U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Mgat3 mannoside acetylglucosaminyltransferase 3 [ Mus musculus (house mouse) ]

Gene ID: 17309, updated on 9-Aug-2024

Summary

Go to the top of the page Help
Official Symbol
Mgat3provided by MGI
Official Full Name
mannoside acetylglucosaminyltransferase 3provided by MGI
Primary source
MGI:MGI:104532
See related
Ensembl:ENSMUSG00000042428 AllianceGenome:MGI:104532
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
GnT-III; 1110038J12Rik
Summary
Enables beta-1,4-mannosylglycoprotein 4-beta-N-acetylglucosaminyltransferase activity. Acts upstream of or within several processes, including amyloid-beta metabolic process; negative regulation of lysosomal protein catabolic process; and positive regulation of protein localization to early endosome. Is expressed in several structures, including alimentary system; metanephros; and nervous system. Orthologous to human MGAT3 (beta-1,4-mannosyl-glycoprotein 4-beta-N-acetylglucosaminyltransferase). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Broad expression in colon adult (RPKM 15.5), kidney adult (RPKM 14.4) and 22 other tissues See more
Orthologs
human all
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

Go to the top of the page Help
See Mgat3 in Genome Data Viewer
Location:
15 E1; 15 37.85 cM
Exon count:
8
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 15 NC_000081.7 (80057852..80099720)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 15 NC_000081.6 (80173651..80215519)

Chromosome 15 - NC_000081.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 31134 Neighboring gene synaptogyrin 1 Neighboring gene STARR-seq mESC enhancer starr_39220 Neighboring gene STARR-seq mESC enhancer starr_39222 Neighboring gene STARR-positive B cell enhancer ABC_E10868 Neighboring gene predicted gene, 31253 Neighboring gene STARR-seq mESC enhancer starr_39224 Neighboring gene TGF-beta activated kinase 1/MAP3K7 binding protein 1 Neighboring gene STARR-seq mESC enhancer starr_39229 Neighboring gene STARR-seq mESC enhancer starr_39231 Neighboring gene predicted gene, 46521 Neighboring gene ribosomal protein S2 pseudogene Neighboring gene mitochondrial elongation factor 1

Genomic regions, transcripts, and products

Go to the top of the page Help

Go to nucleotide: Graphics FASTA GenBank

Expression

Go to the top of the page Help
  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

Go to the top of the pageHelp

Related articles in PubMed

  1. Bisected, complex N-glycans and galectins in mouse mammary tumor progression and human breast cancer. Miwa HE, et al. Glycobiology, 2013 Dec. PMID 24037315, Free PMC Article
  2. Loss and recovery of Mgat3 and GnT-III Mediated E-cadherin N-glycosylation is a mechanism involved in epithelial-mesenchymal-epithelial transitions. Pinho SS, et al. PLoS One, 2012. PMID 22427986, Free PMC Article
  3. Wnt/beta-catenin signaling down-regulates N-acetylglucosaminyltransferase III expression: the implications of two mutually exclusive pathways for regulation. Xu Q, et al. J Biol Chem, 2011 Feb 11. PMID 21115490, Free PMC Article
  4. The bisecting GlcNAc on N-glycans inhibits growth factor signaling and retards mammary tumor progression. Song Y, et al. Cancer Res, 2010 Apr 15. PMID 20395209, Free PMC Article
  5. Cell-cell interaction-dependent regulation of N-acetylglucosaminyltransferase III and the bisected N-glycans in GE11 epithelial cells. Involvement of E-cadherin-mediated cell adhesion. Iijima J, et al. J Biol Chem, 2006 May 12. PMID 16537539

See all (39) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. MiR-23a transcriptional activated by Runx2 increases metastatic potential of mouse hepatoma cell via directly targeting Mgat3
    Title: MiR-23a transcriptional activated by Runx2 increases metastatic potential of mouse hepatoma cell via directly targeting Mgat3.
  2. The MGAT3 and bisected complex N-glycans retard mouse mammary tumor progression; identification of key galectins that promote mammary tumor progression in mice is not straightforward because the galectin genes are expressed; and high levels of MGAT3.
    Title: Bisected, complex N-glycans and galectins in mouse mammary tumor progression and human breast cancer.
  3. data suggest that Fut8(-/-) mice adapted to oxidative stress, both ex vivo and in vivo, by inducing various genes including GnT-III, which may compensate for the loss of core fucose functions
    Title: The absence of core fucose up-regulates GnT-III and Wnt target genes: a possible mechanism for an adaptive response in terms of glycan function.
  4. Mgat3 glycogene expression and GnT-III-mediated glycosylation, specifically on E-cadherin, is a novel and major component of the Epithelial-Mesenchymal-Transition and the reverted process, Mesenchymal-Epithelial-Transition mechanism.
    Title: Loss and recovery of Mgat3 and GnT-III Mediated E-cadherin N-glycosylation is a mechanism involved in epithelial-mesenchymal-epithelial transitions.
  5. Roles of N-acetylglucosaminyltransferase III in epithelial-to-mesenchymal transition induced by transforming growth factor beta1 (TGF-beta1) in epithelial cell lines
    Title: Roles of N-acetylglucosaminyltransferase III in epithelial-to-mesenchymal transition induced by transforming growth factor β1 (TGF-β1) in epithelial cell lines.
  6. GnT-III expression may be precisely regulated by the interplay of E-cadherin-catenin complex-mediated cell-cell adhesion and Wnt/beta-catenin signaling
    Title: Wnt/beta-catenin signaling down-regulates N-acetylglucosaminyltransferase III expression: the implications of two mutually exclusive pathways for regulation.
  7. upregulation of GnT-III in AD brains may represent an adaptive response to protect them from additional beta-amyloid production
    Title: Protective effect of N-glycan bisecting GlcNAc residues on beta-amyloid production in Alzheimer's disease.
  8. beta1,4-N-acetylglucosaminyltransferase III inhibits the function of alpha5beta1 integrin
    Title: Introduction of bisecting GlcNAc into integrin alpha5beta1 reduces ligand binding and down-regulates cell adhesion and cell migration.
  9. mice homozygous for the Mgat3T37 mutation that express truncated GlcNAc-TIII from two mutant alleles suffer neurological and other consequences
    Title: Truncated, inactive N-acetylglucosaminyltransferase III (GlcNAc-TIII) induces neurological and other traits absent in mice that lack GlcNAc-TIII.
  10. An E-cadherin-dependent pathway plays a critical role in regulation of GnT-III expression; changes in GnT-III expression presumably contribute to intracellular signaling transduction during tissue development and homeostasis.
    Title: Cell-cell interaction-dependent regulation of N-acetylglucosaminyltransferase III and the bisected N-glycans in GE11 epithelial cells. Involvement of E-cadherin-mediated cell adhesion.
Submit: New GeneRIF Correction

Variation

Go to the top of the page Help

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (1) 
  • Targeted (2)  1 citation

General gene information

Go to the top of the page Help

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables beta-1,4-mannosylglycoprotein 4-beta-N-acetylglucosaminyltransferase activity IMP
Inferred from Mutant Phenotype
more info
 PubMed 
enables beta-1,4-mannosylglycoprotein 4-beta-N-acetylglucosaminyltransferase activity ISO
Inferred from Sequence Orthology
more info
  
enables glycosyltransferase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables glycosyltransferase activity IDA
Inferred from Direct Assay
more info
 PubMed 
Process Evidence Code Pubs
involved_in N-acetylglucosamine metabolic process IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within N-acetylglucosamine metabolic process IDA
Inferred from Direct Assay
more info
 PubMed 
acts_upstream_of_or_within amyloid-beta metabolic process IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within cellular response to oxidative stress IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within cognition IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of lysosomal protein catabolic process IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within negative regulation of lysosomal protein catabolic process IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within positive regulation of protein localization to early endosome IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within protein N-linked glycosylation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in protein localization ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of protein localization to early endosome IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in regulation of cell migration ISO
Inferred from Sequence Orthology
more info
  

