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Recql5 RecQ protein-like 5 [ Mus musculus (house mouse) ]

Gene ID: 170472, updated on 9-Aug-2024

Summary

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Official Symbol
Recql5provided by MGI
Official Full Name
RecQ protein-like 5provided by MGI
Primary source
MGI:MGI:2156841
See related
Ensembl:ENSMUSG00000020752 AllianceGenome:MGI:2156841
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
RecQ5; Recq5b; Recql5b
Summary
Predicted to enable DNA helicase activity; RNA polymerase II complex binding activity; and identical protein binding activity. Acts upstream of or within several processes, including cellular response to camptothecin; negative regulation of double-strand break repair via homologous recombination; and replication-born double-strand break repair via sister chromatid exchange. Predicted to be located in cytosol and nucleoplasm. Predicted to be part of RNA polymerase II, holoenzyme. Predicted to be active in chromosome and cytoplasm. Orthologous to human RECQL5 (RecQ like helicase 5). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in testis adult (RPKM 8.0), large intestine adult (RPKM 8.0) and 28 other tissues See more
Orthologs
human all
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Genomic context

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See Recql5 in Genome Data Viewer
Location:
11 80.91 cM; 11 E2
Exon count:
22
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 11 NC_000077.7 (115783421..115824339, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 11 NC_000077.6 (115892595..115933514, complement)

Chromosome 11 - NC_000077.7Genomic Context describing neighboring genes Neighboring gene STARR-positive B cell enhancer ABC_E3039 Neighboring gene tRNA splicing endonuclease subunit 54 Neighboring gene STARR-seq mESC enhancer starr_31175 Neighboring gene STARR-seq mESC enhancer starr_31178 Neighboring gene LLGL2 scribble cell polarity complex component Neighboring gene myosin XVB Neighboring gene CapStarr-seq enhancer MGSCv37_chr11:115759828-115760025 Neighboring gene small integral membrane protein 5 Neighboring gene STARR-positive B cell enhancer ABC_E1850 Neighboring gene small integral membrane protein 6 Neighboring gene STARR-seq mESC enhancer starr_31180 Neighboring gene STARR-seq mESC enhancer starr_31181 Neighboring gene SAP30 binding protein Neighboring gene predicted gene, 39474 Neighboring gene STARR-seq mESC enhancer starr_31187 Neighboring gene RIKEN cDNA B230344G16 gene Neighboring gene integrin beta 4

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Recql5 protects against lipopolysaccharide/D-galactosamine-induced liver injury in mice. Liao WQ, et al. World J Gastroenterol, 2015 Sep 28. PMID 26420964, Free PMC Article
  2. Recql5 plays an important role in DNA replication and cell survival after camptothecin treatment. Hu Y, et al. Mol Biol Cell, 2009 Jan. PMID 18987339, Free PMC Article
  3. Recql5 and Blm RecQ DNA helicases have nonredundant roles in suppressing crossovers. Hu Y, et al. Mol Cell Biol, 2005 May. PMID 15831450, Free PMC Article
  4. Cloning, genomic structure and chromosomal localization of the gene encoding mouse DNA helicase RECQL5beta. Ohhata T, et al. Gene, 2001 Dec 12. PMID 11738818
  5. Effect of Recql5 deficiency on the intestinal tumor susceptibility of Apc(min) mice. Hu Y, et al. World J Gastroenterol, 2010 Mar 28. PMID 20333788, Free PMC Article

See all (21) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Recql5 protects the liver against LPS/D-Gal-induced injury by suppressing hepatocyte apoptosis and oxidative stress and modulation of CYP450 expression.
    Title: Recql5 protects against lipopolysaccharide/D-galactosamine-induced liver injury in mice.
  2. Recql5 has a tumor suppressor role in the gastrointestinal tract of Apc(min) mice.
    Title: Effect of Recql5 deficiency on the intestinal tumor susceptibility of Apc(min) mice.
  3. Data suggest that Recql5 helps maintain active DNA replication to prevent collapse of replication forks and accumulation of DSBs, preserve genome integrity and prevent cell death after replication stress due to topoisomerase I poisoning.
    Title: Recql5 plays an important role in DNA replication and cell survival after camptothecin treatment.
  4. Recql5-deficient cells exhibit elevated frequencies of spontaneous DNA double-strand breaks and homologous recombination (
    Title: RECQL5/Recql5 helicase regulates homologous recombination and suppresses tumor formation via disruption of Rad51 presynaptic filaments.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (2) 
  • Targeted (2)  1 citation

General gene information

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Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables 3'-5' DNA helicase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables ATP binding IEA
Inferred from Electronic Annotation
more info
  
enables DNA helicase activity ISO
Inferred from Sequence Orthology
more info
  
enables RNA polymerase II complex binding ISO
Inferred from Sequence Orthology
more info
  
enables four-way junction helicase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables helicase activity ISO
Inferred from Sequence Orthology
more info
  
enables hydrolase activity IEA
Inferred from Electronic Annotation
more info
  
enables identical protein binding ISO
Inferred from Sequence Orthology
more info
  
enables nucleic acid binding IEA
Inferred from Electronic Annotation
more info
  
enables nucleotide binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within DNA damage response IEA
Inferred from Electronic Annotation
more info
  
