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Dtx1 deltex 1, E3 ubiquitin ligase [ Mus musculus (house mouse) ]

Gene ID: 14357, updated on 9-Dec-2024

Summary

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Official Symbol
Dtx1provided by MGI
Official Full Name
deltex 1, E3 ubiquitin ligaseprovided by MGI
Primary source
MGI:MGI:1352744
See related
Ensembl:ENSMUSG00000029603 AllianceGenome:MGI:1352744
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Fxit1; mKIAA4160
Summary
Predicted to enable Notch binding activity; ubiquitin protein ligase activity; and ubiquitin protein ligase binding activity. Acts upstream of or within several processes, including Notch signaling pathway; cellular response to leukemia inhibitory factor; and negative regulation of T cell differentiation. Predicted to be located in cytosol and nuclear body. Predicted to be active in nucleoplasm. Is expressed in several structures, including alimentary system; cardiovascular system; central nervous system; genitourinary system; and sensory organ. Orthologous to human DTX1 (deltex E3 ubiquitin ligase 1). [provided by Alliance of Genome Resources, Dec 2024]
Expression
Biased expression in spleen adult (RPKM 82.7), CNS E18 (RPKM 30.0) and 14 other tissues See more
Orthologs
human all
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Genomic context

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See Dtx1 in Genome Data Viewer
Location:
5 F; 5 60.64 cM
Exon count:
12
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 5 NC_000071.7 (120818268..120850879, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 5 NC_000071.6 (120680203..120711867, complement)

Chromosome 5 - NC_000071.7Genomic Context describing neighboring genes Neighboring gene DEAD box helicase 54 Neighboring gene cilia and flagella associated protein 73 Neighboring gene STARR-positive B cell enhancer ABC_E4782 Neighboring gene RAS protein activator like 1 (GAP1 like) Neighboring gene STARR-positive B cell enhancer ABC_E11300 Neighboring gene CapStarr-seq enhancer MGSCv37_chr5:121135771-121135981 Neighboring gene STARR-positive B cell enhancer ABC_E8075 Neighboring gene STARR-positive B cell enhancer ABC_E6371 Neighboring gene STARR-seq mESC enhancer starr_14247 Neighboring gene STARR-seq mESC enhancer starr_14249 Neighboring gene 2'-5' oligoadenylate synthetase 2 Neighboring gene 2'-5' oligoadenylate synthetase 3 Neighboring gene CapStarr-seq enhancer MGSCv37_chr5:121225553-121225736 Neighboring gene CapStarr-seq enhancer MGSCv37_chr5:121225792-121225979

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. A novel cDNA transcript expressed in fractionated X-irradiation-induced murine thymomas. Pampeno CL, et al. Cell Growth Differ, 1996 Aug. PMID 8853908
  2. Genomic analysis and localization of murine Deltex, a modulator of notch activity, to mouse chromosome 5 and its human homolog to chromosome 12. Pampeno CL, et al. DNA Cell Biol, 2001 Mar. PMID 11313017
  3. miR-210-3p Impairs Pancreatic β-Cell Function by Targeting Dtx1 in Gestational Diabetes Mellitus. Cao X, et al. J Environ Pathol Toxicol Oncol, 2022. PMID 36374959
  4. Notch1 confers thymocytes a resistance to GC-induced apoptosis through Deltex1 by blocking the recruitment of p300 to the SRG3 promoter. Jang J, et al. Cell Death Differ, 2006 Sep. PMID 16341126
  5. Deltex1 antagonizes HIF-1α and sustains the stability of regulatory T cells in vivo. Hsiao HW, et al. Nat Commun, 2015 Feb 19. PMID 25695215, Free PMC Article

See all (45) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. miR-210-3p Impairs Pancreatic beta-Cell Function by Targeting Dtx1 in Gestational Diabetes Mellitus.
    Title: miR-210-3p Impairs Pancreatic β-Cell Function by Targeting Dtx1 in Gestational Diabetes Mellitus.
  2. exerts one level of control on regulatory T-cell stability by sustaining the expression of Foxp3 protein
    Title: Deltex1 antagonizes HIF-1α and sustains the stability of regulatory T cells in vivo.
  3. DTX1, similar to Cbl-b and Itch, participates in T cell anergy-induced PKC-theta degradation. there is a coupling of DTX1 to Cbl-b in T cell anergy.
    Title: Deltex1 promotes protein kinase Cθ degradation and sustains Casitas B-lineage lymphoma expression.
  4. Data show that Deltex1 ablation enabled Id1-expressing progenitors to differentiate to the DN3 (CD44(-) CD25(+)) stage, which was accompanied by enhanced Notch1 expression in T-cell progenitors.
    Title: Id1 attenuates Notch signaling and impairs T-cell commitment by elevating Deltex1 expression.
  5. deficiency of DTX1 augmented T cell activation, conferred resistance to anergy induction, enhanced autoantibody generation, and increased inflammation
    Title: Deltex1 is a target of the transcription factor NFAT that promotes T cell anergy.
  6. Deltex can act as a negative regulator of Notch signals in T cells but that endogenous levels of Deltex1 and Deltex2 are not important for regulating Notch signals during thymocyte development[Deltex1]
    Title: T cells develop normally in the absence of both Deltex1 and Deltex2.
  7. Deltex selectively suppresses T-cell activation through degradation of a key signaling molecule, MEKK1.
    Title: Deltex regulates T-cell activation by targeted degradation of active MEKK1.
  8. NB-3/Notch1 pathway promotes neural progenitor cell differentiation into
    Title: NB-3/Notch1 pathway via Deltex1 promotes neural progenitor cell differentiation into oligodendrocytes.
  9. Deltex-1 ubiquitin ligase activity is dispensable for mouse development and immune function.
    Title: Normal immune system development in mice lacking the Deltex-1 RING finger domain.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (3) 
  • Targeted (4)  1 citation

