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vif vif protein [ Simian immunodeficiency virus ]

Gene ID: 1490005, updated on 15-Aug-2018

Summary

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Gene symbol
vif
Gene description
vif protein
Locus tag
SIVgp2
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Simian immunodeficiency virus (isolate: 677, nat-host: Cercopithecus aethiops (African green monkey))
Lineage
Viruses; Retro-transcribing viruses; Retroviridae; Orthoretrovirinae; Lentivirus; Primate lentivirus group
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Genomic context

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Location:
clone: gri-1
Sequence:
NC_001549.1 (5214..5873)

NC_001549.1Genomic Context describing neighboring genes Neighboring gene Gag-Pol;gag protein Neighboring gene vpx protein Neighboring gene Neighboring gene Neighboring gene envelope protein Neighboring gene nef protein

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_001549.1

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Disruption of the putative splice acceptor site for SIV(mac239)Vif reveals tight control of SIV splicing and impaired replication in Vif non-permissive cells. Victoria JG, et al. Virology, 2005 Aug 1. PMID 15950999
  2. Degradation of the cancer genomic DNA deaminase APOBEC3B by SIV Vif. Land AM, et al. Oncotarget, 2015 Nov 24. PMID 26544511, Free PMC Article
  3. Vif counteracts a cyclophilin A-imposed inhibition of simian immunodeficiency viruses in human cells. Takeuchi H, et al. J Virol, 2007 Aug. PMID 17522232, Free PMC Article
  4. Conserved and non-conserved features of HIV-1 and SIVagm Vif mediated suppression of APOBEC3 cytidine deaminases. Zhang W, et al. Cell Microbiol, 2008 Aug. PMID 18419775, Free PMC Article
  5. Comparative thermodynamic analysis of zinc binding to the His/Cys motif in virion infectivity factor. Ghimire-Rijal S, et al. Inorg Chem, 2014 May 5. PMID 24735396

See all (9) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Data indicate that SIVmac239 Vif protein efficiently degrades human DNA cytosine deaminase APOBEC3B protein (huA3B).
    Title: Degradation of the cancer genomic DNA deaminase APOBEC3B by SIV Vif.
  2. CBF-beta is critical for the formation of the Vif-ElonginB/ElonginC-Cul5 core E3 ubiquitin ligase complex.
    Title: Evolutionarily conserved requirement for core binding factor beta in the assembly of the human immunodeficiency virus/simian immunodeficiency virus Vif-cullin 5-RING E3 ubiquitin ligase.
  3. The arginine at position 14 of the SIV Vif is a critical residue for virus restriction by rhA3D, rhA3G and rhA3H.
    Title: Analysis of the N-terminal positively charged residues of the simian immunodeficiency virus Vif reveals a critical amino acid required for the antagonism of rhesus APOBEC3D, G, and H.
  4. simian immunodeficiency virus (SIV) Vif binds to and requires CBF-beta to degrade rhesus macaque APOBEC3G
    Title: Vif hijacks CBF-β to degrade APOBEC3G and promote HIV-1 infection.
  5. Cul5-E3 ubiquitin ligase appears to be a common pathway hijacked by HIV-1 and SIV Vif to defeat APOBEC3 proteins.
    Title: Conserved and non-conserved features of HIV-1 and SIVagm Vif mediated suppression of APOBEC3 cytidine deaminases.
  6. Results describe a novel vif-sensitive antiviral activity of human cyclophilin A that may limit zoonotic transmission of SIV and the first demonstration of CypA encapsidation into a virus other than human immunodeficiency virus type 1.
    Title: Vif counteracts a cyclophilin A-imposed inhibition of simian immunodeficiency viruses in human cells.
  7. Efficient splicing of SIV vif mRNA is tightly controlled and requires the SA1 site.
    Title: Disruption of the putative splice acceptor site for SIV(mac239)Vif reveals tight control of SIV splicing and impaired replication in Vif non-permissive cells.
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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

General protein information

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Preferred Names
vif protein

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001549.1 Reference assembly

    Range
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NP_054370.1 vif protein [Simian immunodeficiency virus]

    See identical proteins and their annotated locations for NP_054370.1

    Status: PROVISIONAL

    UniProtKB/Swiss-Prot
    Q02841
    Conserved Domains (1) summary
    pfam00559
    Location:4 → 154
    Vif; Retroviral Vif (Viral infectivity) protein
Nucleotide Protein
Heading Accession and Version

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