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Kif1c kinesin family member 1C [ Mus musculus (house mouse) ]

Gene ID: 16562, updated on 9-Dec-2024

Summary

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Official Symbol
Kif1cprovided by MGI
Official Full Name
kinesin family member 1Cprovided by MGI
Primary source
MGI:MGI:1098260
See related
Ensembl:ENSMUSG00000020821 AllianceGenome:MGI:1098260
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Ltxs1; Orch3; D11Bwg1349e; B430105J22Rik
Summary
Predicted to enable ATP hydrolysis activity; microtubule binding activity; and plus-end-directed microtubule motor activity. Acts upstream of or within retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum. Located in Golgi apparatus. Is expressed in alimentary system; hindbrain meninges; submandibular gland primordium; telencephalon; and vibrissa. Human ortholog(s) of this gene implicated in spastic ataxia 2. Orthologous to human KIF1C (kinesin family member 1C). [provided by Alliance of Genome Resources, Dec 2024]
Expression
Ubiquitous expression in heart adult (RPKM 50.0), colon adult (RPKM 41.5) and 27 other tissues See more
Orthologs
human all
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Genomic context

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See Kif1c in Genome Data Viewer
Location:
11 B3; 11 43.21 cM
Exon count:
24
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 11 NC_000077.7 (70591170..70622796)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 11 NC_000077.6 (70700396..70731970)

Chromosome 11 - NC_000077.7Genomic Context describing neighboring genes Neighboring gene STARR-positive B cell enhancer ABC_E62 Neighboring gene sperm associated antigen 7 Neighboring gene calmodulin binding transcription activator 2 Neighboring gene inhibitor of CDK, cyclin A1 interacting protein 1 Neighboring gene STARR-positive B cell enhancer ABC_E7009 Neighboring gene microRNA 6925 Neighboring gene predicted gene 12320 Neighboring gene 39S ribosomal protein L42, mitochondrial pseudogene

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. M-INK, a novel tool for visualizing melanosomes and melanocores. Ishida M, et al. J Biochem, 2017 Apr 1. PMID 28096452
  2. Identification of Orch3, a locus controlling dominant resistance to autoimmune orchitis, as kinesin family member 1C. del Rio R, et al. PLoS Genet, 2012. PMID 23300462, Free PMC Article
  3. Exclusion of Kif1c as a candidate gene for anthrax toxin susceptibility. Nakajima K, et al. Microb Pathog, 2010 May. PMID 20188815
  4. Kif1C, a kinesin-like motor protein, mediates mouse macrophage resistance to anthrax lethal factor. Watters JW, et al. Curr Biol, 2001 Oct 2. PMID 11591317
  5. Ltx1, a mouse locus that influences the susceptibility of macrophages to cytolysis caused by intoxication with Bacillus anthracis lethal factor, maps to chromosome 11. Roberts JE, et al. Mol Microbiol, 1998 Jul. PMID 9720874

See all (38) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Kif1c regulates osteoclastic bone resorption as a downstream molecule of p130Cas.
    Title: Kif1c regulates osteoclastic bone resorption as a downstream molecule of p130Cas.
  2. Study shows that the microtubule binding surface of Kif1c motor domain interacts with its stalk and that these autoinhibitory interactions are released upon binding of protein tyrosine phosphatase Ptpn21. The FERM domain of Ptpn21 stimulates dense core vesicle transport in primary hippocampal neurons and rescues integrin trafficking in Kif1c-depleted cells.
    Title: PTPN21 and Hook3 relieve KIF1C autoinhibition and activate intracellular transport.
  3. The melanocore-interacting Kif1c-tail (M-INK) probe localize melanosomes in keratinocytes.
    Title: M-INK, a novel tool for visualizing melanosomes and melanocores.
  4. by utilizing a forward genetic approach, we identified kinesin family member 1C (Kif1c) as a positional candidate for Orch3 and, using a transgenic approach, demonstrated that Kif1c is Orch3
    Title: Identification of Orch3, a locus controlling dominant resistance to autoimmune orchitis, as kinesin family member 1C.
  5. Kif1c was excluded as a candidate anthrax susceptibility gene
    Title: Exclusion of Kif1c as a candidate gene for anthrax toxin susceptibility.
  6. More than 90% of early endocytic vesicles associated with Kifc1 also contained Kif5B, and inhibition of Kifc1 with antibody resulted in enhancement of plus-end-directed motility.
    Title: Kif5B and Kifc1 interact and are required for motility and fission of early endocytic vesicles in mouse liver.
Submit: New GeneRIF Correction

Phenotypes

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Associated conditions

Description Tests
autoimmune orchitis resistance 3
GeneReviews: Not available

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • MGC28766

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
  
enables ATP hydrolysis activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables microtubule binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables microtubule binding IEA
Inferred from Electronic Annotation
more info
  
enables microtubule motor activity IEA
Inferred from Electronic Annotation
more info
  
enables plus-end-directed microtubule motor activity IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in anterograde neuronal dense core vesicle transport ISO
Inferred from Sequence Orthology
more info
  
involved_in microtubule-based movement IEA
Inferred from Electronic Annotation
more info
  
involved_in retrograde neuronal dense core vesicle transport IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in retrograde neuronal dense core vesicle transport ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in vesicle-mediated transport IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
located_in Golgi apparatus IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in axon IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in dendrite IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of kinesin complex IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in microtubule IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in microtubule IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
kinesin-like protein KIF1C
Names
N-3 kinsin
kinesin 1C
kinesin superfamily protein 1C
lethal factor toxin susceptibility 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_153103.2 → NP_694743.2  kinesin-like protein KIF1C

