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Hmgb3 high mobility group box 3 [ Mus musculus (house mouse) ]

Gene ID: 15354, updated on 9-Dec-2024

Summary

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Official Symbol
Hmgb3provided by MGI
Official Full Name
high mobility group box 3provided by MGI
Primary source
MGI:MGI:1098219
See related
Ensembl:ENSMUSG00000015217 AllianceGenome:MGI:1098219
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Hmg4; Hmg2a
Summary
Enables DNA binding activity and RNA binding activity. Acts upstream of or within negative regulation of B cell differentiation and negative regulation of myeloid cell differentiation. Located in nucleus. Is expressed in several structures, including central nervous system; ear; genitourinary system; liver; and retina. Human ortholog(s) of this gene implicated in syndromic microphthalmia 13. Orthologous to human HMGB3 (high mobility group box 3). [provided by Alliance of Genome Resources, Dec 2024]
Expression
Biased expression in CNS E11.5 (RPKM 187.0), CNS E14 (RPKM 108.6) and 11 other tissues See more
Orthologs
human all
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Genomic context

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See Hmgb3 in Genome Data Viewer
Location:
X A7.3; X 36.92 cM
Exon count:
7
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) X NC_000086.8 (70599523..70604261)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) X NC_000086.7 (71555917..71560673)

Chromosome X - NC_000086.8Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_47324 Neighboring gene CD99 antigen-like 2 Neighboring gene ribosomal protein L36 pseudogene Neighboring gene STARR-positive B cell enhancer mm9_chrX:68808842-68809143 Neighboring gene STARR-seq mESC enhancer starr_47325 Neighboring gene STARR-seq mESC enhancer starr_47326 Neighboring gene G-protein-coupled receptor 50 Neighboring gene ribosomal protein L30, pseudogene 10

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Hmgb3 deficiency deregulates proliferation and differentiation of common lymphoid and myeloid progenitors. Nemeth MJ, et al. Blood, 2005 Jan 15. PMID 15358624
  2. Hmgb3 regulates the balance between hematopoietic stem cell self-renewal and differentiation. Nemeth MJ, et al. Proc Natl Acad Sci U S A, 2006 Sep 12. PMID 16945912, Free PMC Article
  3. Isolation of human and mouse HMG2a cDNAs: evidence for an HMG2a-specific 3' untranslated region. Wilke K, et al. Gene, 1997 Oct 1. PMID 9370291
  4. Hmgb3 Induces the Differentiation of Uterine Stromal Cells Through Targeting Ptn. Wang K, et al. Reprod Sci, 2019 Jul. PMID 30081728
  5. Overexpression of the HMGA2 gene in transgenic mice leads to the onset of pituitary adenomas. Fedele M, et al. Oncogene, 2002 May 9. PMID 12082634

See all (43) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Hmgb3 may play an important role during embryo implantation and decidualization. Pleiotropin is a downstream target of Hmgb3 in the differentiation of uterine stromal cells.
    Title: Hmgb3 Induces the Differentiation of Uterine Stromal Cells Through Targeting Ptn.
  2. Data indicate that myomiR-206 modulates Hmgb3 expression during myogenesis.
    Title: Hmgb3 is regulated by microRNA-206 during muscle regeneration.
  3. Regulation of transcription factor Twist expression by the DNA architectural protein high mobility group A2 during epithelial-to-mesenchymal transition.
    Title: Regulation of transcription factor Twist expression by the DNA architectural protein high mobility group A2 during epithelial-to-mesenchymal transition.
  4. Hmgb3 deficiency leads to a failure of hematopoietic stem cells to expand into normal numbers of lymphoid progenitor and myeloid progenitors
    Title: Hmgb3 deficiency deregulates proliferation and differentiation of common lymphoid and myeloid progenitors.
  5. Hmgb3 is required for the proper balance between hematopoietic stem cell self-renewal and differentiation.
    Title: Hmgb3 regulates the balance between hematopoietic stem cell self-renewal and differentiation.
  6. Overexpression of the HMGA2 gene in transgenic mice leads to the onset of mixed growth hormone/prolactin cell pituitary adenomas.
    Title: Overexpression of the HMGA2 gene in transgenic mice leads to the onset of pituitary adenomas.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (4) 
  • Targeted (2)  1 citation

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables DNA binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables DNA binding, bending ISS
Inferred from Sequence or Structural Similarity
more info
  
enables RNA binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables four-way junction DNA binding ISS
Inferred from Sequence or Structural Similarity
more info
  
Process Evidence Code Pubs
involved_in DNA geometric change ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in innate immune response IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within negative regulation of B cell differentiation IDA
Inferred from Direct Assay
more info
 PubMed 
acts_upstream_of_or_within negative regulation of myeloid cell differentiation IDA
Inferred from Direct Assay
more info
 PubMed 
Component Evidence Code Pubs
located_in chromosome IEA
Inferred from Electronic Annotation
more info
  
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in nucleus IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
high mobility group protein B3
Names
high mobility group protein 2a
high mobility group protein 4
high mobilty group protein 2A

