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Kcnmb1 potassium large conductance calcium-activated channel, subfamily M, beta member 1 [ Mus musculus (house mouse) ]

Gene ID: 16533, updated on 9-Dec-2024

Summary

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Official Symbol
Kcnmb1provided by MGI
Official Full Name
potassium large conductance calcium-activated channel, subfamily M, beta member 1provided by MGI
Primary source
MGI:MGI:1334203
See related
Ensembl:ENSMUSG00000020155 AllianceGenome:MGI:1334203
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
BKbeta1
Summary
Enables calcium-activated potassium channel activity. Predicted to be involved in several processes, including cellular response to bile acid; cellular response to ethanol; and detection of calcium ion. Located in membrane. Part of voltage-gated potassium channel complex. Is expressed in arterial system; sensory organ; skeleton; and tarsus. Human ortholog(s) of this gene implicated in hypertension. Orthologous to human KCNMB1 (potassium calcium-activated channel subfamily M regulatory beta subunit 1). [provided by Alliance of Genome Resources, Dec 2024]
Expression
Biased expression in bladder adult (RPKM 14.4), ovary adult (RPKM 3.3) and 9 other tissues See more
Orthologs
human all
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Genomic context

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See Kcnmb1 in Genome Data Viewer
Location:
11 A4; 11 19.32 cM
Exon count:
5
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 11 NC_000077.7 (33912955..33923641)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 11 NC_000077.6 (33962955..33973641)

Chromosome 11 - NC_000077.7Genomic Context describing neighboring genes Neighboring gene Kv channel-interacting protein 1 Neighboring gene CapStarr-seq enhancer MGSCv37_chr11:33819926-33820148 Neighboring gene predicted gene, 39677 Neighboring gene STARR-positive B cell enhancer ABC_E8390 Neighboring gene CapStarr-seq enhancer MGSCv37_chr11:33838922-33839284 Neighboring gene predicted gene, 36395 Neighboring gene RIKEN cDNA 4930469K13 gene Neighboring gene predicted gene, 51857 Neighboring gene predicted gene, 53680

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Renal fluid and electrolyte handling in BKCa-beta1-/- mice. Pluznick JL, et al. Am J Physiol Renal Physiol, 2003 Jun. PMID 12620927
  2. Dual effect of tamoxifen on arterial KCa channels does not depend on the presence of the beta1 subunit. Pérez GJ. J Biol Chem, 2005 Jun 10. PMID 15826942
  3. Smooth muscle cholesterol enables BK β1 subunit-mediated channel inhibition and subsequent vasoconstriction evoked by alcohol. Bukiya AN, et al. Arterioscler Thromb Vasc Biol, 2011 Nov. PMID 21868700, Free PMC Article
  4. Large-conductance Ca2+-activated K+ channel beta1-subunit knockout mice are not hypertensive. Xu H, et al. Am J Physiol Heart Circ Physiol, 2011 Feb. PMID 21131476, Free PMC Article
  5. Vascular BK channel deficiency exacerbates organ damage and mortality in endotoxemic mice. Xu H, et al. J Cardiovasc Pharmacol, 2012 Mar. PMID 21997262, Free PMC Article

