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Ifi204 interferon activated gene 204 [ Mus musculus (house mouse) ]

Gene ID: 15951, updated on 14-May-2024

Summary

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Official Symbol
Ifi204provided by MGI
Official Full Name
interferon activated gene 204provided by MGI
Primary source
MGI:MGI:96429
See related
Ensembl:ENSMUSG00000073489 AllianceGenome:MGI:96429
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
p204; Ifi16
Summary
Enables double-stranded DNA binding activity and transcription coregulator activity. Involved in cellular response to interferon-alpha. Acts upstream of or within several processes, including cellular response to interferon-beta; inner ear development; and positive regulation of osteoblast differentiation. Located in nuclear inclusion body and nucleolus. Is expressed in esophagus; male reproductive gland or organ; and tibia. Orthologous to human IFI16 (interferon gamma inducible protein 16). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in liver E18 (RPKM 7.6), bladder adult (RPKM 3.1) and 13 other tissues See more
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Genomic context

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See Ifi204 in Genome Data Viewer
Location:
1 H3; 1 80.63 cM
Exon count:
9
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 1 NC_000067.7 (173574859..173594606, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 1 NC_000067.6 (173747293..173767069, complement)

Chromosome 1 - NC_000067.7Genomic Context describing neighboring genes Neighboring gene predicted gene 7871 Neighboring gene interferon activated gene 207 Neighboring gene interferon activated gene 203, pseudogene Neighboring gene STARR-positive B cell enhancer mm9_chr1:175731887-175732188 Neighboring gene STARR-positive B cell enhancer mm9_chr1:175783692-175783993 Neighboring gene STARR-seq mESC enhancer starr_03084 Neighboring gene myeloid nuclear differentiation antigen like Neighboring gene STARR-positive B cell enhancer ABC_E801

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. IFI204 protects host defense against Staphylococcus aureus-induced pneumonia by promoting extracellular traps formation. Zhang JG, et al. Exp Cell Res, 2023 Jan 1. PMID 36379277
  2. Interferon-gamma inducible protein 16 and type I interferon receptors expression in experimental apical periodontitis induced in wild-type mice. Pucinelli CM, et al. Int Endod J, 2022 Oct. PMID 35869806
  3. Structural mechanism of DNA recognition by the p204 HIN domain. Fan X, et al. Nucleic Acids Res, 2021 Mar 18. PMID 33619523, Free PMC Article
  4. P200 family protein IFI204 negatively regulates type I interferon responses by targeting IRF7 in nucleus. Cao L, et al. PLoS Pathog, 2019 Oct. PMID 31603949, Free PMC Article
  5. DNA Sensor IFI204 Contributes to Host Defense Against Staphylococcus aureus Infection in Mice. Chen W, et al. Front Immunol, 2019. PMID 30936875, Free PMC Article

See all (65) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. IFI204 protects host defense against Staphylococcus aureus-induced pneumonia by promoting extracellular traps formation.
    Title: IFI204 protects host defense against Staphylococcus aureus-induced pneumonia by promoting extracellular traps formation.
  2. Interferon activated gene 204 protects against bone loss in experimental periodontitis.
    Title: Interferon activated gene 204 protects against bone loss in experimental periodontitis.
  3. Interferon-gamma inducible protein 16 and type I interferon receptors expression in experimental apical periodontitis induced in wild-type mice.
    Title: Interferon-gamma inducible protein 16 and type I interferon receptors expression in experimental apical periodontitis induced in wild-type mice.
  4. Structural mechanism of DNA recognition by the p204 HIN domain.
    Title: Structural mechanism of DNA recognition by the p204 HIN domain.
  5. SENP3 senses oxidative stress to facilitate STING-dependent dendritic cell antitumor function.
    Title: SENP3 senses oxidative stress to facilitate STING-dependent dendritic cell antitumor function.
  6. DNA Sensor IFI204 Contributes to Host Defense Against Staphylococcus aureus Infection in Mice.
    Title: DNA Sensor IFI204 Contributes to Host Defense Against Staphylococcus aureus Infection in Mice.
  7. Silencing of Ifi204/p204 induces resistance to IFNgamma-mediated cell growth arrest in SCCVII cells.
    Title: Silencing of the interferon-inducible gene Ifi204/p204 induces resistance to interferon-γ-mediated cell growth arrest of tumor cells.
  8. The results reveal that the interferon-inducible IFI204 could negatively regulate the IRF7-mediated type I interferon response after RNA virus infection to avoid unnecessary host damage from hyper-inflammatory responses.
    Title: P200 family protein IFI204 negatively regulates type I interferon responses by targeting IRF7 in nucleus.
  9. p204 is a critical component of canonical LPS-TLR4 signaling pathway, and these studies also suggest that p204 could be a potential target to prevent and treat inflammatory and infectious diseases.
    Title: p204 Is Required for Canonical Lipopolysaccharide-induced TLR4 Signaling in Mice.
  10. Importantly, knocking down p204, which is reported as the mouse orthologous of human IFI16, inhibited epidermal hyperplasia in mice with imiquimod-induced psoriasiform dermatitis. These findings indicate that IFI16 plays a critical role in the pathogenesis of psoriasis and may be a potential therapeutic target
    Title: Up-regulation of Interferon-inducible protein 16 contributes to psoriasis by modulating chemokine production in keratinocytes.
Submit: New GeneRIF Correction See all GeneRIFs (28)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (3) 
  • Targeted (7)  1 citation

