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Kcnk7 potassium channel, subfamily K, member 7 [ Mus musculus (house mouse) ]

Gene ID: 16530, updated on 9-Aug-2024

Summary

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Official Symbol
Kcnk7provided by MGI
Official Full Name
potassium channel, subfamily K, member 7provided by MGI
Primary source
MGI:MGI:1341841
See related
Ensembl:ENSMUSG00000024936 AllianceGenome:MGI:1341841
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Knot; Mlk3; Kcnk6; Kcnk8; 2310014G03Rik
Summary
Predicted to enable potassium ion leak channel activity. Predicted to be involved in potassium ion transmembrane transport and stabilization of membrane potential. Predicted to act upstream of or within potassium ion transport and regulation of ion transmembrane transport. Predicted to be located in membrane. Predicted to be integral component of membrane. Predicted to be integral component of plasma membrane. Is expressed in several structures, including alimentary system; eye; genitourinary system; heart; and thymus. Orthologous to human KCNK7 (potassium two pore domain channel subfamily K member 7). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in stomach adult (RPKM 3.0), testis adult (RPKM 2.9) and 10 other tissues See more
Orthologs
human all
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Genomic context

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See Kcnk7 in Genome Data Viewer
Location:
19 A; 19 4.34 cM
Exon count:
4
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 19 NC_000085.7 (5754471..5757956)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 19 NC_000085.6 (5704471..5707984)

Chromosome 19 - NC_000085.7Genomic Context describing neighboring genes Neighboring gene pecanex homolog 3 Neighboring gene microRNA 6987 Neighboring gene STARR-positive B cell enhancer ABC_E4259 Neighboring gene STARR-positive B cell enhancer ABC_E11012 Neighboring gene mitogen-activated protein kinase kinase kinase 11 Neighboring gene EH domain binding protein 1-like 1 Neighboring gene family with sequence similarity 89, member B Neighboring gene zinc ribbon domain containing 2

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Knockout of the gene encoding the K(2P) channel KCNK7 does not alter volatile anesthetic sensitivity. Yost CS, et al. Behav Brain Res, 2008 Nov 21. PMID 18572259, Free PMC Article
  2. Genomic organization and chromosomal localization of the murine 2 P domain potassium channel gene Kcnk8: conservation of gene structure in 2 P domain potassium channels. Bockenhauer D, et al. Gene, 2000 Dec 31. PMID 11167025
  3. Cloning of a new mouse two-P domain channel subunit and a human homologue with a unique pore structure. Salinas M, et al. J Biol Chem, 1999 Apr 23. PMID 10206991
  4. Genomic sequencing reveals the structure of the Kcnk6 and map3k11 genes and their close vicinity to the sipa1 gene on mouse chromosome 19. Saridaki A, et al. Cytogenet Cell Genet, 2000. PMID 10894943
  5. Sipa1 is a candidate for underlying the metastasis efficiency modifier locus Mtes1. Park YG, et al. Nat Genet, 2005 Oct. PMID 16142231, Free PMC Article

See all (18) citations in PubMed

GeneRIFs: Gene References Into Functions

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Pathways from PubChem

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General gene information

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Markers

Homology

Clone Names

  • MGC129259

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables outward rectifier potassium channel activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables potassium channel activity ISS
Inferred from Sequence or Structural Similarity
more info
 PubMed 
enables potassium ion leak channel activity IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within monoatomic ion transmembrane transport IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within monoatomic ion transport IEA
Inferred from Electronic Annotation
more info
  
involved_in potassium ion transmembrane transport IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within potassium ion transmembrane transport ISS
Inferred from Sequence or Structural Similarity
more info
 PubMed 
acts_upstream_of_or_within potassium ion transport IEA
Inferred from Electronic Annotation
more info
  
involved_in stabilization of membrane potential IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
part_of monoatomic ion channel complex IEA
Inferred from Electronic Annotation
more info
  
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in plasma membrane ISS
Inferred from Sequence or Structural Similarity
more info
 PubMed 

General protein information

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Preferred Names
potassium channel subfamily K member 7
Names
double-pore K(+) channel 3
neuromuscular two p domain potassium channel
putative potassium channel DP3

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_010609.4 → NP_034739.2  potassium channel subfamily K member 7 precursor

    See identical proteins and their annotated locations for NP_034739.2

    Status: VALIDATED

    Source sequence(s)
    AC134563
    Consensus CDS
    CCDS29477.1
    UniProtKB/TrEMBL
    Q3KNZ8, Q9JJ14
    Related
    ENSMUSP00000051278.4, ENSMUST00000052448.4
    Conserved Domains (1) summary
    pfam07885
    Location:89 → 140
    Ion_trans_2; Ion channel

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000085.7 Reference GRCm39 C57BL/6J

    Range
    5754471..5757956
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006531666.5 → XP_006531729.1  potassium channel subfamily K member 7 isoform X1

    See identical proteins and their annotated locations for XP_006531729.1

    UniProtKB/TrEMBL
    A0A494B9E8
    Related
    ENSMUSP00000157581.2, ENSMUST00000236818.2
    Conserved Domains (1) summary
    pfam07885
    Location:88 → 115
    Ion_trans_2; Ion channel

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_001004138.1: Suppressed sequence

    Description
    NM_001004138.1: This RefSeq was permanently suppressed because it represents a poorly supported variant with non-consensus splice sites.
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9Z2T1.3 GenPept UniProtKB/Swiss-Prot:Q9Z2T1

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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