    See identical proteins and their annotated locations for NP_694743.2

    Status: VALIDATED

    Source sequence(s)
    AB074017, AK029250, AK046574, AL596117
    Consensus CDS
    CCDS24965.1
    UniProtKB/Swiss-Prot
    O35071, Q5SX62
    UniProtKB/TrEMBL
    Q8VI89
    Related
    ENSMUSP00000092075.5, ENSMUST00000094499.11
    Conserved Domains (3) summary
    cd00060
    Location:499 → 599
    FHA; Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins ...
    cd01365
    Location:4 → 355
    KISc_KIF1A_KIF1B; Kinesin motor domain, KIF1_like proteins
    pfam16183
    Location:352 → 522
    Kinesin_assoc; Kinesin-associated

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000077.7 Reference GRCm39 C57BL/6J

    Range
    70591170..70622796
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_036156353.1 → XP_036012246.1  kinesin-like protein KIF1C isoform X1

    UniProtKB/TrEMBL
    E9Q9B0, Q6A011
    Conserved Domains (3) summary
    cd00060
    Location:499 → 599
    FHA; Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins ...
    cd01365
    Location:4 → 355
    KISc_KIF1A_KIF1B; Kinesin motor domain, KIF1_like proteins
    pfam16183
    Location:352 → 522
    Kinesin_assoc; Kinesin-associated

  2. XM_006532321.5 → XP_006532384.1  kinesin-like protein KIF1C isoform X2

    See identical proteins and their annotated locations for XP_006532384.1

    UniProtKB/Swiss-Prot
    O35071, Q5SX62
    UniProtKB/TrEMBL
    Q8VI89
    Related
    ENSMUSP00000099614.2, ENSMUST00000102554.8
    Conserved Domains (3) summary
    cd00060
    Location:499 → 599
    FHA; Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins ...
    cd01365
    Location:4 → 355
    KISc_KIF1A_KIF1B; Kinesin motor domain, KIF1_like proteins
    pfam16183
    Location:352 → 522
    Kinesin_assoc; Kinesin-associated

  3. XM_036156351.1 → XP_036012244.1  kinesin-like protein KIF1C isoform X1

    UniProtKB/TrEMBL
    E9Q9B0, Q6A011
    Conserved Domains (3) summary
    cd00060
    Location:499 → 599
    FHA; Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins ...
    cd01365
    Location:4 → 355
    KISc_KIF1A_KIF1B; Kinesin motor domain, KIF1_like proteins
    pfam16183
    Location:352 → 522
    Kinesin_assoc; Kinesin-associated

  4. XM_006532323.5 → XP_006532386.1  kinesin-like protein KIF1C isoform X4

    Conserved Domains (2) summary
    cd01365
    Location:4 → 355
    KISc_KIF1A_KIF1B; Kinesin motor domain, KIF1_like proteins
    pfam16183
    Location:352 → 522
    Kinesin_assoc; Kinesin-associated

  5. XM_036156354.1 → XP_036012247.1  kinesin-like protein KIF1C isoform X1

    UniProtKB/TrEMBL
    E9Q9B0, Q6A011
    Related
    ENSMUSP00000072048.6, ENSMUST00000072187.12
    Conserved Domains (3) summary
    cd00060
    Location:499 → 599
    FHA; Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins ...
    cd01365
    Location:4 → 355
    KISc_KIF1A_KIF1B; Kinesin motor domain, KIF1_like proteins
    pfam16183
    Location:352 → 522
    Kinesin_assoc; Kinesin-associated

  6. XM_006532322.5 → XP_006532385.1  kinesin-like protein KIF1C isoform X2

    See identical proteins and their annotated locations for XP_006532385.1

    UniProtKB/Swiss-Prot
    O35071, Q5SX62
    UniProtKB/TrEMBL
    Q8VI89
    Conserved Domains (3) summary
    cd00060
    Location:499 → 599
    FHA; Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins ...
    cd01365
    Location:4 → 355
    KISc_KIF1A_KIF1B; Kinesin motor domain, KIF1_like proteins
    pfam16183
    Location:352 → 522
    Kinesin_assoc; Kinesin-associated

  7. XM_036156352.1 → XP_036012245.1  kinesin-like protein KIF1C isoform X1

    UniProtKB/TrEMBL
    E9Q9B0, Q6A011
    Conserved Domains (3) summary
    cd00060
    Location:499 → 599
    FHA; Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins ...
    cd01365
    Location:4 → 355
    KISc_KIF1A_KIF1B; Kinesin motor domain, KIF1_like proteins
    pfam16183
    Location:352 → 522
    Kinesin_assoc; Kinesin-associated

  8. XM_036156355.1 → XP_036012248.1  kinesin-like protein KIF1C isoform X3

    Conserved Domains (2) summary
    cd00060
    Location:14 → 114
    FHA; Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins ...
    pfam16183
    Location:11 → 37
    Kinesin_assoc; Kinesin-associated

  9. XM_036156356.1 → XP_036012249.1  kinesin-like protein KIF1C isoform X5

RNA

  1. XR_003949317.2 RNA Sequence

Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
O35071.2 GenPept UniProtKB/Swiss-Prot:O35071

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