Il2 interleukin 2 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Il2provided by MGI
Official Full Name: interleukin 2provided by MGI
Primary source: MGI:MGI:96548
See related: Ensembl:ENSMUSG00000027720 AllianceGenome:MGI:96548
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Il-2
Summary: Enables cytokine activity and interleukin-2 receptor binding activity. Involved in negative regulation of T-helper 17 cell differentiation. Acts upstream of or within several processes, including extrinsic apoptotic signaling pathway in absence of ligand; positive regulation of macromolecule metabolic process; and regulation of lymphocyte activation. Located in extracellular space. Is expressed in liver; omental bursa; thymus; and thymus primordium. Used to study Sjogren's syndrome and inflammatory bowel disease. Human ortholog(s) of this gene implicated in several diseases, including Takayasu's arteritis; auditory system disease (multiple); autoimmune disease (multiple); carcinoma (multiple); and neurodegenerative disease (multiple). Orthologous to human IL2 (interleukin 2). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Low expression observed in reference dataset See more
Orthologs: human all
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Genomic context

Location:: 3 B; 3 18.3 cM

Exon count:: 4

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	3	NC_000069.7 (37174862..37180103, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	3	NC_000069.6 (37120713..37125954, complement)

Chromosome 3 - NC_000069.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Spatial microniches of IL-2 combine with IL-10 to drive lung migratory TH2 cells in response to inhaled allergen.
Title: Spatial microniches of IL-2 combine with IL-10 to drive lung migratory T(H)2 cells in response to inhaled allergen.
Tyrosine phosphorylation of both STAT5A and STAT5B is necessary for maximal IL-2 signaling and T cell proliferation.
Title: Tyrosine phosphorylation of both STAT5A and STAT5B is necessary for maximal IL-2 signaling and T cell proliferation.
Long-lasting mRNA-encoded interleukin-2 restores CD8[+] T cell neoantigen immunity in MHC class I-deficient cancers.
Title: Long-lasting mRNA-encoded interleukin-2 restores CD8(+) T cell neoantigen immunity in MHC class I-deficient cancers.
PD-1 Limits IL-2 Production and Thymic Regulatory T Cell Development.
Title: PD-1 Limits IL-2 Production and Thymic Regulatory T Cell Development.
Tumor-infiltrating mast cells stimulate ICOS[+] regulatory T cells through an IL-33 and IL-2 axis to promote gastric cancer progression.
Title: Tumor-infiltrating mast cells stimulate ICOS(+) regulatory T cells through an IL-33 and IL-2 axis to promote gastric cancer progression.
Regulatory T cells use heparanase to access IL-2 bound to extracellular matrix in inflamed tissue.
Title: Regulatory T cells use heparanase to access IL-2 bound to extracellular matrix in inflamed tissue.
Insulin-like Growth Factor-1 Synergizes with IL-2 to Induce Homeostatic Proliferation of Regulatory T Cells.
Title: Insulin-like Growth Factor-1 Synergizes with IL-2 to Induce Homeostatic Proliferation of Regulatory T Cells.
Stimulation of ectopically expressed muscarinic receptors induces IFN-gamma but suppresses IL-2 production by inhibiting activation of pAKT pathways in primary T cells.
Title: Stimulation of ectopically expressed muscarinic receptors induces IFN-γ but suppresses IL-2 production by inhibiting activation of pAKT pathways in primary T cells.
Optimal generation of hepatic tissue-resident memory CD4 T cells requires IL-1 and IL-2.
Title: Optimal generation of hepatic tissue-resident memory CD4 T cells requires IL-1 and IL-2.
Regulatory T cells suppress the formation of potent KLRK1 and IL-7R expressing effector CD8 T cells by limiting IL-2.
Title: Regulatory T cells suppress the formation of potent KLRK1 and IL-7R expressing effector CD8 T cells by limiting IL-2.

