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Lsp1 lymphocyte specific 1 [ Mus musculus (house mouse) ]

Gene ID: 16985, updated on 2-Nov-2024

Summary

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Official Symbol
Lsp1provided by MGI
Official Full Name
lymphocyte specific 1provided by MGI
Primary source
MGI:MGI:96832
See related
Ensembl:ENSMUSG00000018819 AllianceGenome:MGI:96832
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
p50; WP34; pp52; Lsp-1
Summary
Predicted to enable actin binding activity. Acts upstream of or within cellular response to interleukin-7; chemotaxis; and defense response. Predicted to be located in plasma membrane. Is expressed in several structures, including alimentary system; genitourinary system; hair follicle; respiratory system; and thymus. Orthologous to human LSP1 (lymphocyte specific protein 1). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Broad expression in subcutaneous fat pad adult (RPKM 85.1), bladder adult (RPKM 70.0) and 17 other tissues See more
Orthologs
human all
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Genomic context

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See Lsp1 in Genome Data Viewer
Location:
7 F5; 7 87.93 cM
Exon count:
15
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 7 NC_000073.7 (142014583..142048605)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 7 NC_000073.6 (142458223..142494868)

Chromosome 7 - NC_000073.7Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_20508 Neighboring gene synaptotagmin VIII Neighboring gene troponin I, skeletal, fast 2 Neighboring gene STARR-positive B cell enhancer ABC_E10483 Neighboring gene proline rich 33 Neighboring gene troponin T3, skeletal, fast Neighboring gene CapStarr-seq enhancer MGSCv37_chr7:149724284-149724471 Neighboring gene mitochondrial ribosomal protein L23

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. LSP1 is an endothelial gatekeeper of leukocyte transendothelial migration. Liu L, et al. J Exp Med, 2005 Feb 7. PMID 15684321, Free PMC Article
  2. A new lymphocyte-specific gene which encodes a putative Ca2+-binding protein is not expressed in transformed T lymphocyte lines. Jongstra J, et al. J Immunol, 1988 Dec 1. PMID 3263441
  3. Protein kinase C phosphorylates p50 LSP1 and induces translocation of p50 LSP1 in T lymphocytes. Matsumoto N, et al. J Biochem, 1995 Jan. PMID 7775393
  4. The LSP1 gene is expressed in cultured normal and transformed mouse macrophages. Jongstra J, et al. Mol Immunol, 1994 Oct. PMID 7935501
  5. Characterization of the 50 kDa protein phosphorylated in concanavalin A-stimulated mouse T cells. Matsumoto N, et al. J Biochem, 1993 May. PMID 8340356

See all (53) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Lymphocyte-Specific Protein 1 Regulates Expression and Stability of Endothelial Nitric Oxide Synthase.
    Title: Lymphocyte-Specific Protein 1 Regulates Expression and Stability of Endothelial Nitric Oxide Synthase.
  2. Lymphocyte-Specific Protein-1 Suppresses Xenobiotic-Induced Constitutive Androstane Receptor and Subsequent Yes-Associated Protein-Activated Hepatocyte Proliferation.
    Title: Lymphocyte-Specific Protein-1 Suppresses Xenobiotic-Induced Constitutive Androstane Receptor and Subsequent Yes-Associated Protein-Activated Hepatocyte Proliferation.
  3. LSP1-myosin1e bimolecular complex regulates focal adhesion dynamics and cell migration.
    Title: LSP1-myosin1e bimolecular complex regulates focal adhesion dynamics and cell migration.
  4. Regulation of O-GlcNAcylation and phosphorylation of lymphocyte-specific protein-1 (Lsp1) is a key switch that triggers apoptosis in activated B cells. O-GlcNAcylation at S209 of Lsp1 is a prerequisite for the recruitment of its kinase, PKC-beta1, to induce S243 phosphorylation.
    Title: Temporal regulation of Lsp1 O-GlcNAcylation and phosphorylation during apoptosis of activated B cells.
  5. the LSP1-myosin1e bimolecular complex plays a pivotal role in the regulation of actin cytoskeleton remodeling during Fc gamma receptor-driven phagocytosis.
    Title: Crucial role for the LSP1-myosin1e bimolecular complex in the regulation of Fcγ receptor-driven phagocytosis.
  6. the importance of LSP1 Copy number variations and LSP1 insufficiency in the pathogenesis of rheumatoid arthritis, is reported.
    Title: Leukocyte-specific protein 1 regulates T-cell migration in rheumatoid arthritis.
  7. Data indicate that in lymphocyte specific 1 protein (LSP1)-deficient mice, PECAM-1 expression was reduced in endothelial cells, but not in neutrophils.
    Title: Endothelial LSP1 Modulates Extravascular Neutrophil Chemotaxis by Regulating Nonhematopoietic Vascular PECAM-1 Expression.
  8. functions as a negative regulator of proliferation and migration in liver
    Title: Leukocyte-specific protein 1: a novel regulator of hepatocellular proliferation and migration deleted in human hepatocellular carcinoma.
  9. TRAF1 and LSP1 cooperate downstream of 4-1BB to activate ERK signaling and down-modulate the levels of Bim leading to enhanced T cell survival.
    Title: Leukocyte-specific protein 1 links TNF receptor-associated factor 1 to survival signaling downstream of 4-1BB in T cells.
  10. Endothelial LSP1 participates in leukocyte adhesion in vitro, and leukocyte adhesion, through ICAM-1, fosters the activation of endothelial LSP1.
    Title: ICAM-1-mediated leukocyte adhesion is critical for the activation of endothelial LSP1.
Submit: New GeneRIF Correction See all GeneRIFs (17)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (1) 
  • Targeted (1)  1 citation

