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gria2a glutamate receptor, ionotropic, AMPA 2a [ Danio rerio (zebrafish) ]

Gene ID: 170450, updated on 4-Jan-2025

Summary

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Official Symbol
gria2aprovided by ZNC
Official Full Name
glutamate receptor, ionotropic, AMPA 2aprovided by ZNC
Primary source
ZFIN:ZDB-GENE-020125-3
See related
Ensembl:ENSDARG00000070173 AllianceGenome:ZFIN:ZDB-GENE-020125-3
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Danio rerio
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as
glur2a; gria2.1; zfGRIA2[a]
Summary
Predicted to enable ligand-gated monoatomic ion channel activity and signaling receptor activity. Acts upstream of or within several processes, including embryonic cranial skeleton morphogenesis; mechanosensory lateral line system development; and neural crest cell development. Predicted to be located in postsynaptic membrane. Is expressed in nervous system. Orthologous to human GRIA2 (glutamate ionotropic receptor AMPA type subunit 2). [provided by Alliance of Genome Resources, Jan 2025]
Orthologs
all
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Genomic context

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See gria2a in Genome Data Viewer
Location:
chromosome: 1
Exon count:
17
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCz11 (GCF_000002035.6) 1 NC_007112.7 (21331599..21409890, complement)
105 previous assembly GRCz10 (GCF_000002035.5) 1 NC_007112.6 (20638662..20716968, complement)

Chromosome 1 - NC_007112.7Genomic Context describing neighboring genes Neighboring gene transmembrane protein 144a Neighboring gene mediator complex subunit 28 Neighboring gene uncharacterized LOC137490005 Neighboring gene glycine receptor, beta a

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • BioProject: PRJEB1986
  • Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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Related articles in PubMed

  1. A real-time PCR method for the quantitative analysis of RNA editing at specific sites. Chen YC, et al. Anal Biochem, 2008 Apr 1. PMID 18252192
  2. Embryonic Hyperglycemia Delays the Development of Retinal Synapses in a Zebrafish Model. Shrestha AP, et al. Int J Mol Sci, 2022 Aug 26. PMID 36077087, Free PMC Article
  3. Ultrastructural analysis of the glutamatergic system in the outer plexiform layer of zebrafish retina. Klooster J, et al. J Chem Neuroanat, 2009 Jul. PMID 19481010
  4. Ethanol Preference Leads to Alterations in Telomere Length, Mitochondria Copy Number, and Antioxidant Enzyme Activity in Zebrafish Brains. Moraes IB, et al. Front Biosci (Landmark Ed), 2023 Apr 14. PMID 37114543
  5. PKCgamma-induced trafficking of AMPA receptors in embryonic zebrafish depends on NSF and PICK1. Patten SA, et al. Proc Natl Acad Sci U S A, 2009 Apr 21. PMID 19366675, Free PMC Article

See all (29) citations in PubMed

GeneRIFs: Gene References Into Functions

General gene information

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Homology

Gene Ontology Provided by ZFIN

Function Evidence Code Pubs
enables ligand-gated monoatomic ion channel activity IEA
Inferred from Electronic Annotation
more info
  
enables monoatomic ion channel activity IEA
Inferred from Electronic Annotation
more info
  
enables signaling receptor activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within anterior lateral line development IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within embryonic cranial skeleton morphogenesis IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within monoatomic ion transmembrane transport IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within monoatomic ion transport IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within nervous system development IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within neural crest cell development IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within posterior lateral line system development IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
located_in plasma membrane IEA
Inferred from Electronic Annotation
more info
  
located_in postsynaptic membrane IEA
Inferred from Electronic Annotation
more info
  
located_in synapse IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
glutamate receptor 2a
Names
glutamate receptor, ionotropic, AMPA 2.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_131894.1 → NP_571969.1  glutamate receptor 2a precursor