Submit: New GeneRIF Correction See all GeneRIFs (359)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (8)
Spontaneous (1) 1 citation
Targeted (13) 1 citation
Transgenic (1) 1 citation

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

NoName (e-PCR)
- UniSTS:492547

D3Mit21 (e-PCR), detects polymorphism
- UniSTS:129631

PMC310860P1 (e-PCR)
- UniSTS:272783

Il2 (e-PCR), detects polymorphism
- UniSTS:143550

Il2 (e-PCR), detects polymorphism
- UniSTS:143551

Il2 (e-PCR), detects polymorphism
- UniSTS:143552

Il2 (e-PCR), detects polymorphism
- UniSTS:143553

Il2 (e-PCR), detects polymorphism
- UniSTS:143554

Il2 (e-PCR), detects polymorphism
- UniSTS:143555

UniSTS:143556 (e-PCR)
- UniSTS:143556

Il2 (e-PCR), detects polymorphism
- UniSTS:143556

Il2 (e-PCR), detects polymorphism
- UniSTS:143557

Il2 (e-PCR), detects polymorphism
- UniSTS:143558

Ntan1 (e-PCR), detects polymorphism
- UniSTS:144070

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables carbohydrate binding	ISO Inferred from Sequence Orthology more info
enables cytokine activity	IDA Inferred from Direct Assay more info	PubMed
enables cytokine activity	IMP Inferred from Mutant Phenotype more info	PubMed
enables cytokine activity	ISO Inferred from Sequence Orthology more info
enables glycosphingolipid binding	ISO Inferred from Sequence Orthology more info
enables growth factor activity	IEA Inferred from Electronic Annotation more info
enables interleukin-2 receptor binding	IDA Inferred from Direct Assay more info	PubMed
enables interleukin-2 receptor binding	ISO Inferred from Sequence Orthology more info
enables kappa-type opioid receptor binding	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in G protein-coupled receptor signaling pathway	ISO Inferred from Sequence Orthology more info
acts_upstream_of T cell proliferation	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of activated T cell proliferation	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of activated T cell proliferation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in adaptive immune response	IEA Inferred from Electronic Annotation more info
involved_in cell surface receptor signaling pathway via STAT	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within cellular response to biotic stimulus	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within extrinsic apoptotic signaling pathway in absence of ligand	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within gene expression	IDA Inferred from Direct Assay more info	PubMed
involved_in interleukin-2-mediated signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in interleukin-2-mediated signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in leukocyte activation involved in immune response	IEA Inferred from Electronic Annotation more info
involved_in leukocyte activation involved in immune response	ISO Inferred from Sequence Orthology more info
acts_upstream_of lymphocyte proliferation	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within negative regulation of B cell apoptotic process	ISO Inferred from Sequence Orthology more info	PubMed
involved_in negative regulation of T-helper 17 cell differentiation	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within negative regulation of inflammatory response	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within negative regulation of lymphocyte proliferation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of protein phosphorylation	ISO Inferred from Sequence Orthology more info
involved_in phospholipase C-activating G protein-coupled receptor signaling pathway	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within positive regulation of B cell proliferation	ISO Inferred from Sequence Orthology more info	PubMed
involved_in positive regulation of T cell differentiation	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within positive regulation of T cell proliferation	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within positive regulation of T cell proliferation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of T cell proliferation	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within positive regulation of activated T cell proliferation	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within positive regulation of activated T cell proliferation	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within positive regulation of activated T cell proliferation	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of cytosolic calcium ion concentration	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of dendritic spine development	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within positive regulation of immunoglobulin production	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of positive regulation of immunoglobulin production	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of interleukin-17 production	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of interleukin-17 production	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within positive regulation of isotype switching to IgG isotypes	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of plasma cell differentiation	IEA Inferred from Electronic Annotation more info
acts_upstream_of positive regulation of plasma cell differentiation	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of protein phosphorylation	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of regulatory T cell differentiation	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within positive regulation of transcription by RNA polymerase II	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within positive regulation of type II interferon production	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within positive regulation of tyrosine phosphorylation of STAT protein	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of tyrosine phosphorylation of STAT protein	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within regulation of CD4-positive, alpha-beta T cell proliferation	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within regulation of T cell homeostatic proliferation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in response to ethanol	ISO Inferred from Sequence Orthology more info
acts_upstream_of transcription by RNA polymerase II	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of tyrosine phosphorylation of STAT protein	IDA Inferred from Direct Assay more info	PubMed

Component	Evidence Code	Pubs
located_in extracellular space	IDA Inferred from Direct Assay more info	PubMed
is_active_in extracellular space	ISO Inferred from Sequence Orthology more info
located_in extracellular space	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: interleukin-2

Names: T-cell growth factor; TCGF

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.