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables actin binding TAS
Traceable Author Statement
more info
 PubMed 
Process Evidence Code Pubs
acts_upstream_of_or_within apoptotic process TAS
Traceable Author Statement
more info
 PubMed 
acts_upstream_of_or_within cellular response to interleukin-7 IDA
Inferred from Direct Assay
more info
 PubMed 
acts_upstream_of_or_within chemotaxis IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within cytoskeleton organization TAS
Traceable Author Statement
more info
 PubMed 
acts_upstream_of_or_within defense response IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in signal transduction IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in plasma membrane IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
lymphocyte-specific protein 1
Names
52 kDa phosphoprotein
S37 protein
leukocyte specific protein 1
lymphocyte-specific antigen WP34

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001136071.3 → NP_001129543.1  lymphocyte-specific protein 1 isoform 1

    See identical proteins and their annotated locations for NP_001129543.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) encodes the longest isoform (1). Both variants 1 and 5 encode the same isoform (1).
    Source sequence(s)
    AL603651
    Consensus CDS
    CCDS52450.1
    UniProtKB/Swiss-Prot
    A2A6J5, A2A6J6, P19973, P97339, Q04950, Q62022, Q62023, Q62024, Q8CD28, Q99L65
    Related
    ENSMUSP00000018963.5, ENSMUST00000018963.11
    Conserved Domains (1) summary
    pfam02029
    Location:118 → 276
    Caldesmon; Caldesmon

  2. NM_001271508.2 → NP_001258437.1  lymphocyte-specific protein 1 isoform 3

    See identical proteins and their annotated locations for NP_001258437.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) contains an alternate 5'-most exon, initiates translation at an alternate start codon and uses an alternate in-frame splice site in the coding region compared to variant 1. The encoded isoform (3) has a distinct N-terminus and is shorter than isoform 1.
    Source sequence(s)
    AL603651
    Consensus CDS
    CCDS72073.1
    UniProtKB/TrEMBL
    A2A6J4
    Related
    ENSMUSP00000101586.2, ENSMUST00000105966.2
    Conserved Domains (1) summary
    pfam02029
    Location:116 → 268
    Caldesmon; Caldesmon

  3. NM_001271509.2 → NP_001258438.1  lymphocyte-specific protein 1 isoform 4

    Status: VALIDATED

    Description
    Transcript Variant: This variant (4) uses an alternate in-frame splice site in the coding region, compared to variant 1. This results in a shorter protein (isoform 4), compared to isoform 1. Variants 4 and 7 both encode the same isoform (4).
    Source sequence(s)
    AL603651
    Consensus CDS
    CCDS72072.1
    UniProtKB/TrEMBL
    A2A6J7
    Related
    ENSMUSP00000101587.2, ENSMUST00000105967.8
    Conserved Domains (1) summary
    pfam02029
    Location:176 → 270
    Caldesmon

  4. NM_001271510.2 → NP_001258439.1  lymphocyte-specific protein 1 isoform 1

    See identical proteins and their annotated locations for NP_001258439.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (5) differs in the 3' UTR compared to variant 1. Both variants 1 and 5 encode the same isoform (1).
    Source sequence(s)
    AL603651
    Consensus CDS
    CCDS52450.1
    UniProtKB/Swiss-Prot
    A2A6J5, A2A6J6, P19973, P97339, Q04950, Q62022, Q62023, Q62024, Q8CD28, Q99L65
    Related
    ENSMUSP00000101588.2, ENSMUST00000105968.8
    Conserved Domains (1) summary
    pfam02029
    Location:118 → 276
    Caldesmon; Caldesmon