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001293623.2 → NP_001280552.1  high mobility group protein B3 isoform 1

    See identical proteins and their annotated locations for NP_001280552.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longest transcript. Variants 1, 2, 3, and 4 encode the same protein.
    Source sequence(s)
    AL833776
    Consensus CDS
    CCDS30180.1
    UniProtKB/Swiss-Prot
    O54879
    UniProtKB/TrEMBL
    Q544R9
    Related
    ENSMUSP00000086260.4, ENSMUST00000088874.10
    Conserved Domains (2) summary
    pfam00505
    Location:93 → 160
    HMG_box; HMG (high mobility group) box
    pfam09011
    Location:13 → 78
    HMG_box_2; HMG-box domain

  2. NM_001293624.2 → NP_001280553.1  high mobility group protein B3 isoform 1

    See identical proteins and their annotated locations for NP_001280553.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) differs in the 5' UTR, compared to variant 1. Variants 1, 2, 3, and 4 encode the same protein.
    Source sequence(s)
    AL833776
    Consensus CDS
    CCDS30180.1
    UniProtKB/Swiss-Prot
    O54879
    UniProtKB/TrEMBL
    Q544R9
    Related
    ENSMUSP00000110232.3, ENSMUST00000072699.13
    Conserved Domains (2) summary
    pfam00505
    Location:93 → 160
    HMG_box; HMG (high mobility group) box
    pfam09011
    Location:13 → 78
    HMG_box_2; HMG-box domain

  3. NM_001293625.2 → NP_001280554.1  high mobility group protein B3 isoform 1

    See identical proteins and their annotated locations for NP_001280554.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (4) differs in the 5' UTR, compared to variant 1. Variants 1, 2, 3, and 4 encode the same protein.
    Source sequence(s)
    AL833776
    Consensus CDS
    CCDS30180.1
    UniProtKB/Swiss-Prot
    O54879
    UniProtKB/TrEMBL
    Q544R9
    Related
    ENSMUSP00000015361.5, ENSMUST00000015361.11
    Conserved Domains (2) summary
    pfam00505
    Location:93 → 160
    HMG_box; HMG (high mobility group) box
    pfam09011
    Location:13 → 78
    HMG_box_2; HMG-box domain

  4. NM_001411295.1 → NP_001398224.1  high mobility group protein B3 isoform 1

    Status: VALIDATED

    Source sequence(s)
    AL833776
    UniProtKB/Swiss-Prot
    O54879
    UniProtKB/TrEMBL
    Q544R9

  5. NM_001411296.1 → NP_001398225.1  high mobility group protein B3 isoform 1

    Status: VALIDATED

    Source sequence(s)
    AL833776
    UniProtKB/Swiss-Prot
    O54879
    UniProtKB/TrEMBL
    Q544R9

  6. NM_001411299.1 → NP_001398228.1  high mobility group protein B3 isoform 1

    Status: VALIDATED

    Source sequence(s)
    AL833776
    UniProtKB/Swiss-Prot
    O54879
    UniProtKB/TrEMBL
    Q544R9

  7. NM_001411300.1 → NP_001398229.1  high mobility group protein B3 isoform 2

    Status: VALIDATED

    Source sequence(s)
    AL833776

  8. NM_001411301.1 → NP_001398230.1  high mobility group protein B3 isoform 3

    Status: VALIDATED

    Source sequence(s)
    AL833776

  9. NM_001411302.1 → NP_001398231.1  high mobility group protein B3 isoform 3

    Status: VALIDATED

    Source sequence(s)
    AL833776

  10. NM_001411303.1 → NP_001398232.1  high mobility group protein B3 isoform 3

    Status: VALIDATED

    Source sequence(s)
    AL833776

  11. NM_008253.5 → NP_032279.1  high mobility group protein B3 isoform 1

    See identical proteins and their annotated locations for NP_032279.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR, compared to variant 1. Variants 1, 2, 3, and 4 encode the same protein.
    Source sequence(s)
    AL833776
    Consensus CDS
    CCDS30180.1
    UniProtKB/Swiss-Prot
    O54879
    UniProtKB/TrEMBL
    Q544R9
    Related
    ENSMUSP00000110229.3, ENSMUST00000114582.9
    Conserved Domains (2) summary
    pfam00505
    Location:93 → 160
    HMG_box; HMG (high mobility group) box
    pfam09011
    Location:13 → 78
    HMG_box_2; HMG-box domain

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000086.8 Reference GRCm39 C57BL/6J

    Range
    70599523..70604261
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006527842.5 → XP_006527905.1  high mobility group protein B3 isoform X1

    See identical proteins and their annotated locations for XP_006527905.1

    UniProtKB/Swiss-Prot
    O54879
    UniProtKB/TrEMBL
    Q544R9
    Conserved Domains (2) summary
    pfam00505
    Location:93 → 160
    HMG_box; HMG (high mobility group) box
    pfam09011
    Location:13 → 78
    HMG_box_2; HMG-box domain
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
O54879.3 GenPept UniProtKB/Swiss-Prot:O54879

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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