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Cyp2c13 cytochrome P450, family 2, subfamily c, polypeptide 13 [ Rattus norvegicus (Norway rat) ]

Gene ID: 171521, updated on 17-Aug-2024

Summary

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Symbol
Cyp2c13provided by RGD
Full Name
cytochrome P450, family 2, subfamily c, polypeptide 13provided by RGD
Primary source
RGD:620363
See related
EnsemblRapid:ENSRNOG00000049464 AllianceGenome:RGD:620363
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
Cyp2c38
Summary
Predicted to enable heme binding activity and monooxygenase activity. Predicted to be involved in epoxygenase P450 pathway and xenobiotic metabolic process. Predicted to be located in endoplasmic reticulum membrane. Predicted to be active in cytoplasm and intracellular membrane-bounded organelle. Human ortholog(s) of this gene implicated in end stage renal disease and renal hypertension. Orthologous to human CYP2C8 (cytochrome P450 family 2 subfamily C member 8). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Restricted expression toward (RPKM 2978.9) See more
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Genomic context

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Location:
1q53
Exon count:
14
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 1 NC_086019.1 (248706787..248787239, complement)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 1 NC_051336.1 (238786764..238867195, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 1 NC_005100.4 (258796624..258877023, complement)

Chromosome 1 - NC_086019.1Genomic Context describing neighboring genes Neighboring gene igE-binding protein-like Neighboring gene cytochrome P450, family 2, subfamily c, polypeptide 12 Neighboring gene uncharacterized LOC134485236 Neighboring gene U6 spliceosomal RNA

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Characterization of a cDNA for rat P-450g, a highly polymorphic, male-specific cytochrome in the P-450IIC subfamily. McClellan-Green PD, et al. Biochemistry, 1989 Jul 11. PMID 2775738
  2. Characterization of a cDNA for the unexpressed form of cytochrome P-450g from the (-g) rat and differentiation of its mRNA from that of the (+g) phenotype using specific oligoprobes. Yeowell HN, et al. Biochemistry, 1990 Jan 23. PMID 2337591
  3. Structural and regulatory analysis of the male-specific rat liver cytochrome P-450 g: repression by continuous growth hormone administration. Zaphiropoulos PG, et al. Mol Endocrinol, 1990 Jan. PMID 2325668
  4. Gene structure and expression of the rat cytochrome P450IIC13, a polymorphic, male-specific cytochrome in the P450IIC subfamily. Eguchi H, et al. Biochemistry, 1991 Nov 12. PMID 1834171
  5. Purification and characterization of three male-specific and one female-specific forms of cytochrome P-450 from rat liver microsomes. Matsumoto T, et al. J Biochem, 1986 Nov. PMID 2434473

See all (7) citations in PubMed

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Clone Names

  • MGC114253

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables arachidonic acid epoxygenase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables aromatase activity IEA
Inferred from Electronic Annotation
more info
  
enables heme binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables heme binding IEA
Inferred from Electronic Annotation
more info
  
enables iron ion binding IEA
Inferred from Electronic Annotation
more info
  
enables monooxygenase activity IEA
Inferred from Electronic Annotation
more info
  
enables monooxygenase activity TAS
Traceable Author Statement
more info
 PubMed 
enables oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen IEA
Inferred from Electronic Annotation
more info
  
enables oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in epoxygenase P450 pathway IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in xenobiotic metabolic process IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in endoplasmic reticulum IEA
Inferred from Electronic Annotation
more info
  
located_in endoplasmic reticulum membrane IEA
Inferred from Electronic Annotation
more info
  
is_active_in intracellular membrane-bounded organelle IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
cytochrome P450 2C13, male-specific
Names
CYP2C13 (+)
CYPIIC13
P-450g
P450-G
UT-5
cytochrome P-450g
cytochrome P450 2C13, male-specific-like
cytochrome P450 g (+)
cytochrome P450, 2c38
cytochrome P450-G
cytochrome P450-UT-5
NP_612523.1
XP_038946817.1
XP_038946856.1
XP_038946894.1
XP_063133702.1
XP_063133714.1
XP_063133724.1
XP_063133732.1
XP_063133747.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_138514.1 → NP_612523.1  cytochrome P450 2C13, male-specific

    See identical proteins and their annotated locations for NP_612523.1

    Status: PROVISIONAL

    Source sequence(s)
    M32277
    UniProtKB/Swiss-Prot
    P20814, P22693, Q64587
    UniProtKB/TrEMBL
    M0RD38, Q5I0P5
    Related
    ENSRNOP00000067531.1, ENSRNOT00000071633.5
    Conserved Domains (1) summary
    pfam00067
    Location:30 → 487
    p450; Cytochrome P450

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086019.1 Reference GRCr8

    Range
    248706787..248787239 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_063277632.1 → XP_063133702.1  cytochrome P450 2C13, male-specific isoform X1

    UniProtKB/TrEMBL
    A0A8I5ZKW5

  2. XM_063277644.1 → XP_063133714.1  cytochrome P450 2C13, male-specific isoform X2

    UniProtKB/TrEMBL
    A0A8I5ZKW5

  3. XM_039090889.2 → XP_038946817.1  cytochrome P450 2C13, male-specific isoform X4

    UniProtKB/TrEMBL
    A0A8I5ZKW5
    Conserved Domains (1) summary
    cd20665
    Location:61 → 431
    CYP2C-like; cytochrome P450 family 2, subfamily C, and similar cytochrome P450s

  4. XM_063277654.1 → XP_063133724.1  cytochrome P450 2C13, male-specific isoform X3

    UniProtKB/TrEMBL
    A0A8I5ZKW5
    Related
    ENSRNOP00000078469.1, ENSRNOT00000118870.2

  5. XM_063277662.1 → XP_063133732.1  cytochrome P450 2C13, male-specific isoform X3

    UniProtKB/TrEMBL
    A0A8I5ZKW5

  6. XM_063277677.1 → XP_063133747.1  cytochrome P450 2C13, male-specific isoform X5

  7. XM_039090966.2 → XP_038946894.1  cytochrome P450 2C13, male-specific isoform X7

    Conserved Domains (1) summary
    cl41757
    Location:61 → 273
    cytochrome_P450; cytochrome P450 (CYP) superfamily

  8. XM_039090928.2 → XP_038946856.1  cytochrome P450 2C13, male-specific isoform X6

    Conserved Domains (1) summary
    cl41757
    Location:61 → 281
    cytochrome_P450; cytochrome P450 (CYP) superfamily
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P20814.1 GenPept UniProtKB/Swiss-Prot:P20814

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