Camk1 calcium/calmodulin-dependent protein kinase I [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Camk1provided by RGD
Official Full Name: calcium/calmodulin-dependent protein kinase Iprovided by RGD
Primary source: RGD:629473
See related: EnsemblRapid:ENSRNOG00000021781 AllianceGenome:RGD:629473
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: Gaip; Camki
Summary: Enables calmodulin-dependent protein kinase activity. Involved in regulation of synapse organization. Is active in glutamatergic synapse and postsynaptic density. Orthologous to human CAMK1 (calcium/calmodulin dependent protein kinase I). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Biased expression in Heart (RPKM 146.8), Lung (RPKM 142.3) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 4q42

Exon count:: 13

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	4	NC_086022.1 (148036843..148047675, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	4	NC_051339.1 (146481196..146492039, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	4	NC_005103.4 (145289300..145300146, complement)

Chromosome 4 - NC_086022.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Oligomerization of Ca(2+)/calmodulin-dependent protein kinase kinase.
Title: Oligomerization of Ca(2+)/calmodulin-dependent protein kinase kinase.
Furthermore, the effect of CaMKP on self-assembly of NFL was examined. Electron microscopy revealed that CaMKP markedly prevented NFL from forming large filamentous aggregates, suggesting that CaMKP-binding to NFL inhibits its filament association. These findings may provide new insights into a novel mechanism for regulating network formation of neurofilaments during neuronal differentiation.
Title: Ca(2+)/calmodulin-dependent protein kinase phosphatase (CaMKP/PPM1F) interacts with neurofilament L and inhibits its filament association.
expression of CaMKIbeta2 in the retina was detected from the earliest development until adulthood, indicating that CaMKIbeta2 may be required in both proliferation and differentiation of the retinal precursor cells and subsequent formation of the functional layers
Title: Expression of Beta Subunit 2 of Ca²+/Calmodulin-Dependent Protein Kinase I in the Developing Rat Retina.
C-terminal cytoplasmic fragment of PcdhgC5 acts as a scaffold for CaMKP and CaMKI to regulate CaMKP activity.
Title: Regulation of Ca(2+)/calmodulin-dependent protein kinase phosphatase (CaMKP/PPM1F) by protocadherin-γC5 (Pcdh-γC5).
Ca+2/calmodulin-dependent protein kinase mediates glucose toxicity-induced cardiomyocyte contractile dysfunction
Title: Ca+2/calmodulin-dependent protein kinase mediates glucose toxicity-induced cardiomyocyte contractile dysfunction.
Cys179 is an essential site for inactivation of CaMKI by oxidants.
Title: Calcium/calmodulin-dependent protein kinases as potential targets of nitric oxide.
Inflammatory acidic environments activate Trpv1, leading to an up-regulation of CGRP expression via CaMK-CREB cascade, a series of events that may be associated with inflammatory pain.
Title: Acid activation of Trpv1 leads to an up-regulation of calcitonin gene-related peptide expression in dorsal root ganglion neurons via the CaMK-CREB cascade: a potential mechanism of inflammatory pain.
N-methyl-D-aspartate receptor (NMDAR)-dependent activation is required for CAMK1-mediated synaptic expression of divalent calcium ion-positive permeable AMPA receptors.
Title: Long-term potentiation-dependent spine enlargement requires synaptic Ca2+-permeable AMPA receptors recruited by CaM-kinase I.
Calcium calmodulin kinase 1 alpha regulates the functions of ribosomal protein S19 through phosphorylation of Ser59.
Title: Phosphorylation of ribosomal protein S19 at Ser59 by CaM kinase I alpha.
Calcium/calmodulin-dependent protein kinase I activity promotes incorporation of calcium-permeable alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA) receptors at central glutamatergic synapses.
Title: Recruitment of calcium-permeable AMPA receptors during synaptic potentiation is regulated by CaM-kinase I.

Submit: New GeneRIF Correction See all GeneRIFs (13)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

