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Gdf1 growth differentiation factor 1 [ Mus musculus (house mouse) ]

Gene ID: 14559, updated on 9-Dec-2024

Summary

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Official Symbol
Gdf1provided by MGI
Official Full Name
growth differentiation factor 1provided by MGI
Primary source
MGI:MGI:95683
See related
Ensembl:ENSMUSG00000087408 Ensembl:ENSMUSG00000109523 AllianceGenome:MGI:95683
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Gdf-1
Summary
This gene encodes a secreted ligand of the TGF-beta (transforming growth factor-beta) superfamily of proteins. Ligands of this family bind various TGF-beta receptors leading to recruitment and activation of SMAD family transcription factors that regulate gene expression. The encoded preproprotein is proteolytically processed to generate each subunit of the disulfide-linked homodimer. This protein is involved in the establishment of left-right asymmetry in early embryogenesis and in neural development in later embryogenesis. This protein is translated from a monocistronic mRNA early in development, and from a bicistronic mRNA in later stages that also encodes ceramide synthase 1. [provided by RefSeq, Jul 2016]
Expression
Biased expression in frontal lobe adult (RPKM 27.2), cortex adult (RPKM 24.4) and 11 other tissues See more
Orthologs
human all
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Genomic context

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See Gdf1 in Genome Data Viewer
Location:
8 B3.3; 8 34.15 cM
Exon count:
8
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 8 NC_000074.7 (70768425..70784242)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 8 NC_000074.6 (70315775..70331592)

Chromosome 8 - NC_000074.7Genomic Context describing neighboring genes Neighboring gene homer scaffolding protein 3 Neighboring gene STARR-positive B cell enhancer ABC_E8240 Neighboring gene DEAD box helicase 49 Neighboring gene coatomer protein complex, subunit epsilon Neighboring gene ceramide synthase 1 Neighboring gene UPF1 RNA helicase and ATPase Neighboring gene STARR-seq mESC enhancer starr_21770 Neighboring gene predicted gene, 51533 Neighboring gene cartilage oligomeric matrix protein Neighboring gene CREB regulated transcription coactivator 1

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. GDF1 ameliorates cognitive impairment induced by hearing loss. Pan L, et al. Nat Aging, 2024 Apr. PMID 38491289
  2. Epigenetic silencing of GDF1 disrupts SMAD signaling to reinforce gastric cancer development. Yang W, et al. Oncogene, 2016 Apr 21. PMID 26212015
  3. Mesendoderm induction and reversal of left-right pattern by mouse Gdf1, a Vg1-related gene. Wall NA, et al. Dev Biol, 2000 Nov 15. PMID 11071769
  4. Generation and characterization of a Gdf1 conditional null allele. Bengtsson H, et al. Genesis, 2008 Jul. PMID 18615710
  5. Identification of a novel member (GDF-1) of the transforming growth factor-beta superfamily. Lee SJ. Mol Endocrinol, 1990 Jul. PMID 1704486

