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Glra4 glycine receptor, alpha 4 subunit [ Mus musculus (house mouse) ]

Gene ID: 14657, updated on 9-Dec-2024

Summary

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Official Symbol
Glra4provided by MGI
Official Full Name
glycine receptor, alpha 4 subunitprovided by MGI
Primary source
MGI:MGI:95750
See related
Ensembl:ENSMUSG00000018595 AllianceGenome:MGI:95750
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Summary
Enables extracellularly glycine-gated chloride channel activity. Involved in chloride transmembrane transport and response to amino acid. Located in plasma membrane. Is active in glycinergic synapse and postsynaptic specialization membrane. Is expressed in brain. Orthologous to human GLRA4 (glycine receptor alpha 4 (pseudogene)). [provided by Alliance of Genome Resources, Dec 2024]
Expression
Low expression observed in reference dataset See more
Orthologs
human all
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Genomic context

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See Glra4 in Genome Data Viewer
Location:
X F1; X 59.1 cM
Exon count:
11
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) X NC_000086.8 (135655107..135680935, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) X NC_000086.7 (136754515..136780141, complement)

Chromosome X - NC_000086.8Genomic Context describing neighboring genes Neighboring gene predicted gene, 39536 Neighboring gene transcription elongation factor A (SII)-like 1 Neighboring gene STARR-seq mESC enhancer starr_47978 Neighboring gene STARR-positive B cell enhancer ABC_E3262 Neighboring gene mortality factor 4 like 2 Neighboring gene STARR-positive B cell enhancer ABC_E11056 Neighboring gene cDNA sequence BC065397 Neighboring gene predicted gene, 54085 Neighboring gene STARR-seq mESC enhancer starr_47979 Neighboring gene proteolipid protein (myelin) 1 Neighboring gene RAB9B, member RAS oncogene family

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Glycine receptors containing the alpha4 subunit in the embryonic sympathetic nervous system, spinal cord and male genital ridge. Harvey RJ, et al. Eur J Neurosci, 2000 Mar. PMID 10762330
  2. Diversity of glycine receptors in the mouse retina: localization of the alpha4 subunit. Heinze L, et al. J Comp Neurol, 2007 Feb 1. PMID 17154252
  3. Native glycine receptor subtypes and their physiological roles. Lynch JW. Neuropharmacology, 2009 Jan. PMID 18721822
  4. Glycinergic input of widefield, displaced amacrine cells of the mouse retina. Majumdar S, et al. J Physiol, 2009 Aug 1. PMID 19528249, Free PMC Article
  5. Developmental regulation of glycine receptors at efferent synapses of the murine cochlea. Buerbank S, et al. Histochem Cell Biol, 2011 Oct. PMID 21850450

See all (22) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. The distinct developmental regulation of GlyRalpha4 in the murine cochlea advocates a contribution of these chloride channels to efferent olivocochlear innervation.
    Title: Developmental regulation of glycine receptors at efferent synapses of the murine cochlea.
  2. Glycine receptors (GlyRs) of group II cells are dominated by the alpha2 subunit; GlyRs of ON-starburst amacrine cells appear to be dominated by the alpha4 subunit.
    Title: Glycinergic input of widefield, displaced amacrine cells of the mouse retina.
  3. The alpha4 subunit was localized in the inner plexiform layer (IPL) in brightly fluorescent puncta, which represent postsynaptically clustered glycine receptors.
    Title: Diversity of glycine receptors in the mouse retina: localization of the alpha4 subunit.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (2) 

General gene information

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Markers

Homology

Clone Names

  • MGC130223, MGC130237

Gene Ontology Provided by MGI

Function Evidence Code Pubs
contributes_to chloride channel activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables excitatory extracellular ligand-gated monoatomic ion channel activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables extracellularly glycine-gated chloride channel activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables glycine binding IEA
Inferred from Electronic Annotation
more info
  
enables transmembrane signaling receptor activity IEA
Inferred from Electronic Annotation
more info
  
enables transmitter-gated monoatomic ion channel activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in chloride transmembrane transport IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in chloride transmembrane transport IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in excitatory postsynaptic potential IEA
Inferred from Electronic Annotation
more info
  
involved_in response to amino acid IDA
Inferred from Direct Assay
more info
 PubMed 
Component Evidence Code Pubs
part_of chloride channel complex IEA
Inferred from Electronic Annotation
more info
  
located_in dendrite IEA
Inferred from Electronic Annotation
more info
  
is_active_in glycinergic synapse IDA
Inferred from Direct Assay
more info
 PubMed 
located_in perikaryon IEA
Inferred from Electronic Annotation
more info
  
located_in plasma membrane IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in postsynaptic specialization membrane IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
glycine receptor subunit alpha-4

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001425633.1 → NP_001412562.1  glycine receptor subunit alpha-4 isoform 2 precursor

    Status: VALIDATED

    Source sequence(s)
    AL671887

  2. NM_001425634.1 → NP_001412563.1  glycine receptor subunit alpha-4 isoform 3 precursor

    Status: VALIDATED

    Source sequence(s)
    AL671887

  3. NM_001425635.1 → NP_001412564.1  glycine receptor subunit alpha-4 isoform 4 precursor

    Status: VALIDATED

    Source sequence(s)
    AL671887

  4. NM_001425636.1 → NP_001412565.1  glycine receptor subunit alpha-4 isoform 5

    Status: VALIDATED

    Source sequence(s)
    AL671887
    UniProtKB/TrEMBL
    Q2TB05

  5. NM_010297.3 → NP_034427.2  glycine receptor subunit alpha-4 isoform 1 precursor

    See identical proteins and their annotated locations for NP_034427.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) encodes the longest isoform (1).
    Source sequence(s)
    AL671887
    Consensus CDS
    CCDS53195.1
    UniProtKB/Swiss-Prot
    A2AEA9, Q45V76, Q61603, Q8VHF3
    UniProtKB/TrEMBL
    Q2TB05
    Related
    ENSMUSP00000018739.5, ENSMUST00000018739.5
    Conserved Domains (1) summary
    TIGR00860
    Location:9 → 444
    LIC; Cation transporter family protein

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000086.8 Reference GRCm39 C57BL/6J

    Range
    135655107..135680935 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q61603.3 GenPept UniProtKB/Swiss-Prot:Q61603

Gene LinkOut

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