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Gadd45b growth arrest and DNA-damage-inducible 45 beta [ Mus musculus (house mouse) ]

Gene ID: 17873, updated on 9-Dec-2024

Summary

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Official Symbol
Gadd45bprovided by MGI
Official Full Name
growth arrest and DNA-damage-inducible 45 betaprovided by MGI
Primary source
MGI:MGI:107776
See related
Ensembl:ENSMUSG00000015312 AllianceGenome:MGI:107776
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Myd118
Summary
Acts upstream of or within negative regulation of protein kinase activity; positive regulation of MAPK cascade; and regulation of cell cycle. Predicted to be active in cytoplasm and nucleus. Is expressed in several structures, including cardiovascular system; embryo mesenchyme; future brain; hindlimb long bone; and sensory organ. Orthologous to human GADD45B (growth arrest and DNA damage inducible beta). [provided by Alliance of Genome Resources, Dec 2024]
Expression
Ubiquitous expression in lung adult (RPKM 41.2), ovary adult (RPKM 20.4) and 25 other tissues See more
Orthologs
human all
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Genomic context

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See Gadd45b in Genome Data Viewer
Location:
10 C1; 10 39.72 cM
Exon count:
4
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 10 NC_000076.7 (80765925..80768038)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 10 NC_000076.6 (80930091..80932204)

Chromosome 10 - NC_000076.7Genomic Context describing neighboring genes Neighboring gene transmembrane protease, serine 9 Neighboring gene translocase of inner mitochondrial membrane 13 Neighboring gene lamin B2 Neighboring gene STARR-positive B cell enhancer ABC_E721 Neighboring gene STARR-seq mESC enhancer starr_27304 Neighboring gene ATP synthase subunit f, mitochondrial-like Neighboring gene STARR-seq mESC enhancer starr_27308 Neighboring gene guanine nucleotide binding protein (G protein), gamma 7 Neighboring gene STARR-seq mESC enhancer starr_27310 Neighboring gene STARR-positive B cell enhancer ABC_E2951 Neighboring gene STARR-positive B cell enhancer ABC_E1807 Neighboring gene STARR-positive B cell enhancer ABC_E10629 Neighboring gene DIRAS family, GTP-binding RAS-like 1 Neighboring gene predicted gene 16099

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Gadd45b deficiency promotes premature senescence and skin aging. Magimaidas A, et al. Oncotarget, 2016 May 10. PMID 27105496, Free PMC Article
  2. Nono induces Gadd45b to mediate DNA repair. Mamontova V, et al. Life Sci Alliance, 2024 Aug. PMID 38843934, Free PMC Article
  3. Neuronal activity-induced Gadd45b promotes epigenetic DNA demethylation and adult neurogenesis. Ma DK, et al. Science, 2009 Feb 20. PMID 19119186, Free PMC Article
  4. Suppression of collagen-induced arthritis in growth arrest and DNA damage-inducible protein 45β-deficient mice. Luo Y, et al. Arthritis Rheum, 2011 Oct. PMID 21702006, Free PMC Article
  5. Gadd45 beta is a pro-survival factor associated with stress-resistant tumors. Engelmann A, et al. Oncogene, 2008 Feb 28. PMID 17891184

See all (98) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Nono induces Gadd45b to mediate DNA repair.
    Title: Nono induces Gadd45b to mediate DNA repair.
  2. Gadd45beta is critical for regulation of type I interferon signaling by facilitating G3BP-mediated stress granule formation.
    Title: Gadd45β is critical for regulation of type I interferon signaling by facilitating G3BP-mediated stress granule formation.
  3. GADD45A and GADD45B as Novel Biomarkers Associated with Chromatin Regulators in Renal Ischemia-Reperfusion Injury.
    Title: GADD45A and GADD45B as Novel Biomarkers Associated with Chromatin Regulators in Renal Ischemia-Reperfusion Injury.
  4. Hepatic Gadd45beta promotes hyperglycemia and glucose intolerance through DNA demethylation of PGC-1alpha.
    Title: Hepatic Gadd45β promotes hyperglycemia and glucose intolerance through DNA demethylation of PGC-1α.
  5. Ablation of Gadd45beta ameliorates the inflammation and renal fibrosis caused by unilateral ureteral obstruction.
    Title: Ablation of Gadd45β ameliorates the inflammation and renal fibrosis caused by unilateral ureteral obstruction.
  6. Gadd45b mediates depressive-like role through DNA demethylation.
    Title: Gadd45b mediates depressive-like role through DNA demethylation.
  7. Non-cell Autonomous OTX2 Homeoprotein Regulates Visual Cortex Plasticity Through Gadd45b/g.
    Title: Non-cell Autonomous OTX2 Homeoprotein Regulates Visual Cortex Plasticity Through Gadd45b/g.
  8. these results indicate that the Gadd45b-regulated TGF-b signaling pathway is involved in wound healing by enhancing epithelial restitution. These results expand the current understanding of the function of Gadd45b and its therapeutic potential in ulcerative colitis.
    Title: Gadd45β promotes regeneration after injury through TGFβ-dependent restitution in experimental colitis.
  9. Gadd45a,b double-mutant mouse embryos display embryonic sublethality, deregulated ZGA gene expression, and developmental arrestrevealing an unexpected role of GADD45 proteins in embryonic two-cell stage regulation
    Title: GADD45 promotes locus-specific DNA demethylation and 2C cycling in embryonic stem cells.
  10. High GADD45B expression is associated with cancer.
    Title: GADD45β Loss Ablates Innate Immunosuppression in Cancer.
Submit: New GeneRIF Correction See all GeneRIFs (54)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in apoptotic process IEA
Inferred from Electronic Annotation
more info
  
involved_in cell differentiation IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within negative regulation of protein kinase activity IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in positive regulation of JNK cascade IEA
Inferred from Electronic Annotation
more info
  
involved_in positive regulation of JNK cascade ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within positive regulation of MAPK cascade IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in positive regulation of apoptotic process IEA
Inferred from Electronic Annotation
more info
  
involved_in positive regulation of apoptotic process ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of p38MAPK cascade IEA
Inferred from Electronic Annotation
more info
  
involved_in positive regulation of p38MAPK cascade ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of cell cycle IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within regulation of cell cycle IDA
Inferred from Direct Assay
more info
 PubMed 
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
  
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleus ISO
Inferred from Sequence Orthology
more info
  
located_in nucleus TAS
Traceable Author Statement
more info
 PubMed 

General protein information

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Preferred Names
growth arrest and DNA damage-inducible protein GADD45 beta
Names
myeloid differentiation primary response gene 118
myeloid differentiation primary response protein MyD118
negative growth regulatory protein MyD118

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_008655.1 → NP_032681.1  growth arrest and DNA damage-inducible protein GADD45 beta

    See identical proteins and their annotated locations for NP_032681.1

    Status: PROVISIONAL

    Source sequence(s)
    X54149
    Consensus CDS
    CCDS24038.1
    UniProtKB/Swiss-Prot
    P22339, Q3U342, Q9R106
    UniProtKB/TrEMBL
    A0A1W2P6W4
    Related
    ENSMUSP00000015456.9, ENSMUST00000015456.10
    Conserved Domains (1) summary
    pfam01248
    Location:21 → 120
    Ribosomal_L7Ae; Ribosomal protein L7Ae/L30e/S12e/Gadd45 family

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000076.7 Reference GRCm39 C57BL/6J

    Range
    80765925..80768038
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P22339.1 GenPept UniProtKB/Swiss-Prot:P22339

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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