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ZNF362 zinc finger protein 362 [ Homo sapiens (human) ]

Gene ID: 149076, updated on 4-Jan-2025

Summary

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Official Symbol
ZNF362provided by HGNC
Official Full Name
zinc finger protein 362provided by HGNC
Primary source
HGNC:HGNC:18079
See related
Ensembl:ENSG00000160094 AllianceGenome:HGNC:18079
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
RN; lin-29
Summary
Predicted to enable DNA-binding transcription factor activity and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Predicted to be involved in regulation of transcription by RNA polymerase II. Predicted to be located in nucleus. [provided by Alliance of Genome Resources, Jan 2025]
Expression
Ubiquitous expression in spleen (RPKM 4.1), kidney (RPKM 3.8) and 25 other tissues See more
Orthologs
mouse all
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Genomic context

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See ZNF362 in Genome Data Viewer
Location:
1p35.1
Exon count:
14
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 1 NC_000001.11 (33127522..33300719)
RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 1 NC_060925.1 (32987140..33162335)
RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 1 NC_000001.10 (33722093..33766320)

Chromosome 1 - NC_000001.11Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC124903969 Neighboring gene uncharacterized LOC105378635 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 615 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:33549697-33550196 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:33557899-33558556 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 706 Neighboring gene antizyme inhibitor 2 Neighboring gene BRD4-independent group 4 enhancer GRCh37_chr1:33592415-33593614 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 616 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:33605527-33606126 Neighboring gene H3K27ac hESC enhancer GRCh37_chr1:33606727-33607326 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:33628780-33629512 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:33629513-33630245 Neighboring gene Neanderthal introgressed variant-containing enhancer experimental_7027 Neighboring gene tripartite motif containing 62 Neighboring gene Neanderthal introgressed variant-containing enhancer experimental_7034 Neighboring gene Neanderthal introgressed variant-containing enhancer experimental_7044 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 617 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 619 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 618 Neighboring gene Neanderthal introgressed variant-containing enhancer experimental_7054 Neighboring gene Neanderthal introgressed variant-containing enhancer experimental_7061 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 620 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:33685009-33685609 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:33685744-33686528 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:33709758-33710342 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 621 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 622 Neighboring gene Sharpr-MPRA regulatory region 4113 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:33729134-33729634 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:33734235-33734736 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:33760897-33761407 Neighboring gene ReSE screen-validated silencer GRCh37_chr1:33764372-33764552 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:33764984-33765933 Neighboring gene MPRA-validated peak168 silencer Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:33795184-33795684 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:33795685-33796185 Neighboring gene alpha 1,3-galactosyltransferase 2 Neighboring gene microRNA 3605 Neighboring gene polyhomeotic homolog 2

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Tissue-specific circular RNA induction during human fetal development
  • Description: 35 human fetal samples from 6 tissues (3 - 7 replicates per tissue) collected between 10 and 20 weeks gestational time were sequenced using Illumina TruSeq Stranded Total RNA
  • BioProject: PRJNA270632
  • Publication: PMID 26076956
  • Analysis date: Mon Apr 2 22:54:59 2018

Bibliography

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Related articles in PubMed

  1. Identification of the SOX2 Interactome by BioID Reveals EP300 as a Mediator of SOX2-dependent Squamous Differentiation and Lung Squamous Cell Carcinoma Growth. Kim BR, et al. Mol Cell Proteomics, 2017 Oct. PMID 28794006, Free PMC Article
  2. USP7 Regulates Cytokinesis through FBXO38 and KIF20B. Georges A, et al. Sci Rep, 2019 Feb 25. PMID 30804394, Free PMC Article
  3. Mutations of the Transcriptional Corepressor ZMYM2 Cause Syndromic Urinary Tract Malformations. Connaughton DM, et al. Am J Hum Genet, 2020 Oct 1. PMID 32891193, Free PMC Article
  4. Proximity-dependent Mapping of the Androgen Receptor Identifies Kruppel-like Factor 4 as a Functional Partner. Vélot L, et al. Mol Cell Proteomics, 2021. PMID 33640491, Free PMC Article
  5. Mapping the Ku Interactome Using Proximity-Dependent Biotin Identification in Human Cells. Abbasi S, et al. J Proteome Res, 2019 Mar 1. PMID 30585729

See all (33) citations in PubMed

GeneRIFs: Gene References Into Functions

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • FLJ25476, MGC138318

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables DNA-binding transcription factor activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
zinc finger protein 362
Names
rotund homolog

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001370212.1 → NP_001357141.1  zinc finger protein 362

    Status: VALIDATED

    Source sequence(s)
    AL513327
    Consensus CDS
    CCDS377.1
    UniProtKB/Swiss-Prot
    Q5T0B9, Q8WYU4
    Related
    ENSP00000362527.5, ENST00000373428.5
    Conserved Domains (5) summary
    COG5189
    Location:307 → 359
    SFP1; Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning]
    PRK14971
    Location:27 → 125
    PRK14971; DNA polymerase III subunit gamma/tau
    sd00017
    Location:257 → 277
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00096
    Location:255 → 277
    zf-C2H2; Zinc finger, C2H2 type
    pfam13465
    Location:269 → 294
    zf-H2C2_2; Zinc-finger double domain

  2. NM_152493.3 → NP_689706.2  zinc finger protein 362

    See identical proteins and their annotated locations for NP_689706.2

    Status: VALIDATED

    Source sequence(s)
    AF318356, AL513327, AW204855, BF743001, BX283663
    Consensus CDS
    CCDS377.1
    UniProtKB/Swiss-Prot
    Q5T0B9, Q8WYU4
    Related
    ENSP00000446335.1, ENST00000539719.6
    Conserved Domains (5) summary
    COG5189
    Location:307 → 359
    SFP1; Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning]
    PRK14971
    Location:27 → 125
    PRK14971; DNA polymerase III subunit gamma/tau
    sd00017
    Location:257 → 277
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00096
    Location:255 → 277
    zf-C2H2; Zinc finger, C2H2 type
    pfam13465
    Location:269 → 294
    zf-H2C2_2; Zinc-finger double domain

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000001.11 Reference GRCh38.p14 Primary Assembly

    Range
    33127522..33300719
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_047447108.1 → XP_047303064.1  zinc finger protein 362 isoform X1

    Conserved Domains (5) summary
    COG5189
    Location:325 → 377
    SFP1; Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning]
    PRK14971
    Location:45 → 143
    PRK14971; DNA polymerase III subunit gamma/tau
    sd00017
    Location:275 → 295
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00096
    Location:273 → 295
    zf-C2H2; Zinc finger, C2H2 type
    pfam13465
    Location:287 → 312
    zf-H2C2_2; Zinc-finger double domain

  2. XM_047447107.1 → XP_047303063.1  zinc finger protein 362 isoform X1

    Conserved Domains (5) summary
    COG5189
    Location:325 → 377
    SFP1; Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning]
    PRK14971
    Location:45 → 143
    PRK14971; DNA polymerase III subunit gamma/tau
    sd00017
    Location:275 → 295
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00096
    Location:273 → 295
    zf-C2H2; Zinc finger, C2H2 type
    pfam13465
    Location:287 → 312
    zf-H2C2_2; Zinc-finger double domain

  3. XM_047447110.1 → XP_047303066.1  zinc finger protein 362 isoform X4

  4. XM_005270507.3 → XP_005270564.1  zinc finger protein 362 isoform X3

    See identical proteins and their annotated locations for XP_005270564.1

    Conserved Domains (5) summary
    COG5189
    Location:294 → 346
    SFP1; Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning]
    PRK14971
    Location:14 → 112
    PRK14971; DNA polymerase III subunit gamma/tau
    sd00017
    Location:244 → 264
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00096
    Location:242 → 264
    zf-C2H2; Zinc finger, C2H2 type
    pfam13465
    Location:256 → 281
    zf-H2C2_2; Zinc-finger double domain

  5. XM_047447109.1 → XP_047303065.1  zinc finger protein 362 isoform X2

    UniProtKB/Swiss-Prot
    Q5T0B9, Q8WYU4

  6. XM_005270508.6 → XP_005270565.1  zinc finger protein 362 isoform X3

    See identical proteins and their annotated locations for XP_005270565.1

    Conserved Domains (5) summary
    COG5189
    Location:294 → 346
    SFP1; Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning]
    PRK14971
    Location:14 → 112
    PRK14971; DNA polymerase III subunit gamma/tau
    sd00017
    Location:244 → 264
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00096
    Location:242 → 264
    zf-C2H2; Zinc finger, C2H2 type
    pfam13465
    Location:256 → 281
    zf-H2C2_2; Zinc-finger double domain

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060925.1 Alternate T2T-CHM13v2.0

    Range
    32987140..33162335
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054334631.1 → XP_054190606.1  zinc finger protein 362 isoform X1

  2. XM_054334630.1 → XP_054190605.1  zinc finger protein 362 isoform X1

  3. XM_054334635.1 → XP_054190610.1  zinc finger protein 362 isoform X4

  4. XM_054334633.1 → XP_054190608.1  zinc finger protein 362 isoform X3

  5. XM_054334632.1 → XP_054190607.1  zinc finger protein 362 isoform X2

    UniProtKB/Swiss-Prot
    Q5T0B9, Q8WYU4

  6. XM_054334634.1 → XP_054190609.1  zinc finger protein 362 isoform X3

Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q5T0B9.1 GenPept UniProtKB/Swiss-Prot:Q5T0B9

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