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gag-pol Gag-Pol;gag protein [ Simian immunodeficiency virus ]

Gene ID: 1490009, updated on 29-Jul-2022

Summary

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Gene symbol
gag-pol
Gene description
Gag-Pol;gag protein
Locus tag
SIVgp1
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Simian immunodeficiency virus (isolate: 677, nat-host: Cercopithecus aethiops (African green monkey))
Lineage
Viruses; Retro-transcribing viruses; Retroviridae; Orthoretrovirinae; Lentivirus; Primate lentivirus group
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Genomic context

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Location:
clone: gri-1
Sequence:
NC_001549.1 (897..5314)

NC_001549.1Genomic Context describing neighboring genes Neighboring gene vif protein Neighboring gene vpx protein Neighboring gene Neighboring gene Neighboring gene envelope protein Neighboring gene nef protein

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_001549.1

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. An internal ribosome entry site promotes translation of a novel SIV Pr55(Gag) isoform. Nicholson MG, et al. Virology, 2006 Jun 5. PMID 16494914
  2. Structure of the zinc finger domain encompassing residues 13-51 of the nucleocapsid protein from simian immunodeficiency virus. Morellet N, et al. Biochem J, 2006 Feb 1. PMID 16229684, Free PMC Article
  3. Conserved serines in simian immunodeficiency virus capsid are required for virus budding. Rue SM, et al. Virology, 2005 May 25. PMID 15866069
  4. In vitro binding of simian immunodeficiency virus matrix protein to the cytoplasmic domain of the envelope glycoprotein. Manrique JM, et al. Virology, 2008 May 10. PMID 18255119
  5. Mechanism of host cell MAPK/ERK-2 incorporation into lentivirus particles: characterization of the interaction between MAPK/ERK-2 and proline-rich-domain containing capsid region of structural protein Gag. Gupta P, et al. J Mol Biol, 2011 Jul 22. PMID 21762808

See all (8) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. The interaction of MAPK/ERK-2 with Gag polyprotein results in its incorporation into virus particles and may be essential for retroviral replication.
    Title: Mechanism of host cell MAPK/ERK-2 incorporation into lentivirus particles: characterization of the interaction between MAPK/ERK-2 and proline-rich-domain containing capsid region of structural protein Gag.
  2. results strongly support the notion that the association between the SIV matrix domain of Gag and Env cytoplasmic domain plays a central role in the process of SIV Env incorporation into Gag-made particles
    Title: In vitro binding of simian immunodeficiency virus matrix protein to the cytoplasmic domain of the envelope glycoprotein.
  3. identifid an N-terminally truncated SIV Pr55(Gag) isoform expressed from the SIV gag gene SIV p43; translation of SIV p43 is driven by an IRES located entirely within the coding region of gag mRNA
    Title: An internal ribosome entry site promotes translation of a novel SIV Pr55(Gag) isoform.
  4. results indicate that certain residues in the capsid N terminus are crucial for early budding events
    Title: Conserved serines in simian immunodeficiency virus capsid are required for virus budding.
  5. NMR structure of SIV NCp8 compared with that of HIV NCp7
    Title: Structure of the zinc finger domain encompassing residues 13-51 of the nucleocapsid protein from simian immunodeficiency virus.
Submit: New GeneRIF Correction

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Miscellaneous features

  • Loc: 897-5314 pol protein

General protein information

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Preferred Names
Gag-Pol;gag protein

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001549.1 Reference assembly

    Range
    897..5314
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NP_687035.1 Gag-Pol [Simian immunodeficiency virus]

    See identical proteins and their annotated locations for NP_687035.1

    Status: PROVISIONAL

    UniProtKB/Swiss-Prot
    Q02836
    Conserved Domains (13) summary
    smart00343
    Location:391 → 406
    ZnF_C2HC; zinc finger
    pfam00540
    Location:2 → 135
    Gag_p17; gag gene protein p17 (matrix protein)
    pfam00075
    Location:1050 → 1166
    RNase_H; RNase H
    pfam00078
    Location:672 → 843
    RVT_1; Reverse transcriptase (RNA-dependent DNA polymerase)
    pfam00098
    Location:411 → 428
    zf-CCHC; Zinc knuckle
    pfam00552
    Location:1391 → 1437
    IN_DBD_C; Integrase DNA binding domain
    pfam00607
    Location:151 → 366
    Gag_p24; gag gene protein p24 (core nucleocapsid protein)
    pfam00665
    Location:1228 → 1329
    rve; Integrase core domain
    pfam02022
    Location:1177 → 1213
    Integrase_Zn; Integrase Zinc binding domain
    pfam06815
    Location:928 → 1028
    RVT_connect; Reverse transcriptase connection domain
    pfam06817
    Location:852 → 906
    RVT_thumb; Reverse transcriptase thumb domain
    cl02808
    Location:627 → 843
    RT_like; RT_like: Reverse transcriptase (RT, RNA-dependent DNA polymerase)_like family. An RT gene is usually indicative of a mobile element such as a retrotransposon or retrovirus. RTs occur in a variety of mobile elements, including retrotransposons, ...
    cl11403
    Location:512 → 605
    pepsin_retropepsin_like; Cellular and retroviral pepsin-like aspartate proteases

  2. NP_054369.1 gag protein [Simian immunodeficiency virus]

    See identical proteins and their annotated locations for NP_054369.1

    Status: PROVISIONAL

    UniProtKB/Swiss-Prot
    Q02843
    UniProtKB/TrEMBL
    Q6LDM5
    Conserved Domains (3) summary
    pfam00098
    Location:411 → 428
    zf-CCHC; Zinc knuckle
    pfam00540
    Location:2 → 135
    Gag_p17; gag gene protein p17 (matrix protein)
    pfam00607
    Location:151 → 357
    Gag_p24; gag gene protein p24 (core nucleocapsid protein)
Nucleotide Protein
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