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Mras muscle and microspikes RAS [ Mus musculus (house mouse) ]

Gene ID: 17532, updated on 9-Dec-2024

Summary

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Official Symbol
Mrasprovided by MGI
Official Full Name
muscle and microspikes RASprovided by MGI
Primary source
MGI:MGI:1100856
See related
Ensembl:ENSMUSG00000032470 AllianceGenome:MGI:1100856
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
2900078C09Rik
Summary
Predicted to enable GTP-dependent protein binding activity; GTPase activity; and guanyl ribonucleotide binding activity. Acts upstream of or within cellular response to leukemia inhibitory factor. Predicted to be active in plasma membrane. Is expressed in several structures, including brain; branchial arch; future spinal cord; limb bud; and liver. Human ortholog(s) of this gene implicated in Noonan syndrome 11. Orthologous to human MRAS (muscle RAS oncogene homolog). [provided by Alliance of Genome Resources, Dec 2024]
Expression
Broad expression in cortex adult (RPKM 34.0), ovary adult (RPKM 30.7) and 21 other tissues See more
Orthologs
human all
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Genomic context

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See Mras in Genome Data Viewer
Location:
9 E3.3; 9 51.63 cM
Exon count:
9
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 9 NC_000075.7 (99267473..99319505, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 9 NC_000075.6 (99385420..99437700, complement)

Chromosome 9 - NC_000075.7Genomic Context describing neighboring genes Neighboring gene centrosomal protein 70 Neighboring gene RIKEN cDNA 4930422M22 gene Neighboring gene DnaJ (Hsp40) homolog, subfamily C, member 14 pseudogene Neighboring gene extended synaptotagmin-like protein 3 Neighboring gene STARR-seq mESC enhancer starr_25024 Neighboring gene predicted gene, 53543 Neighboring gene RIKEN cDNA 1600029I14 gene Neighboring gene STARR-seq mESC enhancer starr_25026 Neighboring gene NME/NM23 family member 9 Neighboring gene armadillo repeat containing 8 Neighboring gene STARR-positive B cell enhancer ABC_E6796

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. M-Ras evolved independently of R-Ras and its neural function is conserved between mammalian and ascidian, which lacks classical Ras. Keduka E, et al. Gene, 2009 Jan 15. PMID 18977283
  2. Critical roles of interactions among switch I-preceding residues and between switch II and its neighboring alpha-helix in conformational dynamics of the GTP-bound Ras family small GTPases. Matsumoto K, et al. J Biol Chem, 2011 Apr 29. PMID 21388959, Free PMC Article
  3. Crystal structure of M-Ras reveals a GTP-bound "off" state conformation of Ras family small GTPases. Ye M, et al. J Biol Chem, 2005 Sep 2. PMID 15994326
  4. Transient recruitment of M-Ras GTPase to phagocytic cups in RAW264 macrophages during FcγR-mediated phagocytosis. Egami Y, et al. Microscopy (Oxf), 2018 Apr 1. PMID 29340604
  5. Multiple aspects of the phenotype of mammary epithelial cells transformed by expression of activated M-Ras depend on an autocrine mechanism mediated by hepatocyte growth factor/scatter factor. Zhang KX, et al. Mol Cancer Res, 2004 Apr. PMID 15140946

