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Galnt1 polypeptide N-acetylgalactosaminyltransferase 1 [ Mus musculus (house mouse) ]

Gene ID: 14423, updated on 12-May-2024

Summary

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Official Symbol
Galnt1provided by MGI
Official Full Name
polypeptide N-acetylgalactosaminyltransferase 1provided by MGI
Primary source
MGI:MGI:894693
See related
Ensembl:ENSMUSG00000000420 AllianceGenome:MGI:894693
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Summary
Enables polypeptide N-acetylgalactosaminyltransferase activity. Acts upstream of or within protein O-linked glycosylation. Predicted to be located in perinuclear region of cytoplasm. Predicted to be active in Golgi apparatus. Is expressed in several structures, including alimentary system; brain; cranium; respiratory system; and sensory organ. Used to study heart valve disease. Orthologous to human GALNT1 (polypeptide N-acetylgalactosaminyltransferase 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in liver E14 (RPKM 19.5), placenta adult (RPKM 18.4) and 28 other tissues See more
Orthologs
human all
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Genomic context

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See Galnt1 in Genome Data Viewer
Location:
18 A2; 18 12.9 cM
Exon count:
14
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 18 NC_000084.7 (24338401..24419873)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 18 NC_000084.6 (24205321..24286816)

Chromosome 18 - NC_000084.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 41677 Neighboring gene STARR-seq mESC enhancer starr_44057 Neighboring gene INO80 complex subunit C Neighboring gene PRP19/PSO4 pre-mRNA processing factor 19 homolog pseudogene Neighboring gene predicted gene, 38565 Neighboring gene STARR-seq mESC enhancer starr_44062 Neighboring gene predicted gene, 38410

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Severe impairment of leukocyte recruitment in ppGalNAcT-1-deficient mice. Block H, et al. J Immunol, 2012 Jun 1. PMID 22544932
  2. Structure-function analysis of the UDP-N-acetyl-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase. Essential residues lie in a predicted active site cleft resembling a lactose repressor fold. Hagen FK, et al. J Biol Chem, 1999 Mar 5. PMID 10037781
  3. Isoform-specific regulation of osteogenic factors by polypeptide N-Acetylgalactosaminyltransferases 1 and 4. Tang J, et al. Biochem Biophys Res Commun, 2017 Jan 22. PMID 27965094
  4. Control of mucin-type O-glycosylation: a classification of the polypeptide GalNAc-transferase gene family. Bennett EP, et al. Glycobiology, 2012 Jun. PMID 22183981, Free PMC Article
  5. Emerging paradigms for the initiation of mucin-type protein O-glycosylation by the polypeptide GalNAc transferase family of glycosyltransferases. Gerken TA, et al. J Biol Chem, 2011 Apr 22. PMID 21349845, Free PMC Article

See all (45) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. the ppGalNAc-T4 was highly expressed in MC3T3-E1 cells during osteogenesis for the first time; ppGalNAc-T1 and -T4 affected the expression of different osteogenic factors, suggesting distinct roles ppGalNAc-T isoforms play in regulating osteogenesis in vitro
    Title: Isoform-specific regulation of osteogenic factors by polypeptide N-Acetylgalactosaminyltransferases 1 and 4.
  2. Study show that in Galnt1 null mouse, there is compromised cardiac function that mimics human congenital heart disease suggesting that Galnt1 expression is required for normal heart valve development.
    Title: Galnt1 is required for normal heart valve development and cardiac function.
  3. The GALNT1 is the glycosyltransferase enzyme family covering a single known glycosidic linkage.
    Title: Control of mucin-type O-glycosylation: a classification of the polypeptide GalNAc-transferase gene family.
  4. Polypeptide GalNAcT-1 plays a predominant role in leukocyte recruitment in vivo by attaching functionally relevant O-linked glycans to L-selectin ligands.
    Title: Severe impairment of leukocyte recruitment in ppGalNAcT-1-deficient mice.
  5. each ppGalNAc T isoform may be uniquely sensitive to peptide sequence and overall charge, which together dictates the substrate sites that will be glycosylated
    Title: Emerging paradigms for the initiation of mucin-type protein O-glycosylation by the polypeptide GalNAc transferase family of glycosyltransferases.
  6. Growth factor stimulation regulates O-glycosylation initiation in a Src-dependent fashion by GalNac-T redistribution from golgi to the endoplasmic reticulum.
    Title: Regulation of O-glycosylation through Golgi-to-ER relocation of initiation enzymes.
  7. ppGalNAcT-1 to be indispensable for O-glycosylation at specific sites of the bone glycoproteins OPN and BSP.
    Title: Isoform-specific O-glycosylation of osteopontin and bone sialoprotein by polypeptide N-acetylgalactosaminyltransferase-1.
  8. These findings reveal that the initiation of protein O glycosylation by ppGalNAcT-1 provides a distinctive repertoire of advantageous functions that support vascular responses and humoral immunity.
    Title: Initiation of protein O glycosylation by the polypeptide GalNAcT-1 in vascular biology and humoral immunity.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (2) 
  • Gene trapped (1) 
  • Targeted (2)  1 citation