    See identical proteins and their annotated locations for NP_571969.1

    Status: PROVISIONAL

    Source sequence(s)
    AF525743
    UniProtKB/TrEMBL
    Q71E63
    Related
    ENSDARP00000093557.3, ENSDART00000102782.5
    Conserved Domains (4) summary
    cd13715
    Location:406 → 783
    PBP2_iGluR_AMPA; The ligand-binding domain of the AMPA (alpha-amino-3-hydroxyl-5-methyl-4-isoxazolepropionic acid) subtypes of ionotropic glutamate receptors, a member of the type 2 periplasmic binding fold protein superfamily
    pfam00060
    Location:538 → 816
    Lig_chan; Ligand-gated ion channel
    pfam01094
    Location:51 → 373
    ANF_receptor; Receptor family ligand binding region
    cl10011
    Location:23 → 391
    Periplasmic_Binding_Protein_Type_1; Type 1 periplasmic binding fold superfamily

RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

  1. NC_007112.7 Reference GRCz11 Primary Assembly

    Range
    21331599..21409890 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_005170897.4 → XP_005170954.1  glutamate receptor 2a isoform X2

    UniProtKB/TrEMBL
    A0A8M2BI34
    Conserved Domains (4) summary
    cd13715
    Location:406 → 786
    PBP2_iGluR_AMPA; The ligand-binding domain of the AMPA (alpha-amino-3-hydroxyl-5-methyl-4-isoxazolepropionic acid) subtypes of ionotropic glutamate receptors, a member of the type 2 periplasmic binding fold protein superfamily
    pfam00060
    Location:538 → 816
    Lig_chan; Ligand-gated ion channel
    pfam01094
    Location:51 → 373
    ANF_receptor; Receptor family ligand binding region
    cl10011
    Location:23 → 391
    Periplasmic_Binding_Protein_Type_1; Type 1 periplasmic binding fold superfamily

  2. XM_005170896.3 → XP_005170953.1  glutamate receptor 2a isoform X1

    UniProtKB/TrEMBL
    A0A8M2BIL5
    Conserved Domains (4) summary
    cd13715
    Location:406 → 783
    PBP2_iGluR_AMPA; The ligand-binding domain of the AMPA (alpha-amino-3-hydroxyl-5-methyl-4-isoxazolepropionic acid) subtypes of ionotropic glutamate receptors, a member of the type 2 periplasmic binding fold protein superfamily
    pfam00060
    Location:538 → 816
    Lig_chan; Ligand-gated ion channel
    pfam01094
    Location:51 → 373
    ANF_receptor; Receptor family ligand binding region
    cl10011
    Location:23 → 391
    Periplasmic_Binding_Protein_Type_1; Type 1 periplasmic binding fold superfamily

  3. XM_005170898.4 → XP_005170955.1  glutamate receptor 2a isoform X3

    UniProtKB/TrEMBL
    A0A8M2BI57
    Conserved Domains (4) summary
    cd13715
    Location:406 → 786
    PBP2_iGluR_AMPA; The ligand-binding domain of the AMPA (alpha-amino-3-hydroxyl-5-methyl-4-isoxazolepropionic acid) subtypes of ionotropic glutamate receptors, a member of the type 2 periplasmic binding fold protein superfamily
    pfam00060
    Location:538 → 816
    Lig_chan; Ligand-gated ion channel
    pfam01094
    Location:51 → 373
    ANF_receptor; Receptor family ligand binding region
    cl10011
    Location:23 → 391
    Periplasmic_Binding_Protein_Type_1; Type 1 periplasmic binding fold superfamily

Reference GRCz11 ALT_DRER_TU_1

Genomic

  1. NW_018394477.1 Reference GRCz11 ALT_DRER_TU_1

    Range
    220314..296659 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Reference GRCz11 ALT_DRER_TU_3

Genomic

  1. NW_018395372.1 Reference GRCz11 ALT_DRER_TU_3

    Range
    213065..289388 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version

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