Gpha2 glycoprotein hormone alpha 2 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Gpha2provided by MGI
Official Full Name: glycoprotein hormone alpha 2provided by MGI
Primary source: MGI:MGI:2156541
See related: Ensembl:ENSMUSG00000024784 AllianceGenome:MGI:2156541
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: GPA2; zsig51
Summary: Predicted to enable protein heterodimerization activity and thyrotropin-releasing hormone receptor binding activity. Predicted to be involved in adenylate cyclase-activating G protein-coupled receptor signaling pathway and cell surface receptor signaling pathway. Predicted to be located in extracellular region. Predicted to be active in extracellular space. Is expressed in Rathke's pouch; adenohypophysis pars anterior; adenohypophysis pars intermedia; and neurohypophysis. Orthologous to human GPHA2 (glycoprotein hormone subunit alpha 2). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Biased expression in adrenal adult (RPKM 89.2) and ovary adult (RPKM 21.7) See more
Orthologs: human all
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Genomic context

Location:: 19 A; 19 4.35 cM

Exon count:: 4

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	19	NC_000085.7 (6276431..6277798)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	19	NC_000085.6 (6226401..6227768)

Chromosome 19 - NC_000085.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

expressed in newborn skulls and long bones but declined rapidly thereafter
Title: Thyrostimulin Regulates Osteoblastic Bone Formation During Early Skeletal Development.

Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (1)

General gene information

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Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables hormone activity	IEA Inferred from Electronic Annotation more info
enables protein heterodimerization activity	IEA Inferred from Electronic Annotation more info
enables protein heterodimerization activity	ISO Inferred from Sequence Orthology more info
enables thyrotropin-releasing hormone receptor binding	IBA Inferred from Biological aspect of Ancestor more info
enables thyrotropin-releasing hormone receptor binding	IEA Inferred from Electronic Annotation more info
enables thyrotropin-releasing hormone receptor binding	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in adenylate cyclase-activating G protein-coupled receptor signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in adenylate cyclase-activating G protein-coupled receptor signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in cell surface receptor signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
involved_in cell surface receptor signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in cell surface receptor signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in regulation of signal transduction	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in extracellular region	ISO Inferred from Sequence Orthology more info	PubMed
is_active_in extracellular space	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: glycoprotein hormone alpha-2

Names: putative secreted protein Zsig51; thyrostimulin subunit alpha

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.