Hint1 histidine triad nucleotide binding protein 1 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Hint1provided by MGI
Official Full Name: histidine triad nucleotide binding protein 1provided by MGI
Primary source: MGI:MGI:1321133
See related: Ensembl:ENSMUSG00000020267 AllianceGenome:MGI:1321133
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Hint; Ipk1; PKCI-1; PRKCNH1
Summary: Enables deSUMOylase activity. Involved in positive regulation of calcium-mediated signaling and protein desumoylation. Located in nucleus. Is expressed in several structures, including genitourinary system; gut; mammary gland; nervous system; and spleen. Human ortholog(s) of this gene implicated in Gamstorp-Wohlfart syndrome. Orthologous to human HINT1 (histidine triad nucleotide binding protein 1). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Ubiquitous expression in kidney adult (RPKM 346.0), duodenum adult (RPKM 283.7) and 28 other tissues See more
Orthologs: human all
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Genomic context

Location:: 11 B1.3; 11 32.13 cM

Exon count:: 3

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	11	NC_000077.7 (54757209..54761332)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	11	NC_000077.6 (54866383..54870506)

Chromosome 11 - NC_000077.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

USP40 deubiquitinates HINT1 and stabilizes p53 in podocyte damage.
Title: USP40 deubiquitinates HINT1 and stabilizes p53 in podocyte damage.
HINT1 deficiency in aged mice reduces anxiety-like and depression-like behaviours and enhances cognitive performances.
Title: HINT1 deficiency in aged mice reduces anxiety-like and depression-like behaviours and enhances cognitive performances.
HINT1 (Histidine Triad Nucleotide-Binding Protein 1) Attenuates Cardiac Hypertrophy Via Suppressing HOXA5 (Homeobox A5) Expression.
Title: HINT1 (Histidine Triad Nucleotide-Binding Protein 1) Attenuates Cardiac Hypertrophy Via Suppressing HOXA5 (Homeobox A5) Expression.
Does genetic mouse model of constitutive Hint1 deficiency exhibit schizophrenia-like behaviors?
Title: Does genetic mouse model of constitutive Hint1 deficiency exhibit schizophrenia-like behaviors?
The role of HINT1 in methamphetamine-induced behavioral sensitization.
Title: The role of HINT1 in methamphetamine-induced behavioral sensitization.
The human HINT1 mutants reported to cause ARAN-NM all exhibited deficiencies in their sumoylase activity, thus suggesting a role for HINT1 isopeptidase activity in the pathogenesis of this human motor disease.
Title: The Axonal Motor Neuropathy-Related HINT1 Protein Is a Zinc- and Calmodulin-Regulated Cysteine SUMO Protease.
Increased PKC activity and altered GSK3B/NMDAR function drive behavior cycling in HINT1-deficient mice.
Title: Increased PKC activity and altered GSK3β/NMDAR function drive behavior cycling in HINT1-deficient mice: bipolarity or opposing forces.
Study shows that social isolation to a series of schizophrenia-related deficits and that potential interactions among histidine triad nucleotide binding protein 1, NMDA receptor 1, and dopamine receptor 2 may underlie the behavioral deficits induced by social isolation.
Title: Social isolation induces schizophrenia-like behavior potentially associated with HINT1, NMDA receptor 1, and dopamine receptor 2.
The absence of Hint1 gene enhances supraspinal nociceptive sensitivity in mice, including thermal, mechanical and inflammatory hyperalgesia.
Title: Hint1 gene deficiency enhances the supraspinal nociceptive sensitivity in mice.
It was observed that HINT1 protein binds to GPCRs and NMDAR NR1 subunits in a calcium-independent manner, whereas sigma1R binding to these proteins increases in the presence of calcium.
Title: The ON:OFF switch, σ1R-HINT1 protein, controls GPCR-NMDA receptor cross-regulation: implications in neurological disorders.

Submit: New GeneRIF Correction See all GeneRIFs (32)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (2)
Targeted (5) 1 citation

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

AA673479 (e-PCR)
- UniSTS:185882

PMC164672P1 (e-PCR)
- UniSTS:271511

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables adenosine 5'-monophosphoramidase activity	ISO Inferred from Sequence Orthology more info
enables adenosine 5'-monophosphoramidase activity	ISS Inferred from Sequence or Structural Similarity more info
enables deSUMOylase activity	IDA Inferred from Direct Assay more info	PubMed
enables deSUMOylase activity	ISO Inferred from Sequence Orthology more info
enables hydrolase activity	IBA Inferred from Biological aspect of Ancestor more info
enables hydrolase activity	ISO Inferred from Sequence Orthology more info
enables hydrolase activity	ISS Inferred from Sequence or Structural Similarity more info
enables nucleotide binding	IEA Inferred from Electronic Annotation more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
involved_in intrinsic apoptotic signaling pathway by p53 class mediator	ISO Inferred from Sequence Orthology more info
involved_in intrinsic apoptotic signaling pathway by p53 class mediator	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of calcium-mediated signaling	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in protein desumoylation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in protein desumoylation	ISO Inferred from Sequence Orthology more info
involved_in proteolysis	IEA Inferred from Electronic Annotation more info
involved_in purine ribonucleotide catabolic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in purine ribonucleotide catabolic process	ISO Inferred from Sequence Orthology more info
involved_in purine ribonucleotide catabolic process	ISS Inferred from Sequence or Structural Similarity more info
involved_in regulation of DNA-templated transcription	ISO Inferred from Sequence Orthology more info
involved_in regulation of DNA-templated transcription	ISS Inferred from Sequence or Structural Similarity more info

Component	Evidence Code	Pubs
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in cytoplasm	ISO Inferred from Sequence Orthology more info
located_in cytoplasm	ISS Inferred from Sequence or Structural Similarity more info
located_in cytosol	IEA Inferred from Electronic Annotation more info
located_in cytosol	ISO Inferred from Sequence Orthology more info
part_of histone deacetylase complex	ISO Inferred from Sequence Orthology more info
part_of histone deacetylase complex	ISS Inferred from Sequence or Structural Similarity more info
located_in nucleoplasm	ISO Inferred from Sequence Orthology more info
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleus	IDA Inferred from Direct Assay more info	PubMed
located_in nucleus	ISO Inferred from Sequence Orthology more info
located_in plasma membrane	IEA Inferred from Electronic Annotation more info
located_in plasma membrane	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: adenosine 5'-monophosphoramidase HINT1

Names: PKC inhibitor/ interacting protein; adenosine 5'-monophosphoramidase; desumoylating isopeptidase HINT1; protein kinase C inhibitor 1; protein kinase C-interacting protein 1

NP_032274.1

EC 3.-.-.-

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_008248.3 → NP_032274.1 adenosine 5'-monophosphoramidase HINT1

See identical proteins and their annotated locations for NP_032274.1

Status: VALIDATED

Source sequence(s)

BC070415, BE995722, BY261801

Consensus CDS

CCDS24702.1

UniProtKB/Swiss-Prot

P70349

Related

ENSMUSP00000020504.6, ENSMUST00000020504.6

Conserved Domains (1) summary

cd01276
Location:16 → 118

PKCI_related; Protein Kinase C Interacting protein related (PKCI): PKCI and related proteins belong to the ubiquitous HIT family of hydrolases that act on alpha-phosphates of ribonucleotides. The members of this subgroup have a conserved HxHxHxx motif (x is a ...