General protein information

Go to the top of the page Help
Preferred Names
beta-1,4-mannosyl-glycoprotein 4-beta-N-acetylglucosaminyltransferase
Names
N-glycosyl-oligosaccharide-glycoprotein N-acetylglucosaminyltransferase III
glcNAc-T III
NP_034925.2
XP_006520616.1
XP_006520617.1
XP_006520618.1
XP_006520619.1
XP_006520620.1
XP_011243787.1

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_010795.4 → NP_034925.2  beta-1,4-mannosyl-glycoprotein 4-beta-N-acetylglucosaminyltransferase

    See identical proteins and their annotated locations for NP_034925.2

    Status: VALIDATED

    Source sequence(s)
    BC053040, CJ174488
    Consensus CDS
    CCDS27660.1
    UniProtKB/Swiss-Prot
    P70386, Q10470
    UniProtKB/TrEMBL
    Q5RKT9
    Related
    ENSMUSP00000043077.7, ENSMUST00000044970.7
    Conserved Domains (1) summary
    pfam04724
    Location:205 → 502
    Glyco_transf_17; Glycosyltransferase family 17

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000081.7 Reference GRCm39 C57BL/6J

    Range
    80057852..80099720
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011245485.2 → XP_011243787.1  beta-1,4-mannosyl-glycoprotein 4-beta-N-acetylglucosaminyltransferase isoform X2

    See identical proteins and their annotated locations for XP_011243787.1

    UniProtKB/Swiss-Prot
    P70386, Q10470
    UniProtKB/TrEMBL
    Q5RKT9
    Conserved Domains (1) summary
    pfam04724
    Location:205 → 502
    Glyco_transf_17; Glycosyltransferase family 17

  2. XM_006520556.5 → XP_006520619.1  beta-1,4-mannosyl-glycoprotein 4-beta-N-acetylglucosaminyltransferase isoform X2

    See identical proteins and their annotated locations for XP_006520619.1

    UniProtKB/Swiss-Prot
    P70386, Q10470
    UniProtKB/TrEMBL
    Q5RKT9
    Conserved Domains (1) summary
    pfam04724
    Location:205 → 502
    Glyco_transf_17; Glycosyltransferase family 17

  3. XM_006520555.2 → XP_006520618.1  beta-1,4-mannosyl-glycoprotein 4-beta-N-acetylglucosaminyltransferase isoform X2

    See identical proteins and their annotated locations for XP_006520618.1

    UniProtKB/Swiss-Prot
    P70386, Q10470
    UniProtKB/TrEMBL
    Q5RKT9
    Conserved Domains (1) summary
    pfam04724
    Location:205 → 502
    Glyco_transf_17; Glycosyltransferase family 17

  4. XM_006520553.2 → XP_006520616.1  beta-1,4-mannosyl-glycoprotein 4-beta-N-acetylglucosaminyltransferase isoform X1

    UniProtKB/Swiss-Prot
    P70386, Q10470
    Conserved Domains (1) summary
    pfam04724
    Location:213 → 510
    Glyco_transf_17; Glycosyltransferase family 17

  5. XM_006520557.5 → XP_006520620.1  beta-1,4-mannosyl-glycoprotein 4-beta-N-acetylglucosaminyltransferase isoform X2

    See identical proteins and their annotated locations for XP_006520620.1

    UniProtKB/Swiss-Prot
    P70386, Q10470
    UniProtKB/TrEMBL
    Q5RKT9
    Conserved Domains (1) summary
    pfam04724
    Location:205 → 502
    Glyco_transf_17; Glycosyltransferase family 17

  6. XM_006520554.5 → XP_006520617.1  beta-1,4-mannosyl-glycoprotein 4-beta-N-acetylglucosaminyltransferase isoform X2

    See identical proteins and their annotated locations for XP_006520617.1

    UniProtKB/Swiss-Prot
    P70386, Q10470
    UniProtKB/TrEMBL
    Q5RKT9
    Conserved Domains (1) summary
    pfam04724
    Location:205 → 502
    Glyco_transf_17; Glycosyltransferase family 17

RNA

  1. XR_004938806.1 RNA Sequence

  2. XR_004938807.1 RNA Sequence

Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q10470.2 GenPept UniProtKB/Swiss-Prot:Q10470

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

Chemical Information
Molecular Biology Databases
Research Materials
Tools