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ZNF827 zinc finger protein 827 [ Homo sapiens (human) ]

Gene ID: 152485, updated on 3-Nov-2024

Summary

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Official Symbol
ZNF827provided by HGNC
Official Full Name
zinc finger protein 827provided by HGNC
Primary source
HGNC:HGNC:27193
See related
Ensembl:ENSG00000151612 MIM:617962; AllianceGenome:HGNC:27193
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Summary
Enables NuRD complex binding activity. Involved in several processes, including establishment of protein localization to telomere; negative regulation of shelterin complex assembly; and telomere maintenance. Located in chromatin and chromosome, telomeric region. Part of ribonucleoprotein complex. [provided by Alliance of Genome Resources, Nov 2024]
Expression
Ubiquitous expression in prostate (RPKM 4.9), thyroid (RPKM 2.3) and 23 other tissues See more
Orthologs
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Genomic context

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See ZNF827 in Genome Data Viewer
Location:
4q31.21-q31.22
Exon count:
22
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 4 NC_000004.12 (145757627..145938823, complement)
RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 4 NC_060928.1 (149073653..149254873, complement)
RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 4 NC_000004.11 (146678779..146859975, complement)

Chromosome 4 - NC_000004.12Genomic Context describing neighboring genes Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 15731 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 15732 Neighboring gene long intergenic non-protein coding RNA 2491 Neighboring gene nuclear receptor coactivator 4 pseudogene 3 Neighboring gene metabolism of cobalamin associated A Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr4:146608063-146608617 Neighboring gene NANOG-H3K27ac hESC enhancer GRCh37_chr4:146619735-146620662 Neighboring gene H3K27ac hESC enhancer GRCh37_chr4:146620663-146621589 Neighboring gene OCT4-NANOG-H3K27ac hESC enhancer GRCh37_chr4:146624094-146624783 Neighboring gene NANOG hESC enhancer GRCh37_chr4:146625046-146625631 Neighboring gene chromosome 4 open reading frame 51 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 21965 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 21966 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 15733 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr4:146655149-146655948 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr4:146655949-146656746 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr4:146683575-146684076 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr4:146684077-146684576 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 21967 Neighboring gene P300/CBP strongly-dependent group 1 enhancer GRCh37_chr4:146729136-146730335 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 21969 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr4:146746417-146746985 Neighboring gene OCT4-NANOG-H3K27ac hESC enhancer GRCh37_chr4:146753533-146754304 Neighboring gene H3K27ac hESC enhancer GRCh37_chr4:146756877-146757401 Neighboring gene H3K27ac hESC enhancer GRCh37_chr4:146757402-146757925 Neighboring gene OCT4-NANOG-H3K27ac hESC enhancer GRCh37_chr4:146758974-146759498 Neighboring gene OCT4-NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr4:146759499-146760022 Neighboring gene H3K27ac hESC enhancer GRCh37_chr4:146799791-146800383 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 21970 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 15734 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 21971 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr4:146853271-146853772 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 15735 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 15736 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 15737 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 21972 Neighboring gene P300/CBP strongly-dependent group 1 enhancer GRCh37_chr4:146875811-146877010 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 15738 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 21973 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 21974 Neighboring gene P300/CBP strongly-dependent group 1 enhancer GRCh37_chr4:146975373-146976572 Neighboring gene uncharacterized LOC105377468 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 21976 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 21977 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 21978 Neighboring gene uncharacterized LOC105377469 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 21979 Neighboring gene long intergenic non-protein coding RNA 1095

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. Structural and functional characterization of the RBBP4-ZNF827 interaction and its role in NuRD recruitment to telomeres. Yang SF, et al. Biochem J, 2018 Aug 31. PMID 30045876
  2. Genome-wide association of individual vulnerability with alcohol-associated liver disease: A Korean genome and epidemiology study. Kim KY, et al. Hepatology, 2022 Feb. PMID 34387878, Free PMC Article
  3. Scan of human genome reveals no new Loci under ancient balancing selection. Bubb KL, et al. Genetics, 2006 Aug. PMID 16751668, Free PMC Article
  4. circZNF827 nucleates a transcription inhibitory complex to balance neuronal differentiation. Hollensen AK, et al. Elife, 2020 Nov 11. PMID 33174841, Free PMC Article
  5. NuRD-ZNF827 recruitment to telomeres creates a molecular scaffold for homologous recombination. Conomos D, et al. Nat Struct Mol Biol, 2014 Sep. PMID 25150861

