mt-Co3 cytochrome c oxidase III, mitochondrial [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: mt-Co3provided by MGI
Official Full Name: cytochrome c oxidase III, mitochondrialprovided by MGI
Primary source: MGI:MGI:102502
See related: AllianceGenome:MGI:102502
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Mus musculus (strain: C57BL/6J)
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: COX3
Summary: Predicted to contribute to cytochrome-c oxidase activity. Predicted to be involved in mitochondrial electron transport, cytochrome c to oxygen and respiratory chain complex IV assembly. Located in mitochondrion. Is expressed in several structures, including alimentary system; brain; heart; integumental system; and sensory organ. Human ortholog(s) of this gene implicated in MELAS syndrome. Orthologous to human MT-CO3 (mitochondrially encoded cytochrome c oxidase III). [provided by Alliance of Genome Resources, Nov 2024]
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Genomic context

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	MT (non-nuclear)	NC_005089.1 (8607..9390)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	MT (non-nuclear)	NC_005089.1 (8607..9390)

Chromosome MT - NC_005089.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

ischemic stress in vivo and oxidative stress in vitro lead to upregulation of COX III, followed by downregulation of COX I expression, impaired COX oxidative activity, and increased apoptosis.
Title: Cytochrome c oxidase III as a mechanism for apoptosis in heart failure following myocardial infarction.

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Spontaneous (2) 1 citation

Pathways from PubChem

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

RH136459 (e-PCR)
- UniSTS:210445

RH125504 (e-PCR)
- UniSTS:162322

RH136484 (e-PCR)
- UniSTS:210468

mt-Co3 (e-PCR), detects polymorphism
- UniSTS:143918

mt-Nd3 (e-PCR), detects polymorphism
- UniSTS:143919

RH136229 (e-PCR)
- UniSTS:210223

RH136241 (e-PCR)
- UniSTS:210235

RH136529 (e-PCR)
- UniSTS:210511

RH136532 (e-PCR)
- UniSTS:210514

RH136545 (e-PCR)
- UniSTS:210527

RH136286 (e-PCR)
- UniSTS:210279

NoName (e-PCR)
- UniSTS:234087

NoName (e-PCR)
- UniSTS:234088

NoName (e-PCR)
- UniSTS:234091

NoName (e-PCR)
- UniSTS:234093

NoName (e-PCR)
- UniSTS:234094

NoName (e-PCR)
- UniSTS:234095

RH136564 (e-PCR)
- UniSTS:210544

RH136324 (e-PCR)
- UniSTS:210315

RH136327 (e-PCR)
- UniSTS:210317

RH136597 (e-PCR)
- UniSTS:210577

RH136345 (e-PCR)
- UniSTS:210335

RH136387 (e-PCR)
- UniSTS:210377

RH136391 (e-PCR)
- UniSTS:210381

RH136401 (e-PCR)
- UniSTS:210391

RH136408 (e-PCR)
- UniSTS:210398

RH136413 (e-PCR)
- UniSTS:210403

RH125483 (e-PCR)
- UniSTS:162302

Homology

Orthologs from OrthoDB

variation

Loc: 9348 replace = a

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
contributes_to cytochrome-c oxidase activity	IBA Inferred from Biological aspect of Ancestor more info
enables cytochrome-c oxidase activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in aerobic electron transport chain	IEA Inferred from Electronic Annotation more info
involved_in mitochondrial electron transport, cytochrome c to oxygen	IBA Inferred from Biological aspect of Ancestor more info
involved_in proton transmembrane transport	IEA Inferred from Electronic Annotation more info
involved_in respiratory chain complex IV assembly	ISO Inferred from Sequence Orthology more info
involved_in respiratory chain complex IV assembly	ISS Inferred from Sequence or Structural Similarity more info

Component	Evidence Code	Pubs
is_active_in mitochondrial inner membrane	IDA Inferred from Direct Assay more info	PubMed
located_in mitochondrial membrane	ISO Inferred from Sequence Orthology more info
located_in mitochondrion	HDA more info	PubMed
is_active_in mitochondrion	IBA Inferred from Biological aspect of Ancestor more info
part_of respiratory chain complex IV	IDA Inferred from Direct Assay more info	PubMed
part_of respiratory chain complex IV	ISO Inferred from Sequence Orthology more info
part_of respiratory chain complex IV	ISS Inferred from Sequence or Structural Similarity more info