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Lrig1 leucine-rich repeats and immunoglobulin-like domains 1 [ Mus musculus (house mouse) ]

Gene ID: 16206, updated on 24-Dec-2024

Summary

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Official Symbol
Lrig1provided by MGI
Official Full Name
leucine-rich repeats and immunoglobulin-like domains 1provided by MGI
Primary source
MGI:MGI:107935
See related
Ensembl:ENSMUSG00000030029 AllianceGenome:MGI:107935
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Img; LIG-1; D6Bwg0781e
Summary
Acts upstream of or within several processes, including innervation; otolith morphogenesis; and sensory perception of sound. Predicted to be located in plasma membrane. Predicted to be active in extracellular matrix and extracellular space. Is expressed in several structures, including alimentary system; central nervous system; heart; integumental system; and sensory organ. Orthologous to human LRIG1 (leucine rich repeats and immunoglobulin like domains 1). [provided by Alliance of Genome Resources, Dec 2024]
Expression
Ubiquitous expression in colon adult (RPKM 30.2), cerebellum adult (RPKM 20.8) and 26 other tissues See more
Orthologs
human all
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Genomic context

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See Lrig1 in Genome Data Viewer
Location:
6 D2; 6 43.15 cM
Exon count:
25
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 6 NC_000072.7 (94581510..94677205, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 6 NC_000072.6 (94604529..94700298, complement)

Chromosome 6 - NC_000072.7Genomic Context describing neighboring genes Neighboring gene ubiquitin-conjugating enzyme E2 variant 1 pseudogene Neighboring gene STARR-seq mESC enhancer starr_16710 Neighboring gene solute carrier family 25 (mitochondrial carrier, phosphate carrier), member 26 Neighboring gene proteasome (prosome, macropain) subunit, alpha type 3 pseudogene Neighboring gene STARR-seq mESC enhancer starr_16711 Neighboring gene microRNA 7041 Neighboring gene CapStarr-seq enhancer MGSCv37_chr6:94587371-94587480 Neighboring gene VISTA enhancer mm1736 Neighboring gene STARR-seq mESC enhancer starr_16724 Neighboring gene VISTA enhancer mm878 Neighboring gene prefoldin 4 pseudogene Neighboring gene STARR-seq mESC enhancer starr_16726 Neighboring gene STARR-seq mESC enhancer starr_16728 Neighboring gene glyceraldehyde-3-phosphate dehydrogenase pseudogene

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. LRIG1 is a triple threat: ERBB negative regulator, intestinal stem cell marker and tumour suppressor. Wang Y, et al. Br J Cancer, 2013 May 14. PMID 23558895, Free PMC Article
  2. Lrig1 is a haploinsufficient tumor suppressor gene in malignant glioma. Mao F, et al. Oncogenesis, 2018 Feb 2. PMID 29391393, Free PMC Article
  3. LRIG1 expression during homeostasis and skin wound healing in mice. Murad S, et al. J Biol Regul Homeost Agents, 2015 Oct-Dec. PMID 26753643
  4. Lrig1- and Wnt-dependent niches dictate segregation of resident immune cells and melanocytes in murine tail epidermis. Baess SC, et al. Development, 2022 Jul 15. PMID 35815643, Free PMC Article
  5. Epidermal overexpression of LRIG1 disturbs development and homeostasis in skin by disrupting the ERBB system. Hoesl C, et al. J Dermatol Sci, 2019 Dec. PMID 31796338

