Kat2a K(lysine) acetyltransferase 2A [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Kat2aprovided by MGI
Official Full Name: K(lysine) acetyltransferase 2Aprovided by MGI
Primary source: MGI:MGI:1343101
See related: Ensembl:ENSMUSG00000020918 AllianceGenome:MGI:1343101
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Gcn5; Gcn5l2; mmGCN5; 1110051E14Rik
Summary: Enables DNA-binding transcription factor binding activity; chromatin binding activity; and histone acetyltransferase activity. Involved in several processes, including long-term memory; positive regulation of macromolecule biosynthetic process; and regulation of regulatory T cell differentiation. Acts upstream of or within several processes, including brain development; chordate embryonic development; and positive regulation of gluconeogenesis. Located in mitotic spindle and nucleus. Part of ATAC complex and SAGA complex. Is expressed in several structures, including alimentary system; central nervous system; early conceptus; genitourinary system; and hemolymphoid system gland. Orthologous to human KAT2A (lysine acetyltransferase 2A). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Ubiquitous expression in adrenal adult (RPKM 33.5), ovary adult (RPKM 29.4) and 28 other tissues See more
Orthologs: human all
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Genomic context

Location:: 11 D; 11 63.53 cM

Exon count:: 18

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	11	NC_000077.7 (100595572..100603293, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	11	NC_000077.6 (100704746..100712485, complement)

Chromosome 11 - NC_000077.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Deletion of Ulk1 inhibits neointima formation by enhancing KAT2A/GCN5-mediated acetylation of TUBA/alpha-tubulin in vivo.
Title: Deletion of Ulk1 inhibits neointima formation by enhancing KAT2A/GCN5-mediated acetylation of TUBA/α-tubulin in vivo.
GCN5-mediated regulation of pathological cardiac hypertrophy via activation of the TAK1-JNK/p38 signaling pathway.
Title: GCN5-mediated regulation of pathological cardiac hypertrophy via activation of the TAK1-JNK/p38 signaling pathway.
Acetyltransferases GCN5 and PCAF Are Required for B Lymphocyte Maturation in Mice.
Title: Acetyltransferases GCN5 and PCAF Are Required for B Lymphocyte Maturation in Mice.
GCN5 maintains muscle integrity by acetylating YY1 to promote dystrophin expression.
Title: GCN5 maintains muscle integrity by acetylating YY1 to promote dystrophin expression.
Loss of Kat2a enhances transcriptional noise and depletes acute myeloid leukemia stem-like cells.
Title: Loss of Kat2a enhances transcriptional noise and depletes acute myeloid leukemia stem-like cells.
Transcriptional Activation of MYC-Induced Genes by GCN5 Promotes B-cell Lymphomagenesis.
Title: Transcriptional Activation of MYC-Induced Genes by GCN5 Promotes B-cell Lymphomagenesis.
Crystal structure of GCN5 PCAF N-terminal domain reveals atypical ubiquitin ligase structure.
Title: Crystal structure of GCN5 PCAF N-terminal domain reveals atypical ubiquitin ligase structure.
GCN5 acetylation is required for craniofacial chondrocyte maturation.
Title: GCN5 acetylation is required for craniofacial chondrocyte maturation.
Islet-1 synergizes with Gcn5 to promote MSC differentiation into cardiomyocytes.
Title: Islet-1 synergizes with Gcn5 to promote MSC differentiation into cardiomyocytes.
that Gcn5-mediated histone acetylation promotes chromatin accessibility and nucleosome eviction in spermiogenesis
Title: Gcn5-Mediated Histone Acetylation Governs Nucleosome Dynamics in Spermiogenesis.