involved_in DNA recombination IEA
Inferred from Electronic Annotation
more info
  
involved_in DNA repair ISO
Inferred from Sequence Orthology
more info
  
involved_in DNA replication ISO
Inferred from Sequence Orthology
more info
  
involved_in DNA unwinding involved in DNA replication IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within cell cycle IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within cell division IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within cellular response to camptothecin IGI
Inferred from Genetic Interaction
more info
 PubMed 
acts_upstream_of_or_within cellular response to camptothecin IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within cellular response to xenobiotic stimulus IGI
Inferred from Genetic Interaction
more info
 PubMed 
acts_upstream_of_or_within cellular response to xenobiotic stimulus IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in chromosome separation ISO
Inferred from Sequence Orthology
more info
  
involved_in double-strand break repair via homologous recombination IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in mitotic DNA-templated DNA replication ISO
Inferred from Sequence Orthology
more info
  
involved_in mitotic cell cycle ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within negative regulation of double-strand break repair via homologous recombination IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in negative regulation of transcription elongation by RNA polymerase II ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within replication-born double-strand break repair via sister chromatid exchange IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
is_active_in chromosome IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytosol ISO
Inferred from Sequence Orthology
more info
  
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
  
located_in nucleus ISO
Inferred from Sequence Orthology
more info
  
is_active_in replication fork ISO
Inferred from Sequence Orthology
more info
  
part_of transcription preinitiation complex ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
ATP-dependent DNA helicase Q5
Names
DNA 3'-5' helicase RecQ5
DNA helicase, RecQ-like type 5
RECQL5beta
NP_569721.1
XP_006532421.1
XP_006532422.1
XP_006532424.1
XP_006532425.1
XP_006532426.1
XP_030101474.1
XP_036012259.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_130454.2 → NP_569721.1  ATP-dependent DNA helicase Q5

    See identical proteins and their annotated locations for NP_569721.1

    Status: VALIDATED

    Source sequence(s)
    AK049269, AL645647, AW049927, BC059000
    Consensus CDS
    CCDS25650.1
    UniProtKB/Swiss-Prot
    Q8BQD7, Q8C7T6, Q8VID3, Q8VID5
    Related
    ENSMUSP00000021097.4, ENSMUST00000021097.10
    Conserved Domains (2) summary
    COG0514
    Location:15 → 439
    RecQ; Superfamily II DNA helicase RecQ [Replication, recombination and repair]
    pfam06959
    Location:626 → 817
    RecQ5; RecQ helicase protein-like 5 (RecQ5)

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000077.7 Reference GRCm39 C57BL/6J

    Range
    115783421..115824339 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006532361.5 → XP_006532424.1  ATP-dependent DNA helicase Q5 isoform X4

    See identical proteins and their annotated locations for XP_006532424.1

    Conserved Domains (2) summary
    COG0514
    Location:1 → 133
    RecQ; Superfamily II DNA helicase RecQ [Replication, recombination and repair]
    pfam06959
    Location:320 → 508
    RecQ5; RecQ helicase protein-like 5 (RecQ5)

  2. XM_006532359.5 → XP_006532422.1  ATP-dependent DNA helicase Q5 isoform X3

    Conserved Domains (2) summary
    COG0514
    Location:6 → 398
    RecQ; Superfamily II DNA helicase RecQ [Replication, recombination and repair]
    pfam06959
    Location:585 → 773
    RecQ5; RecQ helicase protein-like 5 (RecQ5)

  3. XM_006532358.5 → XP_006532421.1  ATP-dependent DNA helicase Q5 isoform X1

    Conserved Domains (2) summary
    COG0514
    Location:16 → 440
    RecQ; Superfamily II DNA helicase RecQ [Replication, recombination and repair]
    pfam06959
    Location:627 → 815
    RecQ5; RecQ helicase protein-like 5 (RecQ5)

  4. XM_036156366.1 → XP_036012259.1  ATP-dependent DNA helicase Q5 isoform X2

    UniProtKB/Swiss-Prot
    Q8BQD7, Q8C7T6, Q8VID3, Q8VID5
    Conserved Domains (2) summary
    COG0514
    Location:15 → 439
    RecQ; Superfamily II DNA helicase RecQ [Replication, recombination and repair]
    pfam06959
    Location:626 → 817
    RecQ5; RecQ helicase protein-like 5 (RecQ5)

  5. XM_006532363.5 → XP_006532426.1  ATP-dependent DNA helicase Q5 isoform X6

    Conserved Domains (2) summary
    pfam06959
    Location:231 → 419
    RecQ5; RecQ helicase protein-like 5 (RecQ5)
    pfam16124
    Location:17 → 40
    RecQ_Zn_bind; RecQ zinc-binding

  6. XM_006532362.4 → XP_006532425.1  ATP-dependent DNA helicase Q5 isoform X5

    Conserved Domains (2) summary
    pfam06959
    Location:231 → 419
    RecQ5; RecQ helicase protein-like 5 (RecQ5)
    pfam16124
    Location:12 → 40
    RecQ_Zn_bind; RecQ zinc-binding

  7. XM_030245614.2 → XP_030101474.1  ATP-dependent DNA helicase Q5 isoform X7

    Conserved Domains (1) summary
    COG0514
    Location:16 → 440
    RecQ; Superfamily II DNA helicase RecQ [Replication, recombination and repair]

RNA

  1. XR_003949325.2 RNA Sequence

  2. XR_003949327.2 RNA Sequence

  3. XR_003949326.2 RNA Sequence

Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q8VID5.1 GenPept UniProtKB/Swiss-Prot:Q8VID5

Gene LinkOut

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