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Myh1 myosin, heavy polypeptide 1, skeletal muscle, adult [ Mus musculus (house mouse) ]

Gene ID: 17879, updated on 18-Jun-2024

Summary

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Official Symbol
Myh1provided by MGI
Official Full Name
myosin, heavy polypeptide 1, skeletal muscle, adultprovided by MGI
Primary source
MGI:MGI:1339711
See related
Ensembl:ENSMUSG00000056328 AllianceGenome:MGI:1339711
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
IId; MdMs; IId/x; Myhs-f; Myhsf2; MHC2X/D; Myhs-f2; MHC-2X/D; MYHC-IIX; MyHC-IId/x; MyHC-IIx/d; A530084A17Rik
Summary
Predicted to enable several functions, including ATP binding activity; actin filament binding activity; and calmodulin binding activity. Located in A band and intercalated disc. Is expressed in several structures, including gonad; gut; hemolymphoid system gland; integumental system; and skeletal musculature. Orthologous to human MYH1 (myosