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Hells helicase, lymphoid specific [ Mus musculus (house mouse) ]

Gene ID: 15201, updated on 14-Nov-2024

Summary

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Official Symbol
Hellsprovided by MGI
Official Full Name
helicase, lymphoid specificprovided by MGI
Primary source
MGI:MGI:106209
See related
Ensembl:ENSMUSG00000025001 AllianceGenome:MGI:106209
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
LSH; Lysh; PASG; YFK8; E130115I21Rik
Summary
Enables chromatin binding activity. Involved in kidney development; lymphocyte proliferation; and negative regulation of gene expression, epigenetic. Acts upstream of or within several processes, including cellular response to leukemia inhibitory factor; chromosomal DNA methylation maintenance following DNA replication; and negative regulation of intrinsic apoptotic signaling pathway. Located in nucleus and pericentric heterochromatin. Is expressed in several structures, including gut; hippocampus; neural retina; reproductive system; and thymus. Human ortholog(s) of this gene implicated in immunodeficiency-centromeric instability-facial anomalies syndrome 4. Orthologous to human HELLS (helicase, lymphoid specific). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Biased expression in CNS E11.5 (RPKM 12.2), liver E14 (RPKM 8.5) and 10 other tissues See more
Orthologs
human all
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Genomic context

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See Hells in Genome Data Viewer
Location:
19 C3; 19 33.57 cM
Exon count:
23
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 19 NC_000085.7 (38913282..38958914)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 19 NC_000085.6 (38930262..38970470)

Chromosome 19 - NC_000085.7Genomic Context describing neighboring genes Neighboring gene NOC3 like DNA replication regulator Neighboring gene TBC1D12: TBC1 domain family, member 12 Neighboring gene STARR-seq mESC enhancer starr_46100 Neighboring gene STARR-seq mESC enhancer starr_46102 Neighboring gene cytochrome P450, family 2, subfamily c, polypeptide 52, pseudogene Neighboring gene STARR-seq mESC enhancer starr_46105 Neighboring gene STARR-seq mESC enhancer starr_46106 Neighboring gene cytochrome P450, family 2, subfamily c, polypeptide 55

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Lymphoid-specific helicase (HELLS) is essential for meiotic progression in mouse spermatocytes. Zeng W, et al. Biol Reprod, 2011 Jun. PMID 21349825, Free PMC Article
  2. Germinal center output is sustained by HELLS-dependent DNA-methylation-maintenance in B cells. Cousu C, et al. Nat Commun, 2023 Sep 14. PMID 37709749, Free PMC Article
  3. DNA hypomethylation caused by Lsh deletion promotes erythroleukemia development. Fan T, et al. Epigenetics, 2008 May-Jun. PMID 18487951, Free PMC Article
  4. Lsh is required for meiotic chromosome synapsis and retrotransposon silencing in female germ cells. De La Fuente R, et al. Nat Cell Biol, 2006 Dec. PMID 17115026
  5. CG hypomethylation in Lsh-/- mouse embryonic fibroblasts is associated with de novo H3K4me1 formation and altered cellular plasticity. Yu W, et al. Proc Natl Acad Sci U S A, 2014 Apr 22. PMID 24711395, Free PMC Article

See all (74) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Germinal center output is sustained by HELLS-dependent DNA-methylation-maintenance in B cells.
    Title: Germinal center output is sustained by HELLS-dependent DNA-methylation-maintenance in B cells.
  2. Chromatin remodelers HELLS, WDHD1 and BAZ1A are dynamically expressed during mouse spermatogenesis.
    Title: Chromatin remodelers HELLS, WDHD1 and BAZ1A are dynamically expressed during mouse spermatogenesis.
  3. PRDM9 activity depends on HELLS and promotes local 5-hydroxymethylcytosine enrichment.
    Title: PRDM9 activity depends on HELLS and promotes local 5-hydroxymethylcytosine enrichment.
  4. LSH mediates gene repression through macroH2A deposition.
    Title: LSH mediates gene repression through macroH2A deposition.
  5. The ZBTB24-CDCA7 axis regulates HELLS enrichment at centromeric satellite repeats to facilitate DNA methylation.
    Title: The ZBTB24-CDCA7 axis regulates HELLS enrichment at centromeric satellite repeats to facilitate DNA methylation.
  6. Lsh/HELLS is required for B lymphocyte development and immunoglobulin class switch recombination.
    Title: Lsh/HELLS is required for B lymphocyte development and immunoglobulin class switch recombination.
  7. Helicase LSH/Hells regulates kinetochore function, histone H3/Thr3 phosphorylation and centromere transcription during oocyte meiosis.
    Title: Helicase LSH/Hells regulates kinetochore function, histone H3/Thr3 phosphorylation and centromere transcription during oocyte meiosis.
  8. By altering the nucleosome occupancy at the nucleosome-free region and enhancer, HELLS epigenetically suppresses multiple tumor suppressor genes to promote hepatocellular carcinoma progression.
    Title: HELLS Regulates Chromatin Remodeling and Epigenetic Silencing of Multiple Tumor Suppressor Genes in Human Hepatocellular Carcinoma.
  9. hot spot activation in which HELLS and PRDM9 form a pioneer complex to create a unique epigenomic environment of open chromatin, permitting correct placement and repair of DSBs
    Title: HELLS and PRDM9 form a pioneer complex to open chromatin at meiotic recombination hot spots.
  10. Lsh assists epigenetic gene repression upon binding to the Oct4 promoter region.
    Title: Tethering of Lsh at the Oct4 locus promotes gene repression associated with epigenetic changes.
Submit: New GeneRIF Correction See all GeneRIFs (22)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (1) 
  • Gene trapped (1) 
  • Targeted (6)  1 citation

