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Cmklr1 chemerin chemokine-like receptor 1 [ Mus musculus (house mouse) ]

Gene ID: 14747, updated on 9-Dec-2024

Summary

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Official Symbol
Cmklr1provided by MGI
Official Full Name
chemerin chemokine-like receptor 1provided by MGI
Primary source
MGI:MGI:109603
See related
Ensembl:ENSMUSG00000042190 AllianceGenome:MGI:109603
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
DEZ; Gpcr27; ChemR23; mcmklr1
Summary
Predicted to enable adipokinetic hormone binding activity; adipokinetic hormone receptor activity; and transmembrane signaling receptor activity. Involved in negative regulation of interleukin-12 production; positive regulation of cold-induced thermogenesis; and positive regulation of fat cell differentiation. Predicted to be active in plasma membrane. Is expressed in several structures, including brain; embryo mesenchyme; jaw; lung; and uterus. Orthologous to human CMKLR1 (chemerin chemokine-like receptor 1). [provided by Alliance of Genome Resources, Dec 2024]
Expression
Biased expression in lung adult (RPKM 58.5), subcutaneous fat pad adult (RPKM 38.4) and 12 other tissues See more
Orthologs
human all
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Genomic context

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See Cmklr1 in Genome Data Viewer
Location:
5 F; 5 55.55 cM
Exon count:
10
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 5 NC_000071.7 (113750415..113792971, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 5 NC_000071.6 (113612355..113650475, complement)

Chromosome 5 - NC_000071.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 30812 Neighboring gene WSC domain containing 2 Neighboring gene STARR-seq mESC enhancer starr_14042 Neighboring gene predicted gene, 52822 Neighboring gene STARR-seq mESC enhancer starr_14044 Neighboring gene STARR-seq mESC enhancer starr_14048 Neighboring gene STARR-seq mESC enhancer starr_14049 Neighboring gene predicted gene 15736 Neighboring gene predicted gene, 52823 Neighboring gene RIKEN cDNA 1700069L16 gene Neighboring gene predicted gene, 46919 Neighboring gene STARR-positive B cell enhancer ABC_E2171 Neighboring gene FIC domain containing

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Disruption of the chemokine-like receptor-1 (CMKLR1) gene is associated with reduced adiposity and glucose intolerance. Ernst MC, et al. Endocrinology, 2012 Feb. PMID 22186410, Free PMC Article
  2. Chemokine-Like Receptor 1 Is a Novel Wnt Target Gene that Regulates Mesenchymal Stem Cell Differentiation. Muruganandan S, et al. Stem Cells, 2017 Mar. PMID 27733019
  3. CMKLR1 deficiency maintains ovarian steroid production in mice treated chronically with dihydrotestosterone. Tang M, et al. Sci Rep, 2016 Feb 19. PMID 26893072, Free PMC Article
  4. Contrasting effects of cold acclimation versus obesogenic diets on chemerin gene expression in brown and brite adipose tissues. Hansen IR, et al. Biochim Biophys Acta, 2014 Dec. PMID 25224322
  5. Inconsequential role for chemerin-like receptor 1 in the manifestation of ozone-induced lung pathophysiology in male mice. Johnston RA, et al. Physiol Rep, 2024 Apr. PMID 38631890, Free PMC Article

See all (86) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. The chemerin-CMKLR1 axis in keratinocytes impairs innate host defense against cutaneous Staphylococcus aureus infection.
    Title: The chemerin-CMKLR1 axis in keratinocytes impairs innate host defense against cutaneous Staphylococcus aureus infection.
  2. ChemR23 signaling ameliorates brain injury via inhibiting NLRP3 inflammasome-mediated neuronal pyroptosis in ischemic stroke.
    Title: ChemR23 signaling ameliorates brain injury via inhibiting NLRP3 inflammasome-mediated neuronal pyroptosis in ischemic stroke.
  3. Resolvin E1/ChemR23 Protects Against Hypertension and Vascular Remodeling in Angiotensin II-Induced Hypertensive Mice.
    Title: Resolvin E1/ChemR23 Protects Against Hypertension and Vascular Remodeling in Angiotensin II-Induced Hypertensive Mice.
  4. miR-22-3p ameliorates the symptoms of premature ovarian failure in mice by inhibiting CMKLR1 expression.
    Title: miR-22-3p ameliorates the symptoms of premature ovarian failure in mice by inhibiting CMKLR1 expression.
  5. n-3 Polyunsaturated Fatty Acids Modulate LPS-Induced ARDS and the Lung-Brain Axis of Communication in Wild-Type versus Fat-1 Mice Genetically Modified for Leukotriene B4 Receptor 1 or Chemerin Receptor 23 Knockout.
    Title: n-3 Polyunsaturated Fatty Acids Modulate LPS-Induced ARDS and the Lung-Brain Axis of Communication in Wild-Type versus Fat-1 Mice Genetically Modified for Leukotriene B4 Receptor 1 or Chemerin Receptor 23 Knockout.
  6. The chemerin/CMKLR1 axis regulates intestinal graft-versus-host disease.
    Title: The chemerin/CMKLR1 axis regulates intestinal graft-versus-host disease.
  7. Chemokine-like receptor 1 deficiency impedes macrophage phenotypic transformation and cardiac repair after myocardial infarction.
    Title: Chemokine-like receptor 1 deficiency impedes macrophage phenotypic transformation and cardiac repair after myocardial infarction.
  8. ChemR23 signaling ameliorates cognitive impairments in diabetic mice via dampening oxidative stress and NLRP3 inflammasome activation.
    Title: ChemR23 signaling ameliorates cognitive impairments in diabetic mice via dampening oxidative stress and NLRP3 inflammasome activation.
  9. The Chemerin/CMKLR1 Axis Is Involved in the Recruitment of Microglia to Abeta Deposition through p38 MAPK Pathway.
    Title: The Chemerin/CMKLR1 Axis Is Involved in the Recruitment of Microglia to Aβ Deposition through p38 MAPK Pathway.
  10. Epithelial chemerin-CMKLR1 signaling restricts microbiota-driven colonic neutrophilia and tumorigenesis by up-regulating lactoperoxidase.
    Title: Epithelial chemerin-CMKLR1 signaling restricts microbiota-driven colonic neutrophilia and tumorigenesis by up-regulating lactoperoxidase.
Submit: New GeneRIF Correction See all GeneRIFs (49)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Pathways from PubChem

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General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables G protein-coupled receptor activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables G protein-coupled receptor activity IEA
Inferred from Electronic Annotation
more info
  
enables adipokinetic hormone binding ISO
Inferred from Sequence Orthology
more info
  
enables adipokinetic hormone binding ISS
Inferred from Sequence or Structural Similarity
more info
  
enables adipokinetic hormone receptor activity ISO
Inferred from Sequence Orthology
more info
  
enables adipokinetic hormone receptor activity ISS
Inferred from Sequence or Structural Similarity
more info
  
enables complement receptor activity IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in G protein-coupled receptor signaling pathway ISO
Inferred from Sequence Orthology
more info
  
involved_in G protein-coupled receptor signaling pathway ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in chemotaxis IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in chemotaxis IEA
Inferred from Electronic Annotation
more info
  
involved_in chemotaxis ISO
Inferred from Sequence Orthology
more info
  
involved_in complement receptor mediated signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in inflammatory response IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in negative regulation of NF-kappaB transcription factor activity ISO
Inferred from Sequence Orthology
more info
  
involved_in negative regulation of NF-kappaB transcription factor activity ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in negative regulation of interleukin-12 production IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in phospholipase C-activating G protein-coupled receptor signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in positive regulation of cold-induced thermogenesis IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in positive regulation of cytosolic calcium ion concentration IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in positive regulation of fat cell differentiation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in positive regulation of macrophage chemotaxis IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in positive regulation of macrophage chemotaxis IEA
Inferred from Electronic Annotation
more info
  
involved_in positive regulation of macrophage chemotaxis ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of calcium-mediated signaling IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in regulation of calcium-mediated signaling IEA
Inferred from Electronic Annotation
more info
  
involved_in regulation of calcium-mediated signaling ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in plasma membrane ISO
Inferred from Sequence Orthology
more info
  
located_in plasma membrane ISS
Inferred from Sequence or Structural Similarity
more info
  

