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Zfp287 zinc finger protein 287 [ Mus musculus (house mouse) ]

Gene ID: 170740, updated on 9-Dec-2024

Summary

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Official Symbol
Zfp287provided by MGI
Official Full Name
zinc finger protein 287provided by MGI
Primary source
MGI:MGI:2176561
See related
Ensembl:ENSMUSG00000005267 AllianceGenome:MGI:2176561
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Skat2; SKAT-2; Znf287; mszf16; mszf74; zfp-287; B230333C16Rik
Summary
Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Acts upstream of or within positive regulation of DNA-templated transcription and regulation of cytokine production. Predicted to be active in nucleus. Is expressed in bladder; central nervous system; head; and ureter. Orthologous to human ZNF287 (zinc finger protein 287). [provided by Alliance of Genome Resources, Dec 2024]
Expression
Broad expression in CNS E18 (RPKM 1.9), CNS E14 (RPKM 1.8) and 21 other tissues See more
Orthologs
human all
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Genomic context

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See Zfp287 in Genome Data Viewer
Location:
11 B2; 11 38.62 cM
Exon count:
17
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 11 NC_000077.7 (62583270..62622749, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 11 NC_000077.6 (62692444..62731912, complement)

Chromosome 11 - NC_000077.7Genomic Context describing neighboring genes Neighboring gene leucine rich repeat containing 75A Neighboring gene leucine rich repeat containing 75A, opposite strand 1 Neighboring gene CapStarr-seq enhancer MGSCv37_chr11:62462281-62462390 Neighboring gene membrane magnesium transporter 2 Neighboring gene nuclear encoded tRNA trytophan 8 (anticodon CCA) Neighboring gene WD repeat and SOCS box-containing 2, pseudogene Neighboring gene zinc finger protein 286

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Identification and characterization of SKAT-2, a novel Th2-specific zinc finger gene. Blanchard AD, et al. Eur J Immunol, 2000 Nov. PMID 11093124
  2. Rapid and efficient cloning of cDNAs encoding Krüppel-like zinc finger proteins by degenerate PCR. Agata Y, et al. Gene, 1998 Jun 15. PMID 9630514
  3. Mouse screen reveals multiple new genes underlying mouse and human hearing loss. Ingham NJ, et al. PLoS Biol, 2019 Apr. PMID 30973865, Free PMC Article
  4. A systems approach reveals that the myogenesis genome network is regulated by the transcriptional repressor RP58. Yokoyama S, et al. Dev Cell, 2009 Dec. PMID 20059953, Free PMC Article
  5. High-throughput discovery of novel developmental phenotypes. Dickinson ME, et al. Nature, 2016 Sep 22. PMID 27626380, Free PMC Article

See all (21) citations in PubMed

GeneRIFs: Gene References Into Functions

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (1) 
  • Targeted (2) 

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables DNA binding IEA
Inferred from Electronic Annotation
more info
  
enables DNA-binding transcription factor activity, RNA polymerase II-specific IBA
Inferred from Biological aspect of Ancestor
more info
  
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in positive regulation of DNA-templated transcription IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within positive regulation of DNA-templated transcription IDA
Inferred from Direct Assay
more info
 PubMed 
acts_upstream_of_or_within regulation of cytokine production IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
zinc finger protein 287
Names
zinc finger protein SKAT-2
zinc finger protein SKAT2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001382823.1 → NP_001369752.1  zinc finger protein 287 isoform 2

    Status: VALIDATED

    Source sequence(s)
    AL627097
    UniProtKB/TrEMBL
    Q3UZW0
    Related
    ENSMUSP00000121717.2, ENSMUST00000150336.8
    Conserved Domains (2) summary
    smart00349
    Location:166 → 223
    KRAB; krueppel associated box
    pfam02023
    Location:39 → 122
    SCAN; SCAN domain

  2. NM_001382824.1 → NP_001369753.1  zinc finger protein 287 isoform 3

    Status: VALIDATED

    Source sequence(s)
    AL627097
    UniProtKB/TrEMBL
    Q3UY44
    Related
    ENSMUSP00000117179.2, ENSMUST00000128370.2
    Conserved Domains (2) summary
    smart00349
    Location:166 → 223
    KRAB; krueppel associated box
    pfam02023
    Location:39 → 122
    SCAN; SCAN domain

  3. NM_133208.3 → NP_573471.2  zinc finger protein 287 isoform 1

    See identical proteins and their annotated locations for NP_573471.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (1).
    Source sequence(s)
    AL627097
    Consensus CDS
    CCDS24830.1
    UniProtKB/Swiss-Prot
    Q8CDU3, Q9EQB9
    Related
    ENSMUSP00000005399.4, ENSMUST00000005399.10
    Conserved Domains (5) summary
    smart00349
    Location:166 → 223
    KRAB; krueppel associated box
    COG5048
    Location:420 → 753
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:424 → 444
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00096
    Location:394 → 416
    zf-C2H2; Zinc finger, C2H2 type
    cl02605
    Location:39 → 138
    SCAN; SCAN oligomerization domain

RNA

  1. NR_168576.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AL627097

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000077.7 Reference GRCm39 C57BL/6J

    Range
    62583270..62622749 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_036156368.1 → XP_036012261.1  zinc finger protein 287 isoform X2

    UniProtKB/TrEMBL
    Q3UZW0
    Conserved Domains (2) summary
    smart00349
    Location:166 → 223
    KRAB; krueppel associated box
    pfam02023
    Location:39 → 122
    SCAN; SCAN domain

  2. XM_036156369.1 → XP_036012262.1  zinc finger protein 287 isoform X2

    UniProtKB/TrEMBL
    Q3UZW0
    Conserved Domains (2) summary
    smart00349
    Location:166 → 223
    KRAB; krueppel associated box
    pfam02023
    Location:39 → 122
    SCAN; SCAN domain

  3. XM_036156367.1 → XP_036012260.1  zinc finger protein 287 isoform X1

    Conserved Domains (4) summary
    COG5048
    Location:238 → 571
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:242 → 262
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00096
    Location:212 → 234
    zf-C2H2; Zinc finger, C2H2 type
    cl02581
    Location:3 → 41
    KRAB_A-box; KRAB (Kruppel-associated box) domain -A box

RNA

  1. XR_004936821.1 RNA Sequence

  2. XR_004936817.1 RNA Sequence

  3. XR_004936820.1 RNA Sequence

  4. XR_879531.4 RNA Sequence

  5. XR_004936819.1 RNA Sequence

  6. XR_004936818.1 RNA Sequence

  7. XR_879525.4 RNA Sequence

  8. XR_879527.4 RNA Sequence

  9. XR_004936811.1 RNA Sequence

  10. XR_004936810.1 RNA Sequence

  11. XR_004936812.1 RNA Sequence

  12. XR_001779891.3 RNA Sequence

  13. XR_001779892.3 RNA Sequence

  14. XR_004936809.1 RNA Sequence

  15. XR_004936807.1 RNA Sequence

  16. XR_004936808.1 RNA Sequence

  17. XR_004936816.1 RNA Sequence

  18. XR_004936814.1 RNA Sequence

  19. XR_004936815.1 RNA Sequence

  20. XR_004936813.1 RNA Sequence

Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9EQB9.2 GenPept UniProtKB/Swiss-Prot:Q9EQB9

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