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meis2a Meis homeobox 2a [ Danio rerio (zebrafish) ]

Gene ID: 170454, updated on 14-Nov-2024

Summary

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Official Symbol
meis2aprovided by ZNC
Official Full Name
Meis homeobox 2aprovided by ZNC
Primary source
ZFIN:ZDB-GENE-020122-2
See related
Ensembl:ENSDARG00000098240 AllianceGenome:ZFIN:ZDB-GENE-020122-2
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Danio rerio
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as
fa26d08; meis2.2; wu:fa26d08
Summary
Predicted to enable DNA-binding transcription activator activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Acts upstream of or within embryonic viscerocranium morphogenesis. Predicted to be active in nucleus. Is expressed in several structures, including anterior neural keel; hindbrain neural keel; nervous system; neural plate; and neural rod. Human ortholog(s) of this gene implicated in cleft palate; cleft palate, cardiac defects, and intellectual disabillity; learning disability; open-angle glaucoma; and orofacial cleft. Orthologous to human MEIS2 (Meis homeobox 2). [provided by Alliance of Genome Resources, Nov 2024]
Orthologs
human mouse all
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Genomic context

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See meis2a in Genome Data Viewer
Location:
chromosome: 17
Exon count:
14
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCz11 (GCF_000002035.6) 17 NC_007128.7 (52822362..52921237)
105 previous assembly GRCz10 (GCF_000002035.5) 17 NC_007128.6 (52735916..52835155)

Chromosome 17 - NC_007128.7Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC137488151 Neighboring gene trichohyalin-like Neighboring gene uncharacterized LOC110438055 Neighboring gene CDAN1 interacting nuclease 1 Neighboring gene diphthamine biosynthesis 6

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • BioProject: PRJEB1986
  • Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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Related articles in PubMed

  1. Phylogeny of the teashirt-related zinc finger (tshz) gene family and analysis of the developmental expression of tshz2 and tshz3b in the zebrafish. Santos JS, et al. Dev Dyn, 2010 Mar. PMID 20108322
  2. meis1 regulates cyclin D1 and c-myc expression, and controls the proliferation of the multipotent cells in the early developing zebrafish eye. Bessa J, et al. Development, 2008 Mar. PMID 18216175
  3. Enhancers reside in a unique epigenetic environment during early zebrafish development. Kaaij LJ, et al. Genome Biol, 2016 Jul 5. PMID 27381023, Free PMC Article
  4. Transcriptome-wide subtyping of pediatric and adult T cell acute lymphoblastic leukemia in an international study of 707 cases. Dai YT, et al. Proc Natl Acad Sci U S A, 2022 Apr 12. PMID 35385357, Free PMC Article
  5. Hoxa2 selectively enhances Meis binding to change a branchial arch ground state. Amin S, et al. Dev Cell, 2015 Feb 9. PMID 25640223, Free PMC Article

See all (15) citations in PubMed

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Gene Ontology Provided by ZFIN

Function Evidence Code Pubs
enables DNA binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within embryonic viscerocranium morphogenesis IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within regulation of DNA-templated transcription IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
homeobox protein Meis2a
Names
myeloid ecotropic viral integration site 2.2
myeloid ecotropic viral integration site 2a

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_131896.1 → NP_571971.1  homeobox protein Meis2a

    See identical proteins and their annotated locations for NP_571971.1

    Status: PROVISIONAL

    Source sequence(s)
    BC056515
    UniProtKB/TrEMBL
    Q6PHK8
    Related
    ENSDARP00000155813.1, ENSDART00000193368.1
    Conserved Domains (2) summary
    pfam05920
    Location:290 → 329
    Homeobox_KN; Homeobox KN domain
    pfam16493
    Location:106 → 189
    Meis_PKNOX_N; N-terminal of Homeobox Meis and PKNOX1

RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

  1. NC_007128.7 Reference GRCz11 Primary Assembly

    Range
    52822362..52921237
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_009293340.4 → XP_009291615.1  homeobox protein Meis2a isoform X1

    UniProtKB/TrEMBL
    A0A8M3AK57
    Conserved Domains (2) summary
    pfam05920
    Location:302 → 341
    Homeobox_KN; Homeobox KN domain
    pfam16493
    Location:106 → 189
    Meis_PKNOX_N; N-terminal of Homeobox Meis and PKNOX1

  2. XM_009293343.4 → XP_009291618.1  homeobox protein Meis2a isoform X4

    UniProtKB/TrEMBL
    A0A8M3AJB0
    Conserved Domains (2) summary
    pfam05920
    Location:302 → 341
    Homeobox_KN; Homeobox KN domain
    pfam16493
    Location:106 → 189
    Meis_PKNOX_N; N-terminal of Homeobox Meis and PKNOX1

  3. XM_009293342.4 → XP_009291617.1  homeobox protein Meis2a isoform X3

    UniProtKB/TrEMBL
    A0A8M3ARP6
    Conserved Domains (2) summary
    pfam05920
    Location:301 → 340
    Homeobox_KN; Homeobox KN domain
    pfam16493
    Location:106 → 189
    Meis_PKNOX_N; N-terminal of Homeobox Meis and PKNOX1

  4. XM_009293345.3 → XP_009291620.1  homeobox protein Meis2a isoform X6

    UniProtKB/TrEMBL
    A0A0H2UKR5, A0A8M3AK61
    Related
    ENSDARP00000137649.1, ENSDART00000161414.2
    Conserved Domains (2) summary
    pfam05920
    Location:290 → 329
    Homeobox_KN; Homeobox KN domain
    pfam16493
    Location:106 → 189
    Meis_PKNOX_N; N-terminal of Homeobox Meis and PKNOX1

  5. XM_009293344.4 → XP_009291619.1  homeobox protein Meis2a isoform X5

    UniProtKB/TrEMBL
    A0A8M3B2P5
    Conserved Domains (2) summary
    pfam05920
    Location:289 → 328
    Homeobox_KN; Homeobox KN domain
    pfam16493
    Location:106 → 189
    Meis_PKNOX_N; N-terminal of Homeobox Meis and PKNOX1

  6. XM_009293346.4 → XP_009291621.1  homeobox protein Meis2a isoform X7

    UniProtKB/TrEMBL
    A0A8M3AUM6
    Conserved Domains (2) summary
    pfam05920
    Location:289 → 328
    Homeobox_KN; Homeobox KN domain
    pfam16493
    Location:106 → 189
    Meis_PKNOX_N; N-terminal of Homeobox Meis and PKNOX1

  7. XM_009293341.4 → XP_009291616.1  homeobox protein Meis2a isoform X2

    UniProtKB/TrEMBL
    A0A8M3AUL9
    Related
    ENSDARP00000153019.1, ENSDART00000186979.1
    Conserved Domains (2) summary
    pfam05920
    Location:301 → 340
    Homeobox_KN; Homeobox KN domain
    pfam16493
    Location:105 → 188
    Meis_PKNOX_N; N-terminal of Homeobox Meis and PKNOX1
Nucleotide Protein Strain
Heading Accession and Version

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