Submit: New GeneRIF Correction See all GeneRIFs (42)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (3)
Targeted (9) 1 citation

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

RH126579 (e-PCR)
- UniSTS:209702

AW212720 (e-PCR)
- UniSTS:180313

Gcn5l2 (e-PCR), detects polymorphism
- UniSTS:257227

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables DNA-binding transcription factor binding	IPI Inferred from Physical Interaction more info	PubMed
enables DNA-binding transcription factor binding	ISO Inferred from Sequence Orthology more info
enables N-acetyltransferase activity	IDA Inferred from Direct Assay more info	PubMed
enables acetyltransferase activity	IDA Inferred from Direct Assay more info	PubMed
enables chromatin binding	IDA Inferred from Direct Assay more info	PubMed
enables chromatin binding	ISO Inferred from Sequence Orthology more info
enables histone H2AK5 acetyltransferase activity	IEA Inferred from Electronic Annotation more info
enables histone H2AK9 acetyltransferase activity	IEA Inferred from Electronic Annotation more info
enables histone H2BK12 acetyltransferase activity	IEA Inferred from Electronic Annotation more info
enables histone H2BK5 acetyltransferase activity	IEA Inferred from Electronic Annotation more info
enables histone H3 acetyltransferase activity	IBA Inferred from Biological aspect of Ancestor more info
enables histone H3 acetyltransferase activity	IDA Inferred from Direct Assay more info	PubMed
enables histone H3 acetyltransferase activity	ISO Inferred from Sequence Orthology more info
enables histone H3K122 acetyltransferase activity	IEA Inferred from Electronic Annotation more info
enables histone H3K14 acetyltransferase activity	IEA Inferred from Electronic Annotation more info
enables histone H3K18 acetyltransferase activity	IDA Inferred from Direct Assay more info	PubMed
enables histone H3K23 acetyltransferase activity	IEA Inferred from Electronic Annotation more info
enables histone H3K27 acetyltransferase activity	IEA Inferred from Electronic Annotation more info
enables histone H3K36 acetyltransferase activity	IEA Inferred from Electronic Annotation more info
enables histone H3K4 acetyltransferase activity	IEA Inferred from Electronic Annotation more info
enables histone H3K56 acetyltransferase activity	IEA Inferred from Electronic Annotation more info
enables histone H3K9 acetyltransferase activity	IDA Inferred from Direct Assay more info	PubMed
enables histone H3K9 acetyltransferase activity	ISO Inferred from Sequence Orthology more info
enables histone H4K12 acetyltransferase activity	IDA Inferred from Direct Assay more info	PubMed
enables histone H4K16 acetyltransferase activity	IEA Inferred from Electronic Annotation more info
enables histone H4K5 acetyltransferase activity	IEA Inferred from Electronic Annotation more info
enables histone H4K8 acetyltransferase activity	IEA Inferred from Electronic Annotation more info
enables histone acetyltransferase activity	IDA Inferred from Direct Assay more info	PubMed
enables histone acetyltransferase activity	ISO Inferred from Sequence Orthology more info
enables histone deacetylase binding	IEA Inferred from Electronic Annotation more info
enables histone deacetylase binding	ISO Inferred from Sequence Orthology more info
enables histone glutaryltransferase activity	ISO Inferred from Sequence Orthology more info
enables histone glutaryltransferase activity	ISS Inferred from Sequence or Structural Similarity more info
enables histone succinyltransferase activity	ISO Inferred from Sequence Orthology more info
enables histone succinyltransferase activity	ISS Inferred from Sequence or Structural Similarity more info
enables peptide-lysine-N-acetyltransferase activity	ISO Inferred from Sequence Orthology more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein phosphatase binding	IEA Inferred from Electronic Annotation more info
enables protein phosphatase binding	ISO Inferred from Sequence Orthology more info
enables transcription coactivator activity	ISO Inferred from Sequence Orthology more info
enables transcription coactivator activity	ISS Inferred from Sequence or Structural Similarity more info

