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Kera keratocan [ Mus musculus (house mouse) ]

Gene ID: 16545, updated on 17-Aug-2024

Summary

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Official Symbol
Keraprovided by MGI
Official Full Name
keratocanprovided by MGI
Primary source
MGI:MGI:1202398
See related
Ensembl:ENSMUSG00000019932 AllianceGenome:MGI:1202398
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
KTN; CNA2; SLRR2B
Summary
Acts upstream of or within cornea development in camera-type eye. Predicted to be located in extracellular region. Predicted to be active in extracellular space. Is expressed in several structures, including central nervous system; cranial muscle; jaw; limb mesenchyme; and sensory organ. Used to study cornea plana. Human ortholog(s) of this gene implicated in arcus senilis; cornea plana; and corneal dystrophy. Orthologous to human KERA (keratocan). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Restricted expression toward limb E14.5 (RPKM 43.4) See more
Orthologs
human all
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Genomic context

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Location:
10 C3; 10 50.34 cM
Exon count:
4
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 10 NC_000076.7 (97442873..97449555)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 10 NC_000076.6 (97606962..97613688)

Chromosome 10 - NC_000076.7Genomic Context describing neighboring genes Neighboring gene RIKEN cDNA 4930473O22 gene Neighboring gene lumican Neighboring gene predicted gene, 40749 Neighboring gene epiphycan Neighboring gene predicted gene 10754

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Keratocan is expressed by osteoblasts and can modulate osteogenic differentiation. Igwe JC, et al. Connect Tissue Res, 2011 Oct. PMID 21405980, Free PMC Article
  2. An X-ray scattering investigation of corneal structure in keratocan-deficient mice. Meek KM, et al. Matrix Biol, 2003 Nov. PMID 14667839
  3. Keratocan-deficient mice display alterations in corneal structure. Liu CY, et al. J Biol Chem, 2003 Jun 13. PMID 12665512
  4. The cloning of mouse keratocan cDNA and genomic DNA and the characterization of its expression during eye development. Liu CY, et al. J Biol Chem, 1998 Aug 28. PMID 9712886
  5. Excess Transforming Growth Factor-α Changed the Cell Properties of Corneal Epithelium and Stroma. Zhang L, et al. Invest Ophthalmol Vis Sci, 2020 Jul 1. PMID 32668000, Free PMC Article

See all (47) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Stromal matrix directs corneal fibroblasts to re-express keratocan after injury and transplantation.
    Title: Stromal matrix directs corneal fibroblasts to re-express keratocan after injury and transplantation.
  2. rare variant in KERA was identified in a large kindred with premature atherosclerosis
    Title: Mutation in KERA identified by linkage analysis and targeted resequencing in a pedigree with premature atherosclerosis.
  3. our results demonstrate the expression of keratocan by osteoblast lineage cells and its ability to modulate osteoblast function.
    Title: Keratocan is expressed by osteoblasts and can modulate osteogenic differentiation.
  4. lumican and keratocan core proteins bind the CXC chemokine KC during a corneal inflammatory response, indicating that corneal KSPGs mediate neutrophil recruitment to the cornea by regulating chemokine gradient formation.
    Title: Keratocan and lumican regulate neutrophil infiltration and corneal clarity in lipopolysaccharide-induced keratitis by direct interaction with CXCL1.
  5. Keratocan-deficient mice have corneal collagen fibrils with significantly larger diameters than those in wild-type mice, and increased centre-to-centre spacing of the fibrils.
    Title: An X-ray scattering investigation of corneal structure in keratocan-deficient mice.
  6. Keratocan plays a unique role in maintaining the appropriate corneal shape to ensure normal vision
    Title: Keratocan-deficient mice display alterations in corneal structure.
  7. lumican has a novel regulatory role in keratocan expression at the transcriptional level
    Title: Keratocan, a cornea-specific keratan sulfate proteoglycan, is regulated by lumican.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (3) 
  • Targeted (2)  1 citation

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Process Evidence Code Pubs
acts_upstream_of_or_within cornea development in camera-type eye IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
located_in extracellular region IEA
Inferred from Electronic Annotation
more info
  
is_active_in extracellular space IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
keratocan
Names
keratan sulfate proteoglycan keratocan

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_008438.3 → NP_032464.1  keratocan precursor

    See identical proteins and their annotated locations for NP_032464.1

    Status: VALIDATED

    Source sequence(s)
    AC159710
    Consensus CDS
    CCDS36044.1
    UniProtKB/Swiss-Prot
    O35367
    UniProtKB/TrEMBL
    A4FUJ3, Q8C3D9
    Related
    ENSMUSP00000100923.3, ENSMUST00000105286.4
    Conserved Domains (3) summary
    PRK15370
    Location:16 → 298
    PRK15370; type III secretion system effector E3 ubiquitin transferase SlrP
    sd00033
    Location:74 → 97
    LRR_RI; leucine-rich repeat [structural motif]
    pfam13855
    Location:268 → 331
    LRR_8; Leucine rich repeat

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000076.7 Reference GRCm39 C57BL/6J

    Range
    97442873..97449555
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006513273.5 → XP_006513336.1  keratocan isoform X1

    See identical proteins and their annotated locations for XP_006513336.1

    UniProtKB/Swiss-Prot
    O35367
    UniProtKB/TrEMBL
    A4FUJ3, Q8C3D9
    Conserved Domains (3) summary
    PRK15370
    Location:16 → 298
    PRK15370; type III secretion system effector E3 ubiquitin transferase SlrP
    sd00033
    Location:74 → 97
    LRR_RI; leucine-rich repeat [structural motif]
    pfam13855
    Location:268 → 331
    LRR_8; Leucine rich repeat
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
O35367.1 GenPept UniProtKB/Swiss-Prot:O35367

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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