mkrn2 makorin, ring finger protein, 2 [Danio rerio (zebrafish)] - Gene

Summary

Official Symbol: mkrn2provided by ZNC
Official Full Name: makorin, ring finger protein, 2provided by ZNC
Primary source: ZFIN:ZDB-GENE-020213-2
See related: Ensembl:ENSDARG00000007630 AllianceGenome:ZFIN:ZDB-GENE-020213-2
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Danio rerio
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as: hspc070; wu:fb99a04
Summary: Predicted to enable ubiquitin protein ligase activity. Acts upstream of or within retina layer formation. Predicted to be located in cytoplasm and nucleus. Is expressed in several structures, including eye; gill; gonad; integument; and liver. Orthologous to human MKRN2 (makorin ring finger protein 2). [provided by Alliance of Genome Resources, Jan 2025]
Orthologs: human mouse all
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Genomic context

Location:: chromosome: 11

Exon count:: 9

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCz11 (GCF_000002035.6)	11	NC_007122.7 (543366..574478, complement)
105	previous assembly	GRCz10 (GCF_000002035.5)	11	NC_007122.6 (539117..547990, complement)

Chromosome 11 - NC_007122.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
BioProject: PRJEB1986
Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Submit: New GeneRIF Correction

General gene information

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Markers

fb99a04.x1 (e-PCR)
- UniSTS:203625

AI588295 (e-PCR)
- UniSTS:206203

Gene Ontology Provided by ZFIN

Function	Evidence Code	Pubs
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables transferase activity	IEA Inferred from Electronic Annotation more info
enables ubiquitin protein ligase activity	IBA Inferred from Biological aspect of Ancestor more info
enables ubiquitin protein ligase activity	IEA Inferred from Electronic Annotation more info
enables ubiquitin protein ligase activity	ISS Inferred from Sequence or Structural Similarity more info

Process	Evidence Code	Pubs
involved_in DNA-templated transcription	ISS Inferred from Sequence or Structural Similarity more info
acts_upstream_of_or_within cell differentiation	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of inflammatory response to antigenic stimulus	ISS Inferred from Sequence or Structural Similarity more info
involved_in negative regulation of non-canonical NF-kappaB signal transduction	ISS Inferred from Sequence or Structural Similarity more info
acts_upstream_of_or_within nervous system development	IEA Inferred from Electronic Annotation more info
involved_in phosphatidylinositol 3-kinase/protein kinase B signal transduction	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of transcription by RNA polymerase II	ISS Inferred from Sequence or Structural Similarity more info
acts_upstream_of_or_within protein polyubiquitination	IEA Inferred from Electronic Annotation more info
involved_in protein ubiquitination	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within retina layer formation	IGI Inferred from Genetic Interaction more info	PubMed
involved_in ubiquitin-dependent protein catabolic process	ISS Inferred from Sequence or Structural Similarity more info

Component	Evidence Code	Pubs
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
located_in cytoplasm	ISS Inferred from Sequence or Structural Similarity more info
located_in intracellular anatomical structure	ISS Inferred from Sequence or Structural Similarity more info	PubMed
located_in nucleus	IEA Inferred from Electronic Annotation more info
located_in nucleus	ISS Inferred from Sequence or Structural Similarity more info

General protein information

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Preferred Names: E3 ubiquitin-protein ligase makorin-2

Names: RING-type E3 ubiquitin transferase makorin-2; probable E3 ubiquitin-protein ligase makorin-2

NP_694511.1

EC 2.3.2.27

XP_068080200.1

EC 2.3.2.27

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_152979.2 → NP_694511.1 E3 ubiquitin-protein ligase makorin-2

See identical proteins and their annotated locations for NP_694511.1

Status: VALIDATED

Source sequence(s)

AI588295, BC065352, CABZ01008492, CABZ01008493, CN321915

UniProtKB/Swiss-Prot

Q6P0Z6, Q9DFG8

UniProtKB/TrEMBL

A0A0R4I9G0

Related

ENSDARP00000110314.1, ENSDART00000130504.4

Conserved Domains (3) summary

smart00356
Location:35 → 57

ZnF_C3H1; zinc finger

PHA03096
Location:178 → 326

PHA03096; p28-like protein; Provisional

cd00162
Location:237 → 291

RING; RING-finger (Really Interesting New Gene) domain, a specialized type of Zn-finger of 40 to 60 residues that binds two atoms of zinc; defined by the 'cross-brace' motif C-X2-C-X(9-39)-C-X(1-3)- H-X(2-3)-(N/C/H)-X2-C-X(4-48)C-X2-C; probably involved in ...