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
  
enables chromatin binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables chromatin binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables helicase activity IEA
Inferred from Electronic Annotation
more info
  
enables hydrolase activity IEA
Inferred from Electronic Annotation
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in DNA methylation-dependent constitutive heterochromatin formation IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in DNA methylation-dependent constitutive heterochromatin formation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of apoptotic process IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in cell division IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within cellular response to leukemia inhibitory factor IEP
Inferred from Expression Pattern
more info
 PubMed 
acts_upstream_of_or_within chromatin remodeling IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within chromosomal DNA methylation maintenance following DNA replication IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within heterochromatin formation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in kidney development IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within lymphocyte differentiation TAS
Traceable Author Statement
more info
 PubMed 
involved_in lymphocyte proliferation IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in lymphocyte proliferation IEP
Inferred from Expression Pattern
more info
 PubMed 
acts_upstream_of_or_within negative regulation of apoptotic process IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in negative regulation of gene expression via chromosomal CpG island methylation IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in negative regulation of gene expression via chromosomal CpG island methylation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within negative regulation of intrinsic apoptotic signaling pathway IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in pericentric heterochromatin formation IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in pericentric heterochromatin formation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within urogenital system development IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
located_in chromosome, centromeric region IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleus IDA
Inferred from Direct Assay
more info
 PubMed 
located_in pericentric heterochromatin IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in pericentric heterochromatin IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
lymphocyte-specific helicase
Names
proliferation-associated SNF2-like protein

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_008234.3 → NP_032260.2  lymphocyte-specific helicase

    See identical proteins and their annotated locations for NP_032260.2

    Status: VALIDATED

    Source sequence(s)
    AF155210
    Consensus CDS
    CCDS29789.1
    UniProtKB/Swiss-Prot
    Q497T3, Q60848, Q8VDZ1, Q9CYV7
    Related
    ENSMUSP00000025965.6, ENSMUST00000025965.12
    Conserved Domains (2) summary
    PLN03142
    Location:204 → 781
    PLN03142; Probable chromatin-remodeling complex ATPase chain; Provisional
    cd18009
    Location:203 → 436
    DEXHc_HELLS_SMARCA6; DEXH-box helicase domain of HELLS

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000085.7 Reference GRCm39 C57BL/6J

    Range
    38913282..38958914
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006526699.5 → XP_006526762.1  lymphocyte-specific helicase isoform X1

    See identical proteins and their annotated locations for XP_006526762.1

    UniProtKB/Swiss-Prot
    Q497T3, Q60848, Q8VDZ1, Q9CYV7
    Conserved Domains (2) summary
    PLN03142
    Location:204 → 781
    PLN03142; Probable chromatin-remodeling complex ATPase chain; Provisional
    cd18009
    Location:203 → 436
    DEXHc_HELLS_SMARCA6; DEXH-box helicase domain of HELLS

  2. XM_006526700.4 → XP_006526763.1  lymphocyte-specific helicase isoform X2

    Conserved Domains (1) summary
    PLN03142
    Location:4 → 437
    PLN03142; Probable chromatin-remodeling complex ATPase chain; Provisional
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q60848.2 GenPept UniProtKB/Swiss-Prot:Q60848

Gene LinkOut

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