Process	Evidence Code	Pubs
involved_in cellular response to nerve growth factor stimulus	IEA Inferred from Electronic Annotation more info
involved_in cellular response to tumor necrosis factor	IEA Inferred from Electronic Annotation more info
involved_in chromatin remodeling	IBA Inferred from Biological aspect of Ancestor more info
involved_in chromatin remodeling	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within fibroblast proliferation	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of gluconeogenesis	IGI Inferred from Genetic Interaction more info	PubMed
involved_in heart development	ISS Inferred from Sequence or Structural Similarity more info
acts_upstream_of_or_within in utero embryonic development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in internal peptidyl-lysine acetylation	ISO Inferred from Sequence Orthology more info
involved_in intracellular distribution of mitochondria	IEA Inferred from Electronic Annotation more info
involved_in intracellular distribution of mitochondria	ISO Inferred from Sequence Orthology more info
involved_in limb development	ISS Inferred from Sequence or Structural Similarity more info
involved_in long-term memory	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within metencephalon development	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within midbrain development	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within multicellular organism growth	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of centriole replication	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of centriole replication	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of gluconeogenesis	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of gluconeogenesis	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of transcription by RNA polymerase II	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of transcription by RNA polymerase II	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within nervous system development	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within neural tube closure	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in peptidyl-lysine glutarylation	ISO Inferred from Sequence Orthology more info
involved_in peptidyl-lysine glutarylation	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of DNA-templated transcription	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of DNA-templated transcription	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of DNA-templated transcription	NAS Non-traceable Author Statement more info	PubMed
involved_in positive regulation of cardiac muscle cell differentiation	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of cardiac muscle cell differentiation	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of cell projection organization	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of cell projection organization	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of cytokine production	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within positive regulation of gluconeogenesis	IGI Inferred from Genetic Interaction more info	PubMed
involved_in positive regulation of transcription by RNA polymerase II	IBA Inferred from Biological aspect of Ancestor more info
involved_in positive regulation of transcription by RNA polymerase II	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of transcription by RNA polymerase II	ISO Inferred from Sequence Orthology more info
involved_in protein modification process	ISO Inferred from Sequence Orthology more info
involved_in regulation of DNA repair	NAS Non-traceable Author Statement more info	PubMed
involved_in regulation of DNA-templated transcription	ISO Inferred from Sequence Orthology more info
involved_in regulation of RNA splicing	NAS Non-traceable Author Statement more info	PubMed
involved_in regulation of T cell activation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of bone development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of cartilage development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of cell cycle	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of cell cycle	ISO Inferred from Sequence Orthology more info
involved_in regulation of cell division	IDA Inferred from Direct Assay more info	PubMed
involved_in regulation of cell division	ISO Inferred from Sequence Orthology more info
involved_in regulation of embryonic development	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within regulation of protein stability	ISO Inferred from Sequence Orthology more info
involved_in regulation of regulatory T cell differentiation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of stem cell population maintenance	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of synaptic plasticity	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of transcription by RNA polymerase II	ISO Inferred from Sequence Orthology more info
involved_in regulation of tubulin deacetylation	ISO Inferred from Sequence Orthology more info
involved_in response to nutrient levels	IEA Inferred from Electronic Annotation more info
involved_in response to organic cyclic compound	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within somitogenesis	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within somitogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within telencephalon development	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
part_of ATAC complex	IBA Inferred from Biological aspect of Ancestor more info
part_of ATAC complex	IDA Inferred from Direct Assay more info	PubMed
part_of ATAC complex	ISO Inferred from Sequence Orthology more info
part_of SAGA complex	IDA Inferred from Direct Assay more info	PubMed
part_of SAGA complex	ISO Inferred from Sequence Orthology more info
part_of SAGA complex	NAS Non-traceable Author Statement more info	PubMed
located_in centrosome	ISO Inferred from Sequence Orthology more info
located_in centrosome	ISS Inferred from Sequence or Structural Similarity more info
located_in chromatin	ISO Inferred from Sequence Orthology more info
part_of histone acetyltransferase complex	IDA Inferred from Direct Assay more info	PubMed
part_of histone acetyltransferase complex	ISO Inferred from Sequence Orthology more info
located_in mitotic spindle	IDA Inferred from Direct Assay more info	PubMed
located_in mitotic spindle	NAS Non-traceable Author Statement more info	PubMed
located_in nucleoplasm	TAS Traceable Author Statement more info
located_in nucleus	IDA Inferred from Direct Assay more info	PubMed
located_in nucleus	ISO Inferred from Sequence Orthology more info
part_of oxoglutarate dehydrogenase complex	ISO Inferred from Sequence Orthology more info
part_of oxoglutarate dehydrogenase complex	ISS Inferred from Sequence or Structural Similarity more info
part_of transcription factor TFTC complex	ISO Inferred from Sequence Orthology more info
part_of transcription factor TFTC complex	NAS Non-traceable Author Statement more info	PubMed

