Krt15 keratin 15 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Krt15provided by MGI
Official Full Name: keratin 15provided by MGI
Primary source: MGI:MGI:96689
See related: Ensembl:ENSMUSG00000054146 AllianceGenome:MGI:96689
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: K15; Krt1-15
Summary: Predicted to enable scaffold protein binding activity. Predicted to be involved in epithelial cell differentiation and intermediate filament organization. Predicted to be located in intermediate filament. Predicted to be active in cytoskeleton. Is expressed in several structures, including alimentary system; genitourinary system; respiratory system; sensory organ; and skin. Orthologous to human KRT15 (keratin 15). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Biased expression in bladder adult (RPKM 231.5), limb E14.5 (RPKM 52.7) and 1 other tissue See more
Orthologs: human all
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Genomic context

Location:: 11 D; 11 63.41 cM

Exon count:: 8

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	11	NC_000077.7 (100022585..100026775, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	11	NC_000077.6 (100131759..100135949, complement)

Chromosome 11 - NC_000077.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Keratin 15 protects against cigarette smoke-induced epithelial mesenchymal transformation by MMP-9.
Title: Keratin 15 protects against cigarette smoke-induced epithelial mesenchymal transformation by MMP-9.
Krt14 and Krt15 differentially regulate regenerative properties and differentiation potential of airway basal cells.
Title: Krt14 and Krt15 differentially regulate regenerative properties and differentiation potential of airway basal cells.
These results indicate that Krt15 marks long-lived, multipotent, and injury-resistant crypt cells that may function as a cell of origin in intestinal cancer.
Title: Mouse Intestinal Krt15+ Crypt Cells Are Radio-Resistant and Tumor Initiating.
A keratin 15 containing stem cell population from the hair follicle contributes to squamous papilloma development in the mouse.
Title: A keratin 15 containing stem cell population from the hair follicle contributes to squamous papilloma development in the mouse.
Krt5 may be a novel biological marker for acute radiation symptoms.
Title: Damage of hair follicle stem cells and alteration of keratin expression in external radiation-induced acute alopecia.
K15 protein expression may reflect not only expression in a stem or progenitor cell subpopulation, but also reflects the activity and responsiveness of basal-like cells to loss of homeostasis of the epidermal differentiation program.
Title: Re-assessing K15 as an epidermal stem cell marker.

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (4) 1 citation
Targeted (1)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

AI528832 (e-PCR)
- UniSTS:180315

Krt1-15 (e-PCR), detects polymorphism
- UniSTS:143738

Krt15 (e-PCR), detects polymorphism
- UniSTS:474754

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables scaffold protein binding	ISO Inferred from Sequence Orthology more info
enables structural molecule activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in epithelial cell differentiation	IBA Inferred from Biological aspect of Ancestor more info
involved_in intermediate filament organization	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
is_active_in cytoskeleton	IBA Inferred from Biological aspect of Ancestor more info
located_in intermediate filament	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: keratin, type I cytoskeletal 15

Names: CK-15; cytokeratin-15; keratin complex 1, acidic, gene 15

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.