See all (30) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Genome-wide association of individual vulnerability with alcohol-associated liver disease: A Korean genome and epidemiology study.
    Title: Genome-wide association of individual vulnerability with alcohol-associated liver disease: A Korean genome and epidemiology study.
  2. RBBP4 forms a negatively charged channel that binds to ZNF827 through a network of electrostatic interactions.
    Title: Structural and functional characterization of the RBBP4-ZNF827 interaction and its role in NuRD recruitment to telomeres.
  3. NuRD-ZNF827 recruitment to human telomeres causes remodeling of telomeric chromatin and creates an environment that promotes telomere-telomere recombination and integrates and controls multiple elements of Alternative lengthening of telomeres activity.
    Title: NuRD-ZNF827 recruitment to telomeres creates a molecular scaffold for homologous recombination.
  4. Clinical trial of gene-disease association and gene-environment interaction. (HuGE Navigator)
    Title: Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score.
  5. Observational study of gene-disease association. (HuGE Navigator)
    Title: Coeliac disease-associated risk variants in TNFAIP3 and REL implicate altered NF-kappaB signalling.
Submit: New GeneRIF Correction

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

EBI GWAS Catalog

Description
A genome-wide association study of behavioral disinhibition.
EBI GWAS Catalog
Genome-wide analysis of polymorphisms associated with cytokine responses in smallpox vaccine recipients.
EBI GWAS Catalog
Genome-wide association study identifies loci influencing concentrations of liver enzymes in plasma.
EBI GWAS Catalog
GWAS of dental caries patterns in the permanent dentition.
EBI GWAS Catalog
Large-scale genome-wide association studies in East Asians identify new genetic loci influencing metabolic traits.
EBI GWAS Catalog

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables DNA binding IEA
Inferred from Electronic Annotation
more info
  
enables NuRD complex binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in chromatin remodeling IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in establishment of protein localization to telomere IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in negative regulation of DNA-templated transcription IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in negative regulation of shelterin complex assembly IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in positive regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in telomere maintenance IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
located_in chromatin IDA
Inferred from Direct Assay
more info
 PubMed 
located_in chromosome, telomeric region IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of ribonucleoprotein complex IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
zinc finger protein 827

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001306215.2 → NP_001293144.1  zinc finger protein 827 isoform 1

    See identical proteins and their annotated locations for NP_001293144.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents longer isoform (1).
    Source sequence(s)
    AK091130, AK094136, AK225805, BC033248, BU616184, BX112429
    Consensus CDS
    CCDS77968.1
    UniProtKB/Swiss-Prot
    B7ZL52, Q17R98, Q7Z4S7, Q8N279
    UniProtKB/TrEMBL
    A0A494C0H4
    Related
    ENSP00000421863.1, ENST00000508784.6
    Conserved Domains (4) summary
    COG5048
    Location:355 → 443
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:376 → 396
    ZF_C2H2; C2H2 Zn finger [structural motif]
    sd00019
    Location:819 → 839
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam13465
    Location:388 → 413
    zf-H2C2_2; Zinc-finger double domain

  2. NM_001410850.1 → NP_001397779.1  zinc finger protein 827 isoform 3

    Status: VALIDATED

    Source sequence(s)
    AC104791, AC107212
    Consensus CDS
    CCDS93645.1
    UniProtKB/TrEMBL
    H0Y9M2
    Related
    ENSP00000424541.2, ENST00000503462.3

  3. NM_178835.5 → NP_849157.2  zinc finger protein 827 isoform 2

    See identical proteins and their annotated locations for NP_849157.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 3' UTR and uses an alternate splice site that results in a shorter 3' coding region compared to variant 1. It encodes isoform 2, which has a shorter C-terminus compared to isoform 1.
    Source sequence(s)
    AK091130, AK094136, AK225805, BC033248, BC117407, BM557137, BU616184, BX112429
    Consensus CDS
    CCDS34072.1
    UniProtKB/TrEMBL
    A0A494C0H4
    Related
    ENSP00000368761.4, ENST00000379448.9
    Conserved Domains (4) summary
    COG5048
    Location:355 → 443
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:376 → 396
    ZF_C2H2; C2H2 Zn finger [structural motif]
    sd00019
    Location:819 → 839
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam13465
    Location:388 → 413
    zf-H2C2_2; Zinc-finger double domain

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000004.12 Reference GRCh38.p14 Primary Assembly

    Range
    145757627..145938823 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_047449635.1 → XP_047305591.1  zinc finger protein 827 isoform X4