See all (127) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Lrig1 regulates cell fate specification of glutamatergic neurons via FGF-driven Jak2/Stat3 signaling in cortical progenitors.
    Title: Lrig1 regulates cell fate specification of glutamatergic neurons via FGF-driven Jak2/Stat3 signaling in cortical progenitors.
  2. LRIG1 engages ligand VISTA and impairs tumor-specific CD8[+] T cell responses.
    Title: LRIG1 engages ligand VISTA and impairs tumor-specific CD8(+) T cell responses.
  3. Lrig1 drives cryptogenesis and restrains proliferation during colon development.
    Title: Lrig1 drives cryptogenesis and restrains proliferation during colon development.
  4. Lrig1-expression confers suppressive function to CD4[+] cells and is essential for averting autoimmunity via the Smad2/3/Foxp3 axis.
    Title: Lrig1-expression confers suppressive function to CD4(+) cells and is essential for averting autoimmunity via the Smad2/3/Foxp3 axis.
  5. Lrig1 expression identifies quiescent stem cells in the ventricular-subventricular zone from postnatal development to adulthood and limits their persistent hyperproliferation.
    Title: Lrig1 expression identifies quiescent stem cells in the ventricular-subventricular zone from postnatal development to adulthood and limits their persistent hyperproliferation.
  6. Lrig1- and Wnt-dependent niches dictate segregation of resident immune cells and melanocytes in murine tail epidermis.
    Title: Lrig1- and Wnt-dependent niches dictate segregation of resident immune cells and melanocytes in murine tail epidermis.
  7. Cell-Autonomous Role of EGFR in Spontaneous Duodenal Tumors in LRIG1 Null Mice.
    Title: Cell-Autonomous Role of EGFR in Spontaneous Duodenal Tumors in LRIG1 Null Mice.
  8. Lrig1 and Lrig3 cooperate to control Ret receptor signaling, sensory axonal growth and epidermal innervation.
    Title: Lrig1 and Lrig3 cooperate to control Ret receptor signaling, sensory axonal growth and epidermal innervation.
  9. LRIG1-Mediated Inhibition of EGF Receptor Signaling Regulates Neural Precursor Cell Proliferation in the Neocortex.
    Title: LRIG1-Mediated Inhibition of EGF Receptor Signaling Regulates Neural Precursor Cell Proliferation in the Neocortex.
  10. Lrig1 expression prospectively identifies stem cells in the ventricular-subventricular zone that are neurogenic throughout adult life.
    Title: Lrig1 expression prospectively identifies stem cells in the ventricular-subventricular zone that are neurogenic throughout adult life.
Submit: New GeneRIF Correction See all GeneRIFs (32)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Chemically induced (ENU) (1) 
  • Endonuclease-mediated (2) 
  • Gene trapped (1)  1 citation
  • Targeted (10)  1 citation

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Process Evidence Code Pubs
acts_upstream_of_or_within hair cycle process IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within innervation IGI
Inferred from Genetic Interaction
more info
 PubMed 
acts_upstream_of_or_within otolith morphogenesis IGI
Inferred from Genetic Interaction
more info
 PubMed 
acts_upstream_of_or_within sensory perception of sound IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
is_active_in extracellular matrix IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in extracellular space IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in plasma membrane IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
leucine-rich repeats and immunoglobulin-like domains protein 1
Names
integral membrane glycoprotein

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001355269.2 → NP_001342198.1  leucine-rich repeats and immunoglobulin-like domains protein 1 isoform 2 precursor

    Status: VALIDATED

    Source sequence(s)
    AC122272, AC155330
    UniProtKB/TrEMBL
    B7ZP45
    Conserved Domains (7) summary
    cd05763
    Location:618 → 692
    Ig_1; Subgroup of the immunoglobulin (Ig) superfamily
    smart00082
    Location:444 → 492
    LRRCT; Leucine rich repeat C-terminal domain
    COG4886
    Location:78 → 330
    LRR; Leucine-rich repeat (LRR) protein [Transcription]
    pfam07679
    Location:695 → 782
    I-set; Immunoglobulin I-set domain
    sd00033
    Location:143 → 166
    LRR_RI; leucine-rich repeat [structural motif]
    pfam13855
    Location:385 → 441
    LRR_8; Leucine rich repeat
    pfam13927
    Location:496 → 583
    Ig_3; Immunoglobulin domain

