Kcns1 K+ voltage-gated channel, subfamily S, 1 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Kcns1provided by MGI
Official Full Name: K+ voltage-gated channel, subfamily S, 1provided by MGI
Primary source: MGI:MGI:1197019
See related: Ensembl:ENSMUSG00000040164 AllianceGenome:MGI:1197019
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Kv9.1
Summary: Enables potassium channel regulator activity. Involved in potassium ion transport and regulation of potassium ion transmembrane transport. Located in perinuclear region of cytoplasm and plasma membrane. Part of voltage-gated potassium channel complex. Orthologous to human KCNS1 (potassium voltage-gated channel modifier subfamily S member 1). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Biased expression in cortex adult (RPKM 4.4), limb E14.5 (RPKM 3.1) and 8 other tissues See more
Orthologs: human all
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Genomic context

Location:: 2 H3; 2 84.6 cM

Exon count:: 5

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	2	NC_000068.8 (164005539..164013865, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	2	NC_000068.7 (164163619..164171113, complement)

Chromosome 2 - NC_000068.8 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

After neuropathic injury, Kcns1 KO mice exhibited exaggerated mechanical pain responses and hypersensitivity to both noxious and innocuous cold, consistent with increased A-fiber activity. Interestingly, Kcns1 deletion also improved locomotor performance in the rotarod test, indicative of augmented proprioceptive signalling.
Title: Mice lacking Kcns1 in peripheral neurons show increased basal and neuropathic pain sensitivity.

Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (3)
Targeted (2) 1 citation

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables delayed rectifier potassium channel activity	ISO Inferred from Sequence Orthology more info
enables potassium channel regulator activity	IBA Inferred from Biological aspect of Ancestor more info
enables potassium channel regulator activity	IDA Inferred from Direct Assay more info	PubMed
enables potassium channel regulator activity	ISO Inferred from Sequence Orthology more info
enables potassium channel regulator activity	ISS Inferred from Sequence or Structural Similarity more info
enables voltage-gated potassium channel activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in action potential	IBA Inferred from Biological aspect of Ancestor more info
involved_in potassium ion transmembrane transport	IBA Inferred from Biological aspect of Ancestor more info
involved_in potassium ion transmembrane transport	IEA Inferred from Electronic Annotation more info
involved_in potassium ion transport	IDA Inferred from Direct Assay more info	PubMed
involved_in protein homooligomerization	IEA Inferred from Electronic Annotation more info
involved_in regulation of potassium ion transmembrane transport	IDA Inferred from Direct Assay more info	PubMed

Component	Evidence Code	Pubs
is_active_in membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in perinuclear region of cytoplasm	IDA Inferred from Direct Assay more info	PubMed
located_in plasma membrane	IDA Inferred from Direct Assay more info	PubMed
located_in plasma membrane	ISO Inferred from Sequence Orthology more info
located_in plasma membrane	ISS Inferred from Sequence or Structural Similarity more info
part_of voltage-gated potassium channel complex	IBA Inferred from Biological aspect of Ancestor more info
part_of voltage-gated potassium channel complex	IDA Inferred from Direct Assay more info	PubMed
part_of voltage-gated potassium channel complex	ISO Inferred from Sequence Orthology more info
part_of voltage-gated potassium channel complex	ISS Inferred from Sequence or Structural Similarity more info

General protein information

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Preferred Names: delayed-rectifier potassium channel regulatory subunit KCNS1; potassium voltage-gated channel subfamily S member 1

Names: delayed-rectifier K(+) channel alpha subunit 1; delayed-rectifier potassium channel subunit Kv9.1; potassium voltage-gated channel modifier subfamily S member 1; voltage-gated potassium channel subunit Kv9.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_008435.2 → NP_032461.2 delayed-rectifier potassium channel regulatory subunit KCNS1

See identical proteins and their annotated locations for NP_032461.2

Status: VALIDATED

Source sequence(s)

AF008573, AK158889, AL591512, AW047812, BY127291

Consensus CDS

CCDS17022.1

UniProtKB/Swiss-Prot

A2A5M1, O35173

UniProtKB/TrEMBL

Q3TY49

Related

ENSMUSP00000038901.4, ENSMUST00000045196.4

Conserved Domains (2) summary

cl38908
Location:21 → 126

BTB_POZ; BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain superfamily

pfam00520
Location:188 → 439

Ion_trans; Ion transport protein

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000068.8 Reference GRCm39 C57BL/6J

Range

164005539..164013865 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_036158792.1 → XP_036014685.1 potassium voltage-gated channel subfamily S member 1 isoform X1

UniProtKB/Swiss-Prot

A2A5M1, O35173

UniProtKB/TrEMBL

Q3TY49

Conserved Domains (2) summary

cl38908
Location:21 → 126

BTB_POZ; BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain superfamily

pfam00520
Location:188 → 439

Ion_trans; Ion transport protein