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Apobr apolipoprotein B receptor [ Mus musculus (house mouse) ]

Gene ID: 171504, updated on 9-Dec-2024

Summary

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Official Symbol
Apobrprovided by MGI
Official Full Name
apolipoprotein B receptorprovided by MGI
Primary source
MGI:MGI:2176230
See related
Ensembl:ENSMUSG00000042759 AllianceGenome:MGI:2176230
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Apob48r; Apob-48r
Summary
Enables very-low-density lipoprotein particle receptor activity. Acts upstream of or within triglyceride metabolic process. Predicted to be located in plasma membrane. Predicted to be part of chylomicron; low-density lipoprotein particle; and very-low-density lipoprotein particle. Orthologous to human APOBR (apolipoprotein B receptor). [provided by Alliance of Genome Resources, Dec 2024]
Expression
Broad expression in placenta adult (RPKM 11.1), genital fat pad adult (RPKM 7.1) and 15 other tissues See more
Orthologs
human all
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Genomic context

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See Apobr in Genome Data Viewer
Location:
7 F3; 7 69.17 cM
Exon count:
4
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 7 NC_000073.7 (126184092..126188297)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 7 NC_000073.6 (126584918..126589125)

Chromosome 7 - NC_000073.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 25579 Neighboring gene CLN3 lysosomal/endosomal transmembrane protein, battenin Neighboring gene CapStarr-seq enhancer MGSCv37_chr7:133726956-133727139 Neighboring gene microRNA 7059 Neighboring gene interleukin 27 Neighboring gene predicted gene, 39086 Neighboring gene predicted gene, 39087 Neighboring gene nuclear protein transcription regulator 1

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. The murine macrophage apoB-48 receptor gene (Apob-48r): homology to the human receptor. Brown ML, et al. J Lipid Res, 2002 Aug. PMID 12177162
  2. WDFY4 is required for cross-presentation in response to viral and tumor antigens. Theisen DJ, et al. Science, 2018 Nov 9. PMID 30409884, Free PMC Article
  3. BioID screening of biotinylation sites using the avidin-like protein Tamavidin 2-REV identifies global interactors of stimulator of interferon genes (STING). Motani K, et al. J Biol Chem, 2020 Aug 7. PMID 32554809, Free PMC Article
  4. Large-scale gene trapping in C57BL/6N mouse embryonic stem cells. Hansen GM, et al. Genome Res, 2008 Oct. PMID 18799693, Free PMC Article
  5. Genetic determinants of micronucleus formation in vivo. Adams DJ, et al. Nature, 2024 Mar. PMID 38355793, Free PMC Article

See all (15) citations in PubMed

GeneRIFs: Gene References Into Functions

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (1) 

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables very-low-density lipoprotein particle receptor activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables very-low-density lipoprotein particle receptor activity IDA
Inferred from Direct Assay
more info
 PubMed 
Process Evidence Code Pubs
involved_in cholesterol metabolic process IEA
Inferred from Electronic Annotation
more info
  
involved_in lipid transport IEA
Inferred from Electronic Annotation
more info
  
involved_in triglyceride metabolic process IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within triglyceride metabolic process IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in vesicle-mediated transport IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
part_of chylomicron IEA
Inferred from Electronic Annotation
more info
  
part_of low-density lipoprotein particle IEA
Inferred from Electronic Annotation
more info
  
located_in plasma membrane IEA
Inferred from Electronic Annotation
more info
  
part_of very-low-density lipoprotein particle IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
apolipoprotein B receptor
Names
apolipoprotein B-100 receptor
apolipoprotein B-48 receptor
apolipoprotein B48 receptor

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_138310.1 → NP_612183.1  apolipoprotein B receptor

    See identical proteins and their annotated locations for NP_612183.1

    Status: PROVISIONAL

    Source sequence(s)
    AF141335
    Consensus CDS
    CCDS21834.1
    UniProtKB/Swiss-Prot
    Q8VBT6
    Related
    ENSMUSP00000042028.7, ENSMUST00000039522.8
    Conserved Domains (2) summary
    PTZ00121
    Location:32 → 475
    PTZ00121; MAEBL; Provisional
    TIGR00927
    Location:503 → 804
    2A1904; K+-dependent Na+/Ca+ exchanger

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000073.7 Reference GRCm39 C57BL/6J

    Range
    126184092..126188297
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_036152727.1 → XP_036008620.1  apolipoprotein B receptor isoform X1

    Conserved Domains (2) summary
    PTZ00121
    Location:32 → 475
    PTZ00121; MAEBL; Provisional
    TIGR00927
    Location:503 → 804
    2A1904; K+-dependent Na+/Ca+ exchanger

  2. XM_006507399.5 → XP_006507462.1  apolipoprotein B receptor isoform X3

    Conserved Domains (1) summary
    PTZ00121
    Location:32 → 475
    PTZ00121; MAEBL; Provisional

  3. XM_036152728.1 → XP_036008621.1  apolipoprotein B receptor isoform X2

    Conserved Domains (1) summary
    PTZ00121
    Location:32 → 475
    PTZ00121; MAEBL; Provisional

  4. XM_036152729.1 → XP_036008622.1  apolipoprotein B receptor isoform X4

  5. XM_036152730.1 → XP_036008623.1  apolipoprotein B receptor isoform X5

Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q8VBT6.1 GenPept UniProtKB/Swiss-Prot:Q8VBT6

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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