General protein information

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Preferred Names: histone acetyltransferase KAT2A

Names: GCN5 general control of amino acid synthesis-like 2; PCAF-B/GCN5; general control of amino acid synthesis 5-like 2; general control of amino acid synthesis protein 5-like 2; general control of amino acid synthesis, yeast homolog-like 2; general control of amino acid synthesis-like 2; histone acetyltransferase GCN5; histone glutaryltransferase KAT2A; histone succinyltransferase KAT2A; lysine acetyltransferase 2A

NP_001033099.1

EC 2.3.1.48

NP_064388.2

EC 2.3.1.48

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001038010.2 → NP_001033099.1 histone acetyltransferase KAT2A isoform b

See identical proteins and their annotated locations for NP_001033099.1

Status: VALIDATED

Description

Transcript Variant: This variant (2) uses an alternate in-frame splice site in the coding region, compared to variant 1. This results in a shorter protein (isoform b), compared to isoform a.

Source sequence(s)

AK155842, AL591469, AV014576

Consensus CDS

CCDS25432.1

UniProtKB/TrEMBL

Q3UD69, Q6P3Z8

Related

ENSMUSP00000006973.6, ENSMUST00000006973.12

Conserved Domains (4) summary

cd05509
Location:724 → 823

Bromo_gcn5_like; Bromodomain; Gcn5_like subfamily. Gcn5p is a histone acetyltransferase (HAT) which mediates acetylation of histones at lysine residues; such acetylation is generally correlated with the activation of transcription. Bromodomains are 110 amino acid long ...

COG5076
Location:484 → 824

COG5076; Transcription factor involved in chromatin remodeling, contains bromodomain [Chromatin structure and dynamics / Transcription]

pfam00583
Location:547 → 619

Acetyltransf_1; Acetyltransferase (GNAT) family

pfam06466
Location:81 → 330

PCAF_N; PCAF (P300/CBP-associated factor) N-terminal domain
NM_020004.5 → NP_064388.2 histone acetyltransferase KAT2A isoform a

See identical proteins and their annotated locations for NP_064388.2

Status: VALIDATED

Description

Transcript Variant: This variant (1) encodes the longer isoform (a).

Source sequence(s)

AK155842, AK158079, AL591469, AV014576

Consensus CDS

CCDS25433.1

UniProtKB/Swiss-Prot

Q3TZ59, Q9JHD2

UniProtKB/TrEMBL

Q3UD69

Related

ENSMUSP00000099407.4, ENSMUST00000103118.4

Conserved Domains (3) summary

cd05509
Location:725 → 824

Bromo_gcn5_like; Bromodomain; Gcn5_like subfamily. Gcn5p is a histone acetyltransferase (HAT) which mediates acetylation of histones at lysine residues; such acetylation is generally correlated with the activation of transcription. Bromodomains are 110 amino acid long ...

COG5076
Location:485 → 825

COG5076; Transcription factor involved in chromatin remodeling, contains bromodomain [Chromatin structure and dynamics / Transcription]

pfam06466
Location:84 → 330

PCAF_N; PCAF (P300/CBP-associated factor) N-terminal domain

RNA

NR_166132.1 RNA Sequence

Status: VALIDATED

Source sequence(s)

AL591469

Related

ENSMUST00000153526.8
NR_166133.1 RNA Sequence

Status: VALIDATED

Source sequence(s)

AL591469