See all (44) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. This study demonstrated that M-Ras is recruited to the membrane of phagocytic cups and contributes to the regulation of phagosome formation in macrophages.
    Title: Transient recruitment of M-Ras GTPase to phagocytic cups in RAW264 macrophages during FcγR-mediated phagocytosis.
  2. Expression of the muscarinic M2 and M3 receptors that mediate the cholinergic contractile stimuli of the detrusor muscle was dysregulated in both Mras-/- males and females, although only males exhibited a urinary phenotype.
    Title: Urinary Retention, Incontinence, and Dysregulation of Muscarinic Receptors in Male Mice Lacking Mras.
  3. Overexpression of MRAS in mouse embryonic stem cells leads to different cellular phenotypes.
    Title: MRAS GTPase is a novel stemness marker that impacts mouse embryonic stem cell plasticity and Xenopus embryonic cell fate.
  4. succeed in solving two crystal structures corresponding to state 1 and state 2 from a single Ras polypeptide, M-RasD41E, carrying an H-Ras-type substitution in residue 41
    Title: Critical roles of interactions among switch I-preceding residues and between switch II and its neighboring alpha-helix in conformational dynamics of the GTP-bound Ras family small GTPases.
  5. X-ray crystal structure analyses of a series of mutant H-Ras and M-Ras in complex with guanosine 5'-(beta,gamma-imido)triphosphate (GppNHp), representing various intermediate states of the transition, were determined.
    Title: Structural basis for conformational dynamics of GTP-bound Ras protein.
  6. These results imply that M-Ras, induced and activated by BMP-2 signaling, participates in the osteoblastic determination, differentiation, and transdifferentiation under p38 MAPK and JNK regulation
    Title: M-Ras is activated by bone morphogenetic protein-2 and participates in osteoblastic determination, differentiation, and transdifferentiation.
  7. Conserved expression of Mras was observed in the nervous system both in mice and in ascidians.
    Title: M-Ras evolved independently of R-Ras and its neural function is conserved between mammalian and ascidian, which lacks classical Ras.
  8. These findings proved a crucial role of the cross-talk between two Ras-family GTPases M-Ras and Rap1, mediated by RA-GEF-2, in adhesion signaling.
    Title: The M-Ras-RA-GEF-2-Rap1 pathway mediates tumor necrosis factor-alpha dependent regulation of integrin activation in splenocytes.
  9. Expression of activated mutants of M-Ras was sufficient for oncogenic transformation of a murine mammary epithelial cell line
    Title: Expression of activated M-Ras in a murine mammary epithelial cell line induces epithelial-mesenchymal transition and tumorigenesis.
  10. Data describe the crystal structure of M-Ras in the GDP-bound and guanosine 5'-(beta,gamma-imido)triphosphate (Gpp(NH)p)-bound forms.
    Title: Crystal structure of M-Ras reveals a GTP-bound "off" state conformation of Ras family small GTPases.
Submit: New GeneRIF Correction See all GeneRIFs (12)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (3) 
  • Gene trapped (1)  1 citation

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables G protein activity IEA
Inferred from Electronic Annotation
more info
  
enables GDP binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables GTP binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables GTP binding IEA
Inferred from Electronic Annotation
more info
  
enables GTP-dependent protein binding IEA
Inferred from Electronic Annotation
more info
  
enables GTP-dependent protein binding ISO
Inferred from Sequence Orthology
more info
  
enables GTPase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables GTPase activity ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in Ras protein signal transduction IEA
Inferred from Electronic Annotation
more info
  
involved_in Ras protein signal transduction ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within cellular response to leukemia inhibitory factor IEP
Inferred from Expression Pattern
more info
 PubMed 
Component Evidence Code Pubs
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in plasma membrane IEA
Inferred from Electronic Annotation
more info
  
part_of protein phosphatase type 1 complex IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
ras-related protein M-Ras
Names
X-Ras
ras-related protein R-Ras3
NP_032650.1
XP_006510888.1
XP_030099940.1
XP_036010535.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_008624.3 → NP_032650.1  ras-related protein M-Ras

    See identical proteins and their annotated locations for NP_032650.1

    Status: VALIDATED

    Source sequence(s)
    AB004879, AC157994, AK050469, BC023079, CJ162751, CX122916
    Consensus CDS
    CCDS23433.1
    UniProtKB/Swiss-Prot
    O08989
    UniProtKB/TrEMBL
    Q3TPX5
    Related
    ENSMUSP00000035045.9, ENSMUST00000035045.15
    Conserved Domains (1) summary
    cd04145
    Location:12 → 176
    M_R_Ras_like; R-Ras2/TC21, M-Ras/R-Ras3

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000075.7 Reference GRCm39 C57BL/6J

    Range
    99267473..99319505 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006510825.4 → XP_006510888.1  ras-related protein M-Ras isoform X1

    See identical proteins and their annotated locations for XP_006510888.1

    UniProtKB/Swiss-Prot
    O08989
    UniProtKB/TrEMBL
    Q3TPX5
    Related
    ENSMUSP00000113275.2, ENSMUST00000122384.9
    Conserved Domains (1) summary
    cd04145
    Location:12 → 176
    M_R_Ras_like; R-Ras2/TC21, M-Ras/R-Ras3

  2. XM_036154642.1 → XP_036010535.1  ras-related protein M-Ras isoform X1

    UniProtKB/Swiss-Prot
    O08989
    UniProtKB/TrEMBL
    Q3TPX5
    Related
    ENSMUSP00000112407.2, ENSMUST00000119472.8
    Conserved Domains (1) summary
    cd04145
    Location:12 → 176
    M_R_Ras_like; R-Ras2/TC21, M-Ras/R-Ras3

  3. XM_030244080.1 → XP_030099940.1  ras-related protein M-Ras isoform X1

    UniProtKB/Swiss-Prot
    O08989
    UniProtKB/TrEMBL
    Q3TPX5
    Conserved Domains (1) summary
    cd04145
    Location:12 → 176
    M_R_Ras_like; R-Ras2/TC21, M-Ras/R-Ras3
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
O08989.1 GenPept UniProtKB/Swiss-Prot:O08989

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