See all (72) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Interspecies and regional variability of alcohol action on large cerebral arteries: regulation by KCNMB1 proteins.
    Title: Interspecies and regional variability of alcohol action on large cerebral arteries: regulation by KCNMB1 proteins.
  2. Knockout of AKAP150 improves impaired BK channel-mediated vascular dysfunction through the Akt/GSK3beta signalling pathway in diabetes mellitus.
    Title: Knockout of AKAP150 improves impaired BK channel-mediated vascular dysfunction through the Akt/GSK3β signalling pathway in diabetes mellitus.
  3. Compromised PASMC beta1 function may contribute to the heightened microvascular vasoconstriction that characterizes pulmonary hypertension.
    Title: β1-Subunit of the calcium-sensitive potassium channel modulates the pulmonary vascular smooth muscle cell response to hypoxia.
  4. Whole-cell currents density of BK channels and amplitude of spontaneous transient outward currents were significantly reduced in hypoxia vascular myocytes.
    Title: Chronic Prenatal Hypoxia Down-Regulated BK Channel Β1 Subunits in Mesenteric Artery Smooth Muscle Cells of the Offspring.
  5. Study showed that in human and rat arterial myocytes, membrane depolarization rapidly increased the cell surface abundance of auxiliary BK beta1 subunits but not that of the pore-forming BKalpha channels. Membrane depolarization stimulated voltage-dependent Ca(2+) channels, leading to Ca(2+) influx and the activation of Rho kinase (ROCK) 1 and 2.
    Title: Membrane depolarization activates BK channels through ROCK-mediated β1 subunit surface trafficking to limit vasoconstriction.
  6. Expression of vascular large-conductance calcium-activated potassium channel Kcnmb1 is regulated by Nrf2 signaling.
    Title: Regulation of vascular large-conductance calcium-activated potassium channels by Nrf2 signalling.
  7. 7-Ketocholesterol induces the reduction of KCNMB1 through the AhR pathway.
    Title: 7-Ketocholesterol induces the reduction of KCNMB1 in atherosclerotic blood vessels.
  8. BK channel activity directly affects vascular tone but influences blood pressure independent of this effect via different pathways
    Title: Smooth muscle BK channel activity influences blood pressure independent of vascular tone in mice.
  9. up-regulation of NF-kappaB-dependent MuRF1 expression is a novel mechanism that leads to BK channelopathy and vasculopathy in diabetes
    Title: Regulation of large conductance Ca2+-activated K+ (BK) channel β1 subunit expression by muscle RING finger protein 1 in diabetic vessels.
  10. Our results support a model whereby subcellular anchoring of CaN by AKAP150 is a key molecular determinant of vascular BKCa channel remodeling, which contributes to vasoconstriction during diabetes mellitus.
    Title: AKAP150 contributes to enhanced vascular tone by facilitating large-conductance Ca2+-activated K+ channel remodeling in hyperglycemia and diabetes mellitus.
Submit: New GeneRIF Correction See all GeneRIFs (34)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (5) 
  • Targeted (3)  1 citation

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables calcium-activated potassium channel activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables calcium-activated potassium channel activity IGI
Inferred from Genetic Interaction
more info
 PubMed 
enables potassium channel regulator activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables potassium channel regulator activity ISO
Inferred from Sequence Orthology
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in cellular response to bile acid ISO
Inferred from Sequence Orthology
more info
  
involved_in cellular response to ethanol ISO
Inferred from Sequence Orthology
more info
  
involved_in detection of calcium ion IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in positive regulation of potassium ion transmembrane transport ISO
Inferred from Sequence Orthology
more info
  
involved_in potassium ion transmembrane transport IEA
Inferred from Electronic Annotation
more info
  
involved_in response to calcium ion ISO
Inferred from Sequence Orthology
more info
  
involved_in vasodilation ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
located_in membrane IDA
Inferred from Direct Assay
more info
 PubMed 
located_in plasma membrane TAS
Traceable Author Statement
more info
  
part_of voltage-gated potassium channel complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of voltage-gated potassium channel complex IGI
Inferred from Genetic Interaction
more info
 PubMed 

General protein information

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Preferred Names
calcium-activated potassium channel subunit beta-1
Names
BK channel beta subunit
BK channel subunit beta-1
BKbeta
calcium-activated potassium channel subunit beta
calcium-activated potassium channel, subfamily M subunit beta-1
charybdotoxin receptor subunit beta-1
k(VCA)beta-1
maxi K channel subunit beta-1
slo-beta
slo-beta-1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_031169.4 → NP_112446.2  calcium-activated potassium channel subunit beta-1

    See identical proteins and their annotated locations for NP_112446.2

    Status: VALIDATED

    Source sequence(s)
    AF020711, AK038987, AK039715, AL731867, AU043056, BB196456
    Consensus CDS
    CCDS24538.1
    UniProtKB/TrEMBL
    Q5SQK1
    Related
    ENSMUSP00000020362.3, ENSMUST00000020362.3
    Conserved Domains (1) summary
    pfam03185
    Location:7 → 190
    CaKB; Calcium-activated potassium channel, beta subunit

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000077.7 Reference GRCm39 C57BL/6J

    Range
    33912955..33923641
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006514541.4 → XP_006514604.1  calcium-activated potassium channel subunit beta-1 isoform X1

    See identical proteins and their annotated locations for XP_006514604.1

    UniProtKB/TrEMBL
    Q5SQK1
    Conserved Domains (1) summary
    pfam03185
    Location:7 → 190
    CaKB; Calcium-activated potassium channel, beta subunit
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q8CAE3.3 GenPept UniProtKB/Swiss-Prot:Q8CAE3

Gene LinkOut

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