See all (52) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. GDF1 ameliorates cognitive impairment induced by hearing loss.
    Title: GDF1 ameliorates cognitive impairment induced by hearing loss.
  2. Epigenetic silencing of GDF1 abrogates the growth-inhibitory SMAD signaling and renders proliferation advantage to gastric epithelial cells during carcinogenesis
    Title: Epigenetic silencing of GDF1 disrupts SMAD signaling to reinforce gastric cancer development.
  3. GDF1 in the heart is a novel mediator that protects against the development of post-infarction cardiac remodelling via negative regulation of the MEK-ERK1/2 and Smad signalling pathways.
    Title: Cardioprotective role of growth/differentiation factor 1 in post-infarction left ventricular remodelling and dysfunction.
  4. This implies that Gdf1 potentiates Nodal activity by stabilizing a low molecular weight fraction that is susceptible to neutralization by soluble Acvr2.
    Title: Nodal·Gdf1 heterodimers with bound prodomains enable serum-independent nodal signaling and endoderm differentiation.
  5. Data indicate that the expression of growth/differentiation factor 1 (GDF1) is up-regulated in human dilated cardiomyopathy (DCM)hearts and murine hypertrophic hearts.
    Title: Growth/differentiation factor 1 alleviates pressure overload-induced cardiac hypertrophy and dysfunction.
  6. Results suggest that GDF1 and GDF3 together represent the functional mammalian homologs of Vg1.
    Title: Distinct and cooperative roles of mammalian Vg1 homologs GDF1 and GDF3 during early embryonic development.
  7. GDF1 regulates the activity and signaling range of Nodal through direct interaction
    Title: Long-range action of Nodal requires interaction with GDF1.
  8. GDF-1 and Nodal converge on ALK4 in the anterior primitive streak to control the formation of organizing centers that are necessary for normal forebrain and branchial arch development
    Title: Synergistic interaction between Gdf1 and Nodal during anterior axis development.
  9. Recombinant mouse GDF1 signaling in zebrafish depends on EGF-CFC proteins, but not on Nodal signals. GDF1 binds to and signal through Activin receptors only in the presence of EGF-CFC proteins.
    Title: EGF-CFC proteins are essential coreceptors for the TGF-beta signals Vg1 and GDF1.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (1) 
  • Targeted (3)  1 citation

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables cytokine activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables cytokine activity IEA
Inferred from Electronic Annotation
more info
  
enables growth factor activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within endoderm development IGI
Inferred from Genetic Interaction
more info
 PubMed 
acts_upstream_of_or_within in utero embryonic development IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within mesoderm development IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in negative regulation of cardiac muscle hypertrophy ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within signal transduction IGI
Inferred from Genetic Interaction
more info
 PubMed 
acts_upstream_of_or_within signal transduction IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
located_in extracellular region TAS
Traceable Author Statement
more info
  
is_active_in extracellular space IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in extracellular space IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
embryonic growth/differentiation factor 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001163282.2 → NP_001156754.1  embryonic growth/differentiation factor 1 precursor

    See identical proteins and their annotated locations for NP_001156754.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the longer, bicistronic transcript that is expressed after embryonic stage E9.
    Source sequence(s)
    AC158553, AK162823, BB183489, BC079555, BC132318
    Consensus CDS
    CCDS52571.1
    UniProtKB/Swiss-Prot
    P20863, Q6AXH1
    UniProtKB/TrEMBL
    Q3TRG1
    Related
    ENSMUSP00000128325.3, ENSMUST00000165819.9
    Conserved Domains (2) summary
    smart00204
    Location:251 → 357
    TGFB; Transforming growth factor-beta (TGF-beta) family
    pfam00688
    Location:36 → 141
    TGFb_propeptide; TGF-beta propeptide

  2. NM_008107.4 → NP_032133.2  embryonic growth/differentiation factor 1 precursor

    See identical proteins and their annotated locations for NP_032133.2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) represents use of an alternate promoter and 5' UTR without a bicistronic structure, compared to variant 1. This variant is expressed at embryonic stage E8.5 to E9.5.
    Source sequence(s)
    BC056973, BC079555
    Consensus CDS
    CCDS52571.1
    UniProtKB/Swiss-Prot
    P20863, Q6AXH1
    UniProtKB/TrEMBL
    Q3TRG1
    Related
    ENSMUSP00000146749.2, ENSMUST00000207684.2
    Conserved Domains (2) summary
    smart00204
    Location:251 → 357
    TGFB; Transforming growth factor-beta (TGF-beta) family
    pfam00688
    Location:36 → 141
    TGFb_propeptide; TGF-beta propeptide

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000074.7 Reference GRCm39 C57BL/6J

    Range
    70768425..70784242
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P20863.2 GenPept UniProtKB/Swiss-Prot:P20863

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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