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables carbohydrate binding IEA
Inferred from Electronic Annotation
more info
  
enables glycosyltransferase activity IEA
Inferred from Electronic Annotation
more info
  
enables manganese ion binding ISO
Inferred from Sequence Orthology
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables polypeptide N-acetylgalactosaminyltransferase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables polypeptide N-acetylgalactosaminyltransferase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables polypeptide N-acetylgalactosaminyltransferase activity ISO
Inferred from Sequence Orthology
more info
  
enables transferase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in protein O-linked glycosylation IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within protein O-linked glycosylation IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in protein O-linked glycosylation ISO
Inferred from Sequence Orthology
more info
  
involved_in protein O-linked glycosylation via serine ISO
Inferred from Sequence Orthology
more info
  
involved_in protein O-linked glycosylation via threonine ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
is_active_in Golgi apparatus IBA
Inferred from Biological aspect of Ancestor
more info
  
colocalizes_with Golgi apparatus ISO
Inferred from Sequence Orthology
more info
  
located_in extracellular region IEA
Inferred from Electronic Annotation
more info
  
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
located_in perinuclear region of cytoplasm ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
polypeptide N-acetylgalactosaminyltransferase 1
Names
UDP-GalNAc:polypeptide N-acetylgalactosaminyltransferase 1
UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase 1
galNAc-T1
polypeptide GalNAc transferase 1
pp-GaNTase 1
ppGaNTase-T1
protein-UDP acetylgalactosaminyltransferase 1
NP_001153876.1
NP_001348129.1
NP_038842.3

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001160404.1 → NP_001153876.1  polypeptide N-acetylgalactosaminyltransferase 1

    See identical proteins and their annotated locations for NP_001153876.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 3. Variants 1, 2 and 3 encode the same protein.
    Source sequence(s)
    AK085878, AK148550, BC090962, BY711053, CX123572
    Consensus CDS
    CCDS29100.1
    UniProtKB/Swiss-Prot
    O08912, Q5BKS3, Q7TND1
    Related
    ENSMUSP00000132142.2, ENSMUST00000170243.8
    Conserved Domains (2) summary
    cd02510
    Location:119 → 419
    pp-GalNAc-T; pp-GalNAc-T initiates the formation of mucin-type O-linked glycans
    pfam00652
    Location:432 → 548
    Ricin_B_lectin; Ricin-type beta-trefoil lectin domain

  2. NM_001361200.1 → NP_001348129.1  polypeptide N-acetylgalactosaminyltransferase 1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) represents the longest transcript. Variants 1, 2 and 3 encode the same protein.
    Source sequence(s)
    AC134856
    Consensus CDS
    CCDS29100.1
    UniProtKB/Swiss-Prot
    O08912, Q5BKS3, Q7TND1
    Conserved Domains (2) summary
    cd02510
    Location:119 → 419
    pp-GalNAc-T; pp-GalNAc-T initiates the formation of mucin-type O-linked glycans
    pfam00652
    Location:432 → 548
    Ricin_B_lectin; Ricin-type beta-trefoil lectin domain

  3. NM_013814.3 → NP_038842.3  polypeptide N-acetylgalactosaminyltransferase 1

    See identical proteins and their annotated locations for NP_038842.3

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) differs in the 5' UTR compared to variant 3. Variants 1, 2 and 3 encode the same protein.
    Source sequence(s)
    AK085878, BC056215, BC090962, BY142456, CX123572
    Consensus CDS
    CCDS29100.1
    UniProtKB/Swiss-Prot
    O08912, Q5BKS3, Q7TND1
    Related
    ENSMUSP00000000430.8, ENSMUST00000000430.14
    Conserved Domains (2) summary
    cd02510
    Location:119 → 419
    pp-GalNAc-T; pp-GalNAc-T initiates the formation of mucin-type O-linked glycans
    pfam00652
    Location:432 → 548
    Ricin_B_lectin; Ricin-type beta-trefoil lectin domain

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000084.7 Reference GRCm39 C57BL/6J

    Range
    24338401..24419873
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
O08912.1 GenPept UniProtKB/Swiss-Prot:O08912

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