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • KIAA4160

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables Notch binding IEA
Inferred from Electronic Annotation
more info
  
enables Notch binding ISO
Inferred from Sequence Orthology
more info
  
enables SH3 domain binding IEA
Inferred from Electronic Annotation
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables transferase activity IEA
Inferred from Electronic Annotation
more info
  
enables ubiquitin protein ligase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables ubiquitin protein ligase binding IEA
Inferred from Electronic Annotation
more info
  
enables ubiquitin protein ligase binding ISO
Inferred from Sequence Orthology
more info
  
enables zinc ion binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in Notch signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within Notch signaling pathway IDA
Inferred from Direct Assay
more info
 PubMed 
acts_upstream_of_or_within Notch signaling pathway IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of T cell differentiation IDA
Inferred from Direct Assay
more info
 PubMed 
acts_upstream_of_or_within cellular response to leukemia inhibitory factor IEP
Inferred from Expression Pattern
more info
 PubMed 
acts_upstream_of_or_within glial cell differentiation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within negative regulation of T cell differentiation IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in negative regulation of neuron differentiation IEA
Inferred from Electronic Annotation
more info
  
involved_in negative regulation of neuron differentiation ISO
Inferred from Sequence Orthology
more info
  
involved_in protein ubiquitination IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in protein ubiquitination IEA
Inferred from Electronic Annotation
more info
  
involved_in regulation of Notch signaling pathway IEA
Inferred from Electronic Annotation
more info
  
involved_in regulation of Notch signaling pathway ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
located_in cytosol ISO
Inferred from Sequence Orthology
more info
  
located_in cytosol TAS
Traceable Author Statement
more info
  
located_in nuclear body IEA
Inferred from Electronic Annotation
more info
  
located_in nuclear body ISO
Inferred from Sequence Orthology
more info
  
is_active_in nucleoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
  
located_in nucleus ISS
Inferred from Sequence or Structural Similarity
more info
 PubMed 

General protein information

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Preferred Names
E3 ubiquitin-protein ligase DTX1
Names
FXI-T1
RING-type E3 ubiquitin transferase DTX1
deltex 1 homolog
deltex1
fractionated x-irradiation induced transcript 1
mDTX1
protein deltex-1
NP_001404401.1
NP_001404402.1
NP_001404403.1
NP_032078.2
XP_011246483.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001417472.1 → NP_001404401.1  E3 ubiquitin-protein ligase DTX1 isoform a

    Status: VALIDATED

    Source sequence(s)
    AC115937, AC125183
    UniProtKB/TrEMBL
    Q5DTK6

  2. NM_001417473.1 → NP_001404402.1  E3 ubiquitin-protein ligase DTX1 isoform b

    Status: VALIDATED

    Source sequence(s)
    AC115937, AC125183
    UniProtKB/Swiss-Prot
    Q3TER5, Q61010, Q8C2H2, Q9ER09
    UniProtKB/TrEMBL
    Q5DTK6

  3. NM_001417474.1 → NP_001404403.1  E3 ubiquitin-protein ligase DTX1 isoform b

    Status: VALIDATED

    Source sequence(s)
    AC125183
    UniProtKB/Swiss-Prot
    Q3TER5, Q61010, Q8C2H2, Q9ER09
    UniProtKB/TrEMBL
    Q5DTK6

  4. NM_008052.4 → NP_032078.2  E3 ubiquitin-protein ligase DTX1 isoform b

    See identical proteins and their annotated locations for NP_032078.2

    Status: VALIDATED

    Source sequence(s)
    AC115937, AC125183
    Consensus CDS
    CCDS19624.1
    UniProtKB/Swiss-Prot
    Q3TER5, Q61010, Q8C2H2, Q9ER09
    UniProtKB/TrEMBL
    Q5DTK6
    Related
    ENSMUSP00000031607.7, ENSMUST00000031607.7
    Conserved Domains (3) summary
    smart00678
    Location:26 → 102
    WWE; Domain in Deltex and TRIP12 homologues. Possibly involved in regulation of ubiquitin-mediated proteolysis
    cd16671
    Location:415 → 483
    RING-H2_DTX1_4; RING finger, H2 subclass, found in E3 ubiquitin-protein ligase deltex1 (DTX1), deltex4 (DTX4), and similar proteins
    pfam18102
    Location:486 → 620
    DTC; Deltex C-terminal domain

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000071.7 Reference GRCm39 C57BL/6J

    Range
    120818268..120850879 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011248181.4 → XP_011246483.1  E3 ubiquitin-protein ligase DTX1 isoform X1

    See identical proteins and their annotated locations for XP_011246483.1

    UniProtKB/TrEMBL
    Q5DTK6
    Conserved Domains (3) summary
    smart00678
    Location:26 → 102
    WWE; Domain in Deltex and TRIP12 homologues. Possibly involved in regulation of ubiquitin-mediated proteolysis
    cd16671
    Location:415 → 487
    RING-H2_DTX1_4; RING finger, H2 subclass, found in E3 ubiquitin-protein ligase deltex1 (DTX1), deltex4 (DTX4), and similar proteins
    pfam18102
    Location:490 → 624
    DTC; Deltex C-terminal domain
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q61010.2 GenPept UniProtKB/Swiss-Prot:Q61010

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