ENSMUST00000106780.2
    Conserved Domains (1) summary
    pfam02953
    Location:9 → 64
    zf-Tim10_DDP; Tim10/DDP family zinc finger

  5. NM_001360056.1 → NP_001346985.1  mitochondrial import inner membrane translocase subunit Tim10 B isoform d

    Status: VALIDATED

    Description
    Transcript Variant: This variant (5), as well as variants 4 and 6, encodes isoform d.
    Source sequence(s)
    AC125227, AK010994
    Consensus CDS
    CCDS21657.1
    UniProtKB/Swiss-Prot
    Q545D2, Q9DCB5, Q9WV96
    UniProtKB/TrEMBL
    D3YVK5
    Related
    ENSMUSP00000057061.4, ENSMUST00000058333.10
    Conserved Domains (1) summary
    pfam02953
    Location:9 → 64
    zf-Tim10_DDP; Tim10/DDP family zinc finger

  6. NM_001360058.1 → NP_001346987.1  mitochondrial import inner membrane translocase subunit Tim10 B isoform e

    Status: VALIDATED

    Source sequence(s)
    AC125227, CK622744
    Consensus CDS
    CCDS90302.1
    UniProtKB/TrEMBL
    A0A1B0GSU2, D3YVK5
    Related
    ENSMUSP00000148071.2, ENSMUST00000210350.2
    Conserved Domains (1) summary
    pfam02953
    Location:9 → 64
    zf-Tim10_DDP; Tim10/DDP family zinc finger

  7. NM_001360059.1 → NP_001346988.1  mitochondrial import inner membrane translocase subunit Tim10 B isoform f

    Status: VALIDATED

    Source sequence(s)
    AC125227
    UniProtKB/TrEMBL
    D3YVK5
    Conserved Domains (1) summary
    pfam02953
    Location:9 → 64
    zf-Tim10_DDP; Tim10/DDP family zinc finger

  8. NM_001360060.1 → NP_001346989.1  mitochondrial import inner membrane translocase subunit Tim10 B isoform g

    Status: VALIDATED

    Source sequence(s)
    AC125227, AK003421
    Conserved Domains (1) summary
    pfam02953
    Location:1 → 44
    zf-Tim10_DDP; Tim10/DDP family zinc finger

  9. NM_001360061.1 → NP_001346990.1  mitochondrial import inner membrane translocase subunit Tim10 B isoform h

    Status: VALIDATED

    Source sequence(s)
    AC125227
    Consensus CDS
    CCDS90305.1
    UniProtKB/TrEMBL
    A0A1B0GRJ5, D6RG99
    Related
    ENSMUSP00000147720.2, ENSMUST00000209588.2

  10. NM_019502.3 → NP_062375.1  mitochondrial import inner membrane translocase subunit Tim10 B isoform d

    See identical proteins and their annotated locations for NP_062375.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (6), as well as variants 4 and 5, encodes isoform d.
    Source sequence(s)
    AC125227
    Consensus CDS
    CCDS21657.1
    UniProtKB/Swiss-Prot
    Q545D2, Q9DCB5, Q9WV96
    UniProtKB/TrEMBL
    D3YVK5
    Related
    ENSMUSP00000102395.2, ENSMUST00000106783.8
    Conserved Domains (1) summary
    pfam02953
    Location:9 → 64
    zf-Tim10_DDP; Tim10/DDP family zinc finger

RNA

  1. NR_153392.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC125227

  2. NR_153393.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC125227, BY233702

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000073.7 Reference GRCm39 C57BL/6J

    Range
    105289652..105304955
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9WV96.1 GenPept UniProtKB/Swiss-Prot:Q9WV96

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