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Matk megakaryocyte-associated tyrosine kinase [ Mus musculus (house mouse) ]

Gene ID: 17179, updated on 9-Dec-2024

Summary

Official Symbol
Matkprovided by MGI
Official Full Name
megakaryocyte-associated tyrosine kinaseprovided by MGI
Primary source
MGI:MGI:99259
See related
Ensembl:ENSMUSG00000004933 AllianceGenome:MGI:99259
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
CHK; HYL; Ntk; p56ntk
Summary
Predicted to enable non-membrane spanning protein tyrosine kinase activity. Predicted to be involved in protein phosphorylation. Predicted to be located in cytoplasm and membrane. Predicted to be active in plasma membrane. Is expressed in brain; gonad; hemolymphoid system gland; and intestine. Orthologous to human MATK (megakaryocyte-associated tyrosine kinase). [provided by Alliance of Genome Resources, Dec 2024]
Expression
Biased expression in cortex adult (RPKM 63.6), frontal lobe adult (RPKM 48.8) and 6 other tissues See more
Orthologs
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Genomic context

See Matk in Genome Data Viewer
Location:
10 39.72 cM; 10 C1
Exon count:
18
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 10 NC_000076.7 (81088769..81098819)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 10 NC_000076.6 (81252935..81262985)

Chromosome 10 - NC_000076.7Genomic Context describing neighboring genes Neighboring gene ataxia, cerebellar, Cayman type, opposite strand Neighboring gene ataxia, cerebellar, Cayman type Neighboring gene zinc finger RNA binding protein 2 Neighboring gene STARR-positive B cell enhancer ABC_E6886 Neighboring gene mitochondrial ribosomal protein L54 Neighboring gene amyloid beta precursor protein binding family A member 3 Neighboring gene microRNA 3057

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (2) 
  • Gene trapped (1) 
  • Targeted (3)  1 citation

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Clone Names

  • MGC130505

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
 
enables histone H2AXY142 kinase activity IEA
Inferred from Electronic Annotation
more info
 
enables histone H3Y41 kinase activity IEA
Inferred from Electronic Annotation
more info
 
enables non-membrane spanning protein tyrosine kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
 
enables non-membrane spanning protein tyrosine kinase activity IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
involved_in chromatin remodeling IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
 
located_in membrane IEA
Inferred from Electronic Annotation
more info
 
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
 

General protein information

Preferred Names
megakaryocyte-associated tyrosine-protein kinase
Names
Csk homologous kinase
protein kinase NTK
tyrosine protein kinase
tyrosine-protein kinase CTK
NP_001272782.1
NP_001272783.1
NP_001272784.1
NP_034898.1
XP_006513357.1
XP_006513358.1
XP_006513361.1
XP_006513362.1
XP_011241678.1
XP_011241679.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001285853.2NP_001272782.1  megakaryocyte-associated tyrosine-protein kinase isoform 2

    See identical proteins and their annotated locations for NP_001272782.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) contains a distinct 5' UTR, lacks an in-frame portion of the 5' coding region and uses an alternate in-frame splice site in the 5' coding region, compared to variant 1. The resulting isoform (2) has a shorter N-terminus, compared to isoform 1. Variants 2 and 6 both encode the same isoform (2).
    Source sequence(s)
    AC155932
    Consensus CDS
    CCDS70077.1
    UniProtKB/TrEMBL
    D3Z4T5, P70223, Q9D6H7
    Related
    ENSMUSP00000113043.2, ENSMUST00000121205.8
    Conserved Domains (3) summary
    cd09937
    Location:77174
    SH2_csk_like; Src homology 2 (SH2) domain found in Carboxyl-Terminal Src Kinase (Csk)
    cl17036
    Location:967
    SH3; Src Homology 3 domain superfamily
    cl21453
    Location:187440
    PKc_like; Protein Kinases, catalytic domain
  2. NM_001285854.2NP_001272783.1  megakaryocyte-associated tyrosine-protein kinase isoform 3

    See identical proteins and their annotated locations for NP_001272783.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) contains a distinct 5' UTR and lacks an in-frame portion of the 5' coding region, compared to variant 1. The resulting isoform (3) has a shorter N-terminus, compared to isoform 1. Variants 3, 4, and 7 all encode the same isoform (3).
    Source sequence(s)
    AC155932
    Consensus CDS
    CCDS70078.1
    UniProtKB/TrEMBL
    A0A0R4J1P8, P70223, Q9D6H7
    Related
    ENSMUSP00000100965.4, ENSMUST00000105328.10
    Conserved Domains (3) summary
    cd09937
    Location:76173
    SH2_csk_like; Src homology 2 (SH2) domain found in Carboxyl-Terminal Src Kinase (Csk)
    cl17036
    Location:866
    SH3; Src Homology 3 domain superfamily
    cl21453
    Location:186439
    PKc_like; Protein Kinases, catalytic domain
  3. NM_001285855.2NP_001272784.1  megakaryocyte-associated tyrosine-protein kinase isoform 3

