Gzmb granzyme B [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Gzmbprovided by MGI
Official Full Name: granzyme Bprovided by MGI
Primary source: MGI:MGI:109267
See related: Ensembl:ENSMUSG00000015437 AllianceGenome:MGI:109267
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: GZB; CCP1; Ctla1; Ctla-1; CCP-1/C11
Summary: This gene encodes a member of the granzyme subfamily of proteins, part of the peptidase S1 family of serine proteases. The encoded preproprotein is secreted by natural killer (NK) cells and cytotoxic T lymphocytes (CTLs) and proteolytically processed to generate the active protease, which induces target cell apoptosis. This protein also processes cytokines and degrades extracellular matrix proteins, and these roles are implicated in chronic inflammation and wound healing. Mice lacking a functional copy of this gene exhibit impaired immune cell-mediated cytolysis. [provided by RefSeq, Sep 2016]
Expression: Biased expression in large intestine adult (RPKM 11.7), small intestine adult (RPKM 4.9) and 8 other tissues See more
Orthologs: human all
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Genomic context

Location:: 14 C3; 14 28.19 cM

Exon count:: 5

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	14	NC_000080.7 (56496293..56499791, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	14	NC_000080.6 (56258836..56262334, complement)

Chromosome 14 - NC_000080.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

NK cell-derived extracellular granzyme B drives epithelial ulceration during HSV-2 genital infection.
Title: NK cell-derived extracellular granzyme B drives epithelial ulceration during HSV-2 genital infection.
Inhibitory Effect of Zinc on Colorectal Cancer by Granzyme B Transcriptional Regulation in Cytotoxic T Cells.
Title: Inhibitory Effect of Zinc on Colorectal Cancer by Granzyme B Transcriptional Regulation in Cytotoxic T Cells.
gammadelta Intraepithelial Lymphocytes Facilitate Pathological Epithelial Cell Shedding Via CD103-Mediated Granzyme Release.
Title: γδ Intraepithelial Lymphocytes Facilitate Pathological Epithelial Cell Shedding Via CD103-Mediated Granzyme Release.
Granzyme B prevents aberrant IL-17 production and intestinal pathogenicity in CD4(+) T cells.
Title: Granzyme B prevents aberrant IL-17 production and intestinal pathogenicity in CD4(+) T cells.
Cytotoxic CD8(+) T cells promote granzyme B-dependent adverse post-ischemic cardiac remodeling.
Title: Cytotoxic CD8(+) T cells promote granzyme B-dependent adverse post-ischemic cardiac remodeling.
Maternal diesel particle exposure promotes offspring asthma through NK cell-derived granzyme B.
Title: Maternal diesel particle exposure promotes offspring asthma through NK cell-derived granzyme B.
Granzyme B inhibition reduces disease severity in autoimmune blistering diseases.
Title: Granzyme B inhibition reduces disease severity in autoimmune blistering diseases.
Differential cleavage of viral polypeptides by allotypic variants of granzyme B skews immunity to mouse cytomegalovirus.
Title: Differential cleavage of viral polypeptides by allotypic variants of granzyme B skews immunity to mouse cytomegalovirus.
Granzyme B deficiency promotes osteoblastic differentiation and calcification of vascular smooth muscle cells in hypoxic pulmonary hypertension.
Title: Granzyme B deficiency promotes osteoblastic differentiation and calcification of vascular smooth muscle cells in hypoxic pulmonary hypertension.
Letter: in contact hypersensitivitgy, MHC class I on radioresistent cells mediates granzyme B expression in CD8+ T cells, while MHC class I on radiosensitive cells mediate both IFN-g and granzyme B production.
Title: Requirement of MHC class I on radioresistant cells for granzyme B expression from CD8(+) T cells in murine contact hypersensitivity.

Submit: New GeneRIF Correction See all GeneRIFs (81)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (7) 1 citation
Targeted (5) 1 citation

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

AI553453 (e-PCR)
- UniSTS:180636

Gzmb (e-PCR), detects polymorphism
- UniSTS:143284

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables serine-type endopeptidase activity	IBA Inferred from Biological aspect of Ancestor more info
enables serine-type endopeptidase activity	IDA Inferred from Direct Assay more info	PubMed
enables serine-type endopeptidase activity	ISO Inferred from Sequence Orthology more info
enables serine-type peptidase activity	IDA Inferred from Direct Assay more info	PubMed
enables serine-type peptidase activity	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within T cell mediated cytotoxicity	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in apoptotic process	IEA Inferred from Electronic Annotation more info
involved_in defense response to bacterium	IDA Inferred from Direct Assay more info	PubMed
involved_in granzyme-mediated programmed cell death signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within granzyme-mediated programmed cell death signaling pathway	IDA Inferred from Direct Assay more info	PubMed
involved_in granzyme-mediated programmed cell death signaling pathway	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within granzyme-mediated programmed cell death signaling pathway	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in granzyme-mediated programmed cell death signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in killing of cells of another organism	IEA Inferred from Electronic Annotation more info
involved_in natural killer cell mediated cytotoxicity	ISO Inferred from Sequence Orthology more info
involved_in natural killer cell mediated cytotoxicity	ISS Inferred from Sequence or Structural Similarity more info
involved_in negative regulation of translation	ISO Inferred from Sequence Orthology more info
involved_in protein maturation	IBA Inferred from Biological aspect of Ancestor more info
involved_in protein maturation	IDA Inferred from Direct Assay more info	PubMed
involved_in protein maturation	ISO Inferred from Sequence Orthology more info
involved_in proteolysis involved in protein catabolic process	ISO Inferred from Sequence Orthology more info
involved_in proteolysis involved in protein catabolic process	ISS Inferred from Sequence or Structural Similarity more info
involved_in pyroptotic inflammatory response	ISO Inferred from Sequence Orthology more info
involved_in pyroptotic inflammatory response	ISS Inferred from Sequence or Structural Similarity more info

Component	Evidence Code	Pubs
located_in cytolytic granule	IDA Inferred from Direct Assay more info	PubMed
located_in cytolytic granule	ISO Inferred from Sequence Orthology more info
located_in cytolytic granule	ISS Inferred from Sequence or Structural Similarity more info
is_active_in cytoplasm	IDA Inferred from Direct Assay more info	PubMed
located_in cytoplasm	IDA Inferred from Direct Assay more info	PubMed
is_active_in cytoplasm	ISO Inferred from Sequence Orthology more info
located_in cytosol	TAS Traceable Author Statement more info
located_in early endosome	ISO Inferred from Sequence Orthology more info
is_active_in extracellular space	IBA Inferred from Biological aspect of Ancestor more info
located_in extracellular space	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: granzyme B(G,H)

Names: cytotoxic cell protease 1; fragmentin-2

NP_038570.1

EC 3.4.21.79

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_013542.3 → NP_038570.1 granzyme B(G,H) preproprotein

See identical proteins and their annotated locations for NP_038570.1

Status: REVIEWED

Source sequence(s)

AC091783, AK157856, BU758224, BY227723

Consensus CDS

CCDS27147.1

UniProtKB/Swiss-Prot

P04187

UniProtKB/TrEMBL

Q3TIP3, Q3TZH4, Q4FJY0

Related

ENSMUSP00000015581.5, ENSMUST00000015581.6

Conserved Domains (2) summary

smart00020
Location:20 → 240

Tryp_SPc; Trypsin-like serine protease

cd00190
Location:21 → 243

Tryp_SPc; Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad ...