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HIV2gp8 nef protein [ Human immunodeficiency virus 2 ]

Gene ID: 1724715, updated on 18-Aug-2023

Summary

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Gene symbol
HIV2gp8
Gene description
nef protein
Locus tag
HIV2gp8
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Human immunodeficiency virus 2 (isolate: BEN)
Lineage
Viruses; Retro-transcribing viruses; Retroviridae; Orthoretrovirinae; Lentivirus; Primate lentivirus group
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Genomic context

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Location:
clone: MK[2,6].
Sequence:
NC_001722.1 (9120..9893)

NC_001722.1Genomic Context describing neighboring genes Neighboring gene vpx protein Neighboring gene vpr protein Neighboring gene tat protein Neighboring gene rev protein Neighboring gene env polyprotein

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_001722.1

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Study of the HIV-2 Env cytoplasmic tail variability and its impact on Tat, Rev and Nef. Bakouche N, et al. PLoS One, 2013. PMID 24223892, Free PMC Article
  2. Efficient Nef-mediated downmodulation of TCR-CD3 and CD28 is associated with high CD4+ T cell counts in viremic HIV-2 infection. Khalid M, et al. J Virol, 2012 May. PMID 22345473, Free PMC Article
  3. A novel proviral clone of HIV-2: biological and phylogenetic relationship to other primate immunodeficiency viruses. Kirchhoff F, et al. Virology, 1990 Jul. PMID 2353457
  4. Lentiviral Nef proteins utilize PAK2-mediated deregulation of cofilin as a general strategy to interfere with actin remodeling. Stolp B, et al. J Virol, 2010 Apr. PMID 20147394, Free PMC Article
  5. Human immunodeficiency virus (HIV) type-1, HIV-2 and simian immunodeficiency virus Nef proteins. Laguette N, et al. Mol Aspects Med, 2010 Oct. PMID 20594957

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Data show that the nucleotides responsible for the variability of the env's 3' end cytoplasmic tail (CT) don't impact rev and Nef, but impacted Env and Tat together.
    Title: Study of the HIV-2 Env cytoplasmic tail variability and its impact on Tat, Rev and Nef.
  2. Nef-mediated downmodulation of TCR-CD3 and CD28 help viremic HIV-2-infected individuals to maintain normal CD4(+) T cell homeostasis
    Title: Efficient Nef-mediated downmodulation of TCR-CD3 and CD28 is associated with high CD4+ T cell counts in viremic HIV-2 infection.
  3. This review summarizes common and distinct features among Nef proteins and how they contribute to increasing HIV and SIV fitness towards their respective hosts.
    Title: Human immunodeficiency virus (HIV) type-1, HIV-2 and simian immunodeficiency virus Nef proteins.
  4. These results establish hijacking of PAK2 for deregulation of cofilin and inhibition of triggered actin remodeling as a highly conserved function of lentiviral Nef proteins.
    Title: Lentiviral Nef proteins utilize PAK2-mediated deregulation of cofilin as a general strategy to interfere with actin remodeling.
Submit: New GeneRIF Correction

General gene information

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Homology

General protein information

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Preferred Names
nef protein

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001722.1 Reference assembly

    Range
    9120..9893
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NP_056845.1 nef protein [Human immunodeficiency virus 2]

    See identical proteins and their annotated locations for NP_056845.1

    Status: PROVISIONAL

    UniProtKB/Swiss-Prot
    P18092
    UniProtKB/TrEMBL
    A0A2Z4MTJ6, A0A7D6CKS6
    Conserved Domains (1) summary
    pfam00469
    Location:2 → 235
    F-protein; Negative factor, (F-Protein) or Nef
Nucleotide Protein
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