  2. NM_001410069.1 → NP_001396998.1  leucine-rich repeats and immunoglobulin-like domains protein 1 isoform 3

    Status: VALIDATED

    Source sequence(s)
    AC122272, AC155330

  3. NM_001410070.1 → NP_001396999.1  leucine-rich repeats and immunoglobulin-like domains protein 1 isoform 3

    Status: VALIDATED

    Source sequence(s)
    AC122272, AC155330

  4. NM_008377.3 → NP_032403.2  leucine-rich repeats and immunoglobulin-like domains protein 1 isoform 1 precursor

    See identical proteins and their annotated locations for NP_032403.2

    Status: VALIDATED

    Source sequence(s)
    AC122272, AC155330
    Consensus CDS
    CCDS20380.1
    UniProtKB/Swiss-Prot
    E9QL89, P70193
    UniProtKB/TrEMBL
    B7ZP45
    Related
    ENSMUSP00000098686.3, ENSMUST00000101126.3
    Conserved Domains (8) summary
    cd05763
    Location:618 → 692
    Ig_1; Subgroup of the immunoglobulin (Ig) superfamily
    smart00408
    Location:709 → 772
    IGc2; Immunoglobulin C-2 Type
    smart00082
    Location:444 → 492
    LRRCT; Leucine rich repeat C-terminal domain
    cd00116
    Location:57 → 325
    LRR_RI; Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond ...
    pfam07679
    Location:601 → 691
    I-set; Immunoglobulin I-set domain
    sd00033
    Location:143 → 166
    LRR_RI; leucine-rich repeat [structural motif]
    pfam13855
    Location:213 → 273
    LRR_8; Leucine rich repeat
    pfam13927
    Location:496 → 583
    Ig_3; Immunoglobulin domain

RNA

  1. NR_176936.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC122272, AC155330

  2. NR_176937.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC122272, AC155330

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000072.7 Reference GRCm39 C57BL/6J

    Range
    94581510..94677205 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_030255196.2 → XP_030111056.1  leucine-rich repeats and immunoglobulin-like domains protein 1 isoform X2

    Conserved Domains (6) summary
    cd05763
    Location:356 → 430
    Ig_1; Subgroup of the immunoglobulin (Ig) superfamily
    smart00082
    Location:182 → 230
    LRRCT; Leucine rich repeat C-terminal domain
    sd00033
    Location:3 → 24
    LRR_RI; leucine-rich repeat [structural motif]
    pfam13855
    Location:123 → 179
    LRR_8; Leucine rich repeat
    pfam07679
    Location:433 → 520
    I-set; Immunoglobulin I-set domain
    cl11960
    Location:235 → 335
    Ig; Immunoglobulin domain

  2. XM_030255198.1 → XP_030111058.1  leucine-rich repeats and immunoglobulin-like domains protein 1 isoform X2

    Conserved Domains (6) summary
    cd05763
    Location:356 → 430
    Ig_1; Subgroup of the immunoglobulin (Ig) superfamily
    smart00082
    Location:182 → 230
    LRRCT; Leucine rich repeat C-terminal domain
    sd00033
    Location:3 → 24
    LRR_RI; leucine-rich repeat [structural motif]
    pfam13855
    Location:123 → 179
    LRR_8; Leucine rich repeat
    pfam07679
    Location:433 → 520
    I-set; Immunoglobulin I-set domain
    cl11960
    Location:235 → 335
    Ig; Immunoglobulin domain

  3. XM_036165882.1 → XP_036021775.1  leucine-rich repeats and immunoglobulin-like domains protein 1 isoform X1

    UniProtKB/TrEMBL
    B7ZP45
    Conserved Domains (7) summary
    smart00082
    Location:339 → 387
    LRRCT; Leucine rich repeat C-terminal domain
    sd00033
    Location:38 → 61
    LRR_RI; leucine-rich repeat [structural motif]
    pfam07679
    Location:590 → 677
    I-set; Immunoglobulin I-set domain
    pfam13927
    Location:391 → 478
    Ig_3; Immunoglobulin domain
    cd00096
    Location:598 → 601
    Ig; Ig strand A' [structural motif]
    cd05763
    Location:497 → 587
    IgI_LRIG1-like; Immunoglobulin (Ig)-like ectodomain of the LRIG1 (Leucine-rich Repeats And Immunoglobulin-like Domains Protein 1) and similar proteins; member of the I-set of IgSF domains
    cd21340
    Location:20 → 220
    PPP1R42; protein phosphatase 1 regulatory subunit 42

  4. XM_030255197.1 → XP_030111057.1  leucine-rich repeats and immunoglobulin-like domains protein 1 isoform X2

    Conserved Domains (6) summary
    cd05763
    Location:356 → 430
    Ig_1; Subgroup of the immunoglobulin (Ig) superfamily
    smart00082
    Location:182 → 230
    LRRCT; Leucine rich repeat C-terminal domain
    sd00033
    Location:3 → 24
    LRR_RI; leucine-rich repeat [structural motif]
    pfam13855
    Location:123 → 179
    LRR_8; Leucine rich repeat
    pfam07679
    Location:433 → 520
    I-set; Immunoglobulin I-set domain
    cl11960
    Location:235 → 335
    Ig; Immunoglobulin domain
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P70193.2 GenPept UniProtKB/Swiss-Prot:P70193

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