D6Ertd263e (e-PCR), detects polymorphism
- UniSTS:167474

AI505105 (e-PCR)
- UniSTS:159558

RH136941 (e-PCR)
- UniSTS:219030

Camk1 (e-PCR), detects polymorphism
- UniSTS:527275

RH128087 (e-PCR)
- UniSTS:211395

RH137514 (e-PCR)
- UniSTS:219602

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables ATP binding	IEA Inferred from Electronic Annotation more info
enables calmodulin binding	IBA Inferred from Biological aspect of Ancestor more info
enables calmodulin-dependent protein kinase activity	IBA Inferred from Biological aspect of Ancestor more info
enables calmodulin-dependent protein kinase activity	IDA Inferred from Direct Assay more info	PubMed
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein kinase activity	IEA Inferred from Electronic Annotation more info
enables protein serine kinase activity	IEA Inferred from Electronic Annotation more info
enables protein serine/threonine kinase activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in cell differentiation	IEA Inferred from Electronic Annotation more info
involved_in intracellular signal transduction	IEA Inferred from Electronic Annotation more info
involved_in intracellular signal transduction	ISO Inferred from Sequence Orthology more info
involved_in nervous system development	IEA Inferred from Electronic Annotation more info
involved_in nucleocytoplasmic transport	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within nucleocytoplasmic transport	ISO Inferred from Sequence Orthology more info
involved_in peptidyl-serine phosphorylation	IBA Inferred from Biological aspect of Ancestor more info
involved_in positive regulation of dendritic spine development	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of dendritic spine development	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of dendritic spine development	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of muscle cell differentiation	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of muscle cell differentiation	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of neuron projection development	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of neuron projection development	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of neuron projection development	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of protein export from nucleus	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within positive regulation of protein export from nucleus	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of protein export from nucleus	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of synapse structural plasticity	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of synapse structural plasticity	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of synapse structural plasticity	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of syncytium formation by plasma membrane fusion	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of syncytium formation by plasma membrane fusion	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of transcription by RNA polymerase II	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of transcription by RNA polymerase II	ISO Inferred from Sequence Orthology more info
involved_in regulation of muscle cell differentiation	ISO Inferred from Sequence Orthology more info
involved_in regulation of muscle cell differentiation	ISS Inferred from Sequence or Structural Similarity more info
involved_in regulation of protein localization	ISO Inferred from Sequence Orthology more info
involved_in regulation of protein localization	ISS Inferred from Sequence or Structural Similarity more info
involved_in regulation of synapse organization	IDA Inferred from Direct Assay more info	PubMed
involved_in regulation of synapse organization	IEP Inferred from Expression Pattern more info	PubMed
involved_in regulation of synapse organization	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within signal transduction	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
located_in cytosol	TAS Traceable Author Statement more info
is_active_in glutamatergic synapse	IDA Inferred from Direct Assay more info	PubMed
is_active_in intracellular anatomical structure	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleus	IEA Inferred from Electronic Annotation more info
is_active_in postsynaptic density	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: calcium/calmodulin-dependent protein kinase type 1

Names: G alpha interacting protein; caM kinase I alpha; caM-KI; caMKI-alpha; regulator of G-protein signalling 19

NP_604463.1

EC 2.7.11.17

XP_006237063.1

EC 2.7.11.17

XP_038962912.1

EC 2.7.11.17

XP_038962913.1

EC 2.7.11.17

XP_063141528.1

EC 2.7.11.17

XP_063141529.1

EC 2.7.11.17

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_134468.2 → NP_604463.1 calcium/calmodulin-dependent protein kinase type 1

See identical proteins and their annotated locations for NP_604463.1

Status: PROVISIONAL

Source sequence(s)

JAXUCZ010000004

UniProtKB/Swiss-Prot

Q63084, Q63450

UniProtKB/TrEMBL

A0A8I6B458, A6IBQ6

Conserved Domains (1) summary

cd14167
Location:16 → 278

STKc_CaMKI_alpha; Catalytic domain of the Serine/Threonine kinase, Calcium/calmodulin-dependent protein kinase Type I alpha

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086022.1 Reference GRCr8

Range

148036843..148047675 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_063285458.1 → XP_063141528.1 calcium/calmodulin-dependent protein kinase type 1 isoform X2

UniProtKB/TrEMBL

A0A8I6B458
XM_039106984.2 → XP_038962912.1 calcium/calmodulin-dependent protein kinase type 1 isoform X1

UniProtKB/TrEMBL

A0A8I6B458

Conserved Domains (1) summary

cd14167
Location:47 → 309

STKc_CaMKI_alpha; Catalytic domain of the Serine/Threonine kinase, Calcium/calmodulin-dependent protein kinase Type I alpha
XM_006237001.5 → XP_006237063.1 calcium/calmodulin-dependent protein kinase type 1 isoform X4

See identical proteins and their annotated locations for XP_006237063.1

UniProtKB/TrEMBL

A0A8I6AEY2, A0A8I6B458

Related

ENSRNOP00000091265.1, ENSRNOT00000093950.2

Conserved Domains (2) summary

smart00220
Location:20 → 276

S_TKc; Serine/Threonine protein kinases, catalytic domain

cd14167
Location:16 → 278

STKc_CaMKI_alpha; Catalytic domain of the Serine/Threonine kinase, Calcium/calmodulin-dependent protein kinase Type I alpha
XM_063285459.1 → XP_063141529.1 calcium/calmodulin-dependent protein kinase type 1 isoform X3

UniProtKB/TrEMBL

A0A8I6B458, A0A8L2UL04
XM_039106985.2 → XP_038962913.1 calcium/calmodulin-dependent protein kinase type 1 isoform X3

UniProtKB/TrEMBL

A0A8I6B458, A0A8L2UL04

Related

ENSRNOP00000033456.5, ENSRNOT00000029728.7

Conserved Domains (1) summary

cd14167
Location:47 → 309

STKc_CaMKI_alpha; Catalytic domain of the Serine/Threonine kinase, Calcium/calmodulin-dependent protein kinase Type I alpha