  5. NM_001271523.1 → NP_001258452.1  lymphocyte-specific protein 1 isoform 5

    See identical proteins and their annotated locations for NP_001258452.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (6) contains an alternate 5'-most exon, uses an alternate splice site in the 5' UTR and initiates translation at a in-frame downstream start codon compared to variant 1. The encoded isoform (5) has a shorter N-terminus compared to isoform 1. Variants 6 and 10-15 all encode the same isoform (5).
    Source sequence(s)
    AK075783, BX631130
    Consensus CDS
    CCDS85469.1
    UniProtKB/TrEMBL
    A0A1B0GRF5
    Related
    ENSMUSP00000147500.2, ENSMUST00000149521.8

  6. NM_001412663.1 → NP_001399592.1  lymphocyte-specific protein 1 isoform 4

    Status: VALIDATED

    Source sequence(s)
    AL603651
    UniProtKB/TrEMBL
    A2A6J7

  7. NM_001412664.1 → NP_001399593.1  lymphocyte-specific protein 1 isoform 6

    Status: VALIDATED

    Source sequence(s)
    AL603651

  8. NM_001412665.1 → NP_001399594.1  lymphocyte-specific protein 1 isoform 7

    Status: VALIDATED

    Source sequence(s)
    AL603651

  9. NM_001412666.1 → NP_001399595.1  lymphocyte-specific protein 1 isoform 5

    Status: VALIDATED

    Source sequence(s)
    AL603651
    UniProtKB/TrEMBL
    A0A1B0GRF5

  10. NM_001412667.1 → NP_001399596.1  lymphocyte-specific protein 1 isoform 5

    Status: VALIDATED

    Source sequence(s)
    AL603651
    UniProtKB/TrEMBL
    A0A1B0GRF5

  11. NM_001412668.1 → NP_001399597.1  lymphocyte-specific protein 1 isoform 5

    Status: VALIDATED

    Source sequence(s)
    AL603651
    UniProtKB/TrEMBL
    A0A1B0GRF5

  12. NM_001412669.1 → NP_001399598.1  lymphocyte-specific protein 1 isoform 5

    Status: VALIDATED

    Source sequence(s)
    AL603651
    UniProtKB/TrEMBL
    A0A1B0GRF5

  13. NM_001412670.1 → NP_001399599.1  lymphocyte-specific protein 1 isoform 5

    Status: VALIDATED

    Source sequence(s)
    AL603651
    UniProtKB/TrEMBL
    A0A1B0GRF5

  14. NM_001412671.1 → NP_001399600.1  lymphocyte-specific protein 1 isoform 5

    Status: VALIDATED

    Source sequence(s)
    AL603651
    UniProtKB/TrEMBL
    A0A1B0GRF5

  15. NM_001412672.1 → NP_001399601.1  lymphocyte-specific protein 1 isoform 8

    Status: VALIDATED

    Source sequence(s)
    AL603651

  16. NM_001412673.1 → NP_001399602.1  lymphocyte-specific protein 1 isoform 8

    Status: VALIDATED

    Source sequence(s)
    AL603651

  17. NM_019391.4 → NP_062264.1  lymphocyte-specific protein 1 isoform 2

    See identical proteins and their annotated locations for NP_062264.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) contains an alternate 5'-most exon and initiates translation at an alternate start codon compared to variant 1. The encoded isoform (2) has a distinct N-terminus and is shorter than isoform 1.
    Source sequence(s)
    AL603651
    Consensus CDS
    CCDS40193.1
    UniProtKB/Swiss-Prot
    P19973
    Related
    ENSMUSP00000040637.3, ENSMUST00000038946.9
    Conserved Domains (1) summary
    pfam02029
    Location:116 → 274
    Caldesmon; Caldesmon

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000073.7 Reference GRCm39 C57BL/6J

    Range
    142014583..142048605
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_036152722.1 → XP_036008615.1  lymphocyte-specific protein 1 isoform X2

    Conserved Domains (1) summary
    pfam02029
    Location:169 → 263
    Caldesmon

  2. XM_006508494.3 → XP_006508557.1  lymphocyte-specific protein 1 isoform X1

    See identical proteins and their annotated locations for XP_006508557.1

    Conserved Domains (1) summary
    pfam02029
    Location:186 → 280
    Caldesmon

  3. XM_006508495.3 → XP_006508558.1  lymphocyte-specific protein 1 isoform X1

    See identical proteins and their annotated locations for XP_006508558.1

    Conserved Domains (1) summary
    pfam02029
    Location:186 → 280
    Caldesmon

  4. XM_006508496.3 → XP_006508559.1  lymphocyte-specific protein 1 isoform X3

    Conserved Domains (1) summary
    pfam02029
    Location:180 → 274
    Caldesmon

  5. XM_030242182.2 → XP_030098042.1  lymphocyte-specific protein 1 isoform X3

    Conserved Domains (1) summary
    pfam02029
    Location:180 → 274
    Caldesmon
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P19973.2 GenPept UniProtKB/Swiss-Prot:P19973

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