  2. XM_017007768.3 → XP_016863257.1  zinc finger protein 827 isoform X1

  3. XM_017007770.3 → XP_016863259.1  zinc finger protein 827 isoform X3

  4. XM_047449634.1 → XP_047305590.1  zinc finger protein 827 isoform X2

  5. XM_047449636.1 → XP_047305592.1  zinc finger protein 827 isoform X5

  6. XM_011531635.3 → XP_011529937.1  zinc finger protein 827 isoform X2

    See identical proteins and their annotated locations for XP_011529937.1

    Conserved Domains (4) summary
    COG5048
    Location:343 → 431
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:364 → 384
    ZF_C2H2; C2H2 Zn finger [structural motif]
    sd00019
    Location:807 → 827
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam13465
    Location:1134 → 1158
    zf-H2C2_2; Zinc-finger double domain

  7. XM_017007769.2 → XP_016863258.1  zinc finger protein 827 isoform X2

    Conserved Domains (4) summary
    COG5048
    Location:343 → 431
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:364 → 384
    ZF_C2H2; C2H2 Zn finger [structural motif]
    sd00019
    Location:807 → 827
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam13465
    Location:1134 → 1158
    zf-H2C2_2; Zinc-finger double domain

  8. XM_017007777.3 → XP_016863266.1  zinc finger protein 827 isoform X12

    Conserved Domains (3) summary
    sd00017
    Location:516 → 536
    ZF_C2H2; C2H2 Zn finger [structural motif]
    sd00019
    Location:230 → 250
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam13465
    Location:557 → 581
    zf-H2C2_2; Zinc-finger double domain

  9. XM_011531645.3 → XP_011529947.1  zinc finger protein 827 isoform X13

    Conserved Domains (3) summary
    sd00017
    Location:437 → 457
    ZF_C2H2; C2H2 Zn finger [structural motif]
    sd00019
    Location:151 → 171
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam13465
    Location:478 → 502
    zf-H2C2_2; Zinc-finger double domain

  10. XM_047449637.1 → XP_047305593.1  zinc finger protein 827 isoform X6

    Related
    ENSP00000498532.1, ENST00000652097.1

  11. XM_047449638.1 → XP_047305594.1  zinc finger protein 827 isoform X7

  12. XM_047449639.1 → XP_047305595.1  zinc finger protein 827 isoform X9

  13. XM_017007775.3 → XP_016863264.1  zinc finger protein 827 isoform X8

    UniProtKB/TrEMBL
    A0A494C0H4
    Related
    ENSP00000499364.1, ENST00000656985.1
    Conserved Domains (4) summary
    COG5048
    Location:355 → 443
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:376 → 396
    ZF_C2H2; C2H2 Zn finger [structural motif]
    sd00019
    Location:819 → 839
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam13465
    Location:388 → 413
    zf-H2C2_2; Zinc-finger double domain

  14. XM_017007776.3 → XP_016863265.1  zinc finger protein 827 isoform X11

  15. XM_047449640.1 → XP_047305596.1  zinc finger protein 827 isoform X10

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060928.1 Alternate T2T-CHM13v2.0

    Range
    149073653..149254873 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054348978.1 → XP_054204953.1  zinc finger protein 827 isoform X4

  2. XM_054348975.1 → XP_054204950.1  zinc finger protein 827 isoform X1

  3. XM_054348977.1 → XP_054204952.1  zinc finger protein 827 isoform X3

  4. XM_054348976.1 → XP_054204951.1  zinc finger protein 827 isoform X2

  5. XM_054348979.1 → XP_054204954.1  zinc finger protein 827 isoform X5

  6. XM_054348986.1 → XP_054204961.1  zinc finger protein 827 isoform X12

  7. XM_054348987.1 → XP_054204962.1  zinc finger protein 827 isoform X13

  8. XM_054348980.1 → XP_054204955.1  zinc finger protein 827 isoform X6

  9. XM_054348981.1 → XP_054204956.1  zinc finger protein 827 isoform X7

  10. XM_054348983.1 → XP_054204958.1  zinc finger protein 827 isoform X9

  11. XM_054348982.1 → XP_054204957.1  zinc finger protein 827 isoform X8

  12. XM_054348985.1 → XP_054204960.1  zinc finger protein 827 isoform X11

  13. XM_054348984.1 → XP_054204959.1  zinc finger protein 827 isoform X10

Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q17R98.1 GenPept UniProtKB/Swiss-Prot:Q17R98

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