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables DNA binding IEA
Inferred from Electronic Annotation
more info
  
enables double-stranded DNA binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables double-stranded DNA binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables double-stranded DNA binding ISO
Inferred from Sequence Orthology
more info
  
enables identical protein binding ISO
Inferred from Sequence Orthology
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables transcription coregulator activity IGI
Inferred from Genetic Interaction
more info
 PubMed 
enables transcription factor binding ISO
Inferred from Sequence Orthology
more info
  
enables ubiquitin protein ligase binding ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in activation of innate immune response IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in cellular response to interferon-alpha IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in cellular response to interferon-beta IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within cellular response to interferon-beta IDA
Inferred from Direct Assay
more info
 PubMed 
acts_upstream_of_or_within immune system process IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within innate immune response IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within inner ear development IDA
Inferred from Direct Assay
more info
 PubMed 
acts_upstream_of_or_within intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator ISO
Inferred from Sequence Orthology
more info
 PubMed 
acts_upstream_of_or_within multicellular organism development IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within positive regulation of osteoblast differentiation IGI
Inferred from Genetic Interaction
more info
 PubMed 
acts_upstream_of_or_within regulation of transcription by RNA polymerase II IDA
Inferred from Direct Assay
more info
 PubMed 
acts_upstream_of_or_within response to bacterium IEP
Inferred from Expression Pattern
more info
 PubMed 
Component Evidence Code Pubs
is_active_in cytoplasm ISO
Inferred from Sequence Orthology
more info
  
is_active_in cytosol IBA
Inferred from Biological aspect of Ancestor
more info
  
colocalizes_with cytosol ISO
Inferred from Sequence Orthology
more info
  
located_in cytosol ISO
Inferred from Sequence Orthology
more info
  
located_in intracellular membrane-bounded organelle ISO
Inferred from Sequence Orthology
more info
  
located_in nuclear inclusion body IDA
Inferred from Direct Assay
more info
 PubMed 
located_in nuclear speck ISO
Inferred from Sequence Orthology
more info
 PubMed 
is_active_in nucleolus IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleolus IDA
Inferred from Direct Assay
more info
 PubMed 
located_in nucleolus ISO
Inferred from Sequence Orthology
more info
 PubMed 
is_active_in nucleoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
 PubMed 
located_in nucleus ISO
Inferred from Sequence Orthology
more info
 PubMed 
part_of protein-containing complex ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
interferon-activable protein 204
Names
ifi-204
interferon, gamma-inducible gene 204
interferon, gamma-inducible protein 16
interferon-inducible protein p204

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_008329.2 → NP_032355.2  interferon-activable protein 204

    Status: VALIDATED

    Source sequence(s)
    AC117682, AC119230, AK150522, BE686930, BU694586, CT010351
    Consensus CDS
    CCDS35792.1
    UniProtKB/Swiss-Prot
    B7ZNS3, P0DOV2, P15092, Q08619, Q3TM07, Q3U776, Q3U7F4, Q3U7K5, Q3UCH9, Q8C4X3, Q921V9
    UniProtKB/TrEMBL
    A0A1Z3MI45
    Related
    ENSMUSP00000106845.3, ENSMUST00000111214.4
    Conserved Domains (2) summary
    cd08305
    Location:10 → 83
    Pyrin; Pyrin: a protein-protein interaction domain
    pfam02760
    Location:225 → 393
    HIN; HIN-200/IF120x domain

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000067.7 Reference GRCm39 C57BL/6J

    Range
    173574859..173594606 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006496675.4 → XP_006496738.1  interferon-activable protein 204 isoform X1

    UniProtKB/TrEMBL
    A0A1Z3MI45
    Conserved Domains (2) summary
    cd08305
    Location:10 → 83
    Pyrin; a protein-protein interaction domain
    pfam02760
    Location:223 → 391
    HIN; HIN-200/IF120x domain
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P0DOV2.1 GenPept UniProtKB/Swiss-Prot:P0DOV2

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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