General protein information

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Preferred Names
chemerin-like receptor 1
Names
G-protein coupled receptor 27
G-protein coupled receptor DEZ
chemerin receptor
chemokine receptor-like 1
chemokine-like receptor 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001359060.1 → NP_001345989.1  chemerin-like receptor 1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript. Variants 1 and 2 both encode the same protein.
    Source sequence(s)
    AC241893, CJ072893
    Consensus CDS
    CCDS19551.1
    UniProtKB/Swiss-Prot
    P97468
    UniProtKB/TrEMBL
    E9Q8N2, Q497D3
    Conserved Domains (1) summary
    cd15116
    Location:39 → 325
    7tmA_CMKLR1; chemokine-like receptor 1, member of the class A family of seven-transmembrane G protein-coupled receptors

  2. NM_008153.3 → NP_032179.1  chemerin-like receptor 1

    See identical proteins and their annotated locations for NP_032179.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Variants 1 and 2 both encode the same protein.
    Source sequence(s)
    AC241893, BY347978
    Consensus CDS
    CCDS19551.1
    UniProtKB/Swiss-Prot
    P97468
    UniProtKB/TrEMBL
    E9Q8N2, Q497D3
    Related
    ENSMUSP00000036316.7, ENSMUST00000047936.13
    Conserved Domains (1) summary
    cd15116
    Location:39 → 325
    7tmA_CMKLR1; chemokine-like receptor 1, member of the class A family of seven-transmembrane G protein-coupled receptors

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000071.7 Reference GRCm39 C57BL/6J

    Range
    113750415..113792971 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_036164795.1 → XP_036020688.1  chemerin-like receptor 1 isoform X1

    UniProtKB/Swiss-Prot
    P97468
    UniProtKB/TrEMBL
    E9Q8N2, Q497D3
    Conserved Domains (1) summary
    cd15116
    Location:39 → 325
    7tmA_CMKLR1; chemokine-like receptor 1, member of the class A family of seven-transmembrane G protein-coupled receptors

  2. XM_006530164.5 → XP_006530227.1  chemerin-like receptor 1 isoform X1

    See identical proteins and their annotated locations for XP_006530227.1

    UniProtKB/Swiss-Prot
    P97468
    UniProtKB/TrEMBL
    E9Q8N2, Q497D3
    Conserved Domains (1) summary
    cd15116
    Location:39 → 325
    7tmA_CMKLR1; chemokine-like receptor 1, member of the class A family of seven-transmembrane G protein-coupled receptors

  3. XM_006530166.3 → XP_006530229.1  chemerin-like receptor 1 isoform X1

    See identical proteins and their annotated locations for XP_006530229.1

    UniProtKB/Swiss-Prot
    P97468
    UniProtKB/TrEMBL
    E9Q8N2, Q497D3
    Related
    ENSMUSP00000121765.2, ENSMUST00000132065.8
    Conserved Domains (1) summary
    cd15116
    Location:39 → 325
    7tmA_CMKLR1; chemokine-like receptor 1, member of the class A family of seven-transmembrane G protein-coupled receptors

  4. XM_006530165.4 → XP_006530228.1  chemerin-like receptor 1 isoform X1

    See identical proteins and their annotated locations for XP_006530228.1

    UniProtKB/Swiss-Prot
    P97468
    UniProtKB/TrEMBL
    E9Q8N2, Q497D3
    Conserved Domains (1) summary
    cd15116
    Location:39 → 325
    7tmA_CMKLR1; chemokine-like receptor 1, member of the class A family of seven-transmembrane G protein-coupled receptors
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P97468.1 GenPept UniProtKB/Swiss-Prot:P97468

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