    See identical proteins and their annotated locations for NP_001272784.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (4) contains an alternate exon in the 5' UTR, lacks a portion of the 5' coding region, and initiates translation at an alternate start codon, compared to variant 1. The encoded isoform (3) has a distinct N-terminus and is shorter than isoform 1. Variants 3, 4, and 7 all encode the same isoform (3).
    Source sequence(s)
    AC155932
    Consensus CDS
    CCDS70078.1
    UniProtKB/TrEMBL
    A0A0R4J1P8, P70223, Q9D6H7
    Related
    ENSMUSP00000113576.2, ENSMUST00000119547.8
    Conserved Domains (3) summary
    cd09937
    Location:76173
    SH2_csk_like; Src homology 2 (SH2) domain found in Carboxyl-Terminal Src Kinase (Csk)
    cl17036
    Location:866
    SH3; Src Homology 3 domain superfamily
    cl21453
    Location:186439
    PKc_like; Protein Kinases, catalytic domain
  4. NM_001428580.1NP_001415509.1  megakaryocyte-associated tyrosine-protein kinase isoform 1

    Status: VALIDATED

    Source sequence(s)
    AC155932
    UniProtKB/Swiss-Prot
    P41242, Q6LE90
    UniProtKB/TrEMBL
    A0A0R4J1N6
  5. NM_001428581.1NP_001415510.1  megakaryocyte-associated tyrosine-protein kinase isoform 2

    Status: VALIDATED

    Source sequence(s)
    AC155932
    UniProtKB/TrEMBL
    D3Z4T5, P70223, Q9D6H7
  6. NM_001428582.1NP_001415511.1  megakaryocyte-associated tyrosine-protein kinase isoform 3

    Status: VALIDATED

    Source sequence(s)
    AC155932
    UniProtKB/TrEMBL
    A0A0R4J1P8, P70223, Q9D6H7
  7. NM_010768.3NP_034898.1  megakaryocyte-associated tyrosine-protein kinase isoform 1

    See identical proteins and their annotated locations for NP_034898.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) encodes the longest isoform (1). Variants 1 and 5 both encode the same isoform (1).
    Source sequence(s)
    AC155932
    Consensus CDS
    CCDS24048.1
    UniProtKB/Swiss-Prot
    P41242, Q6LE90
    UniProtKB/TrEMBL
    A0A0R4J1N6
    Related
    ENSMUSP00000113221.2, ENSMUST00000117488.8
    Conserved Domains (3) summary
    cd09937
    Location:116213
    SH2_csk_like; Src homology 2 (SH2) domain found in Carboxyl-Terminal Src Kinase (Csk)
    cl17036
    Location:48106
    SH3; Src Homology 3 domain superfamily
    cl21453
    Location:226479
    PKc_like; Protein Kinases, catalytic domain

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000076.7 Reference GRCm39 C57BL/6J

    Range
    81088769..81098819
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006513298.4XP_006513361.1  megakaryocyte-associated tyrosine-protein kinase isoform X5

    Related
    ENSMUSP00000113666.2, ENSMUST00000120265.2
    Conserved Domains (3) summary
    cd09937
    Location:77174
    SH2_csk_like; Src homology 2 (SH2) domain found in Carboxyl-Terminal Src Kinase (Csk)
    cl17036
    Location:967
    SH3; Src Homology 3 domain superfamily
    cl21453
    Location:187440
    PKc_like; Protein Kinases, catalytic domain
  2. XM_011243376.3XP_011241678.1  megakaryocyte-associated tyrosine-protein kinase isoform X3

    UniProtKB/TrEMBL
    P70223, Q9D6H7
    Conserved Domains (3) summary
    cd09937
    Location:103200
    SH2_csk_like; Src homology 2 (SH2) domain found in Carboxyl-Terminal Src Kinase (Csk)
    cl17036
    Location:3593
    SH3; Src Homology 3 domain superfamily
    cl21453
    Location:213466
    PKc_like; Protein Kinases, catalytic domain
  3. XM_011243377.3XP_011241679.1  megakaryocyte-associated tyrosine-protein kinase isoform X4

    UniProtKB/TrEMBL
    P70223, Q9D6H7
    Conserved Domains (3) summary
    cd09937
    Location:102199
    SH2_csk_like; Src homology 2 (SH2) domain found in Carboxyl-Terminal Src Kinase (Csk)
    cl17036
    Location:3492
    SH3; Src Homology 3 domain superfamily
    cl21453
    Location:212465
    PKc_like; Protein Kinases, catalytic domain
  4. XM_006513299.4XP_006513362.1  megakaryocyte-associated tyrosine-protein kinase isoform X6

    Conserved Domains (3) summary
    cd09937
    Location:76173
    SH2_csk_like; Src homology 2 (SH2) domain found in Carboxyl-Terminal Src Kinase (Csk)
    cl17036
    Location:866
    SH3; Src Homology 3 domain superfamily
    cl21453
    Location:186439
    PKc_like; Protein Kinases, catalytic domain
  5. XM_006513295.5XP_006513358.1  megakaryocyte-associated tyrosine-protein kinase isoform X2

    Conserved Domains (3) summary
    cd09937
    Location:116213
    SH2_csk_like; Src homology 2 (SH2) domain found in Carboxyl-Terminal Src Kinase (Csk)
    cl17036
    Location:48106
    SH3; Src Homology 3 domain superfamily
    cl21453
    Location:226479
    PKc_like; Protein Kinases, catalytic domain
  6. XM_006513294.4XP_006513357.1  megakaryocyte-associated tyrosine-protein kinase isoform X1

    UniProtKB/Swiss-Prot
    P41242, Q6LE90
    Conserved Domains (3) summary
    cd09937
    Location:117214
    SH2_csk_like; Src homology 2 (SH2) domain found in Carboxyl-Terminal Src Kinase (Csk)
    cl17036
    Location:49107
    SH3; Src Homology 3 domain superfamily
    cl21453
    Location:227480
    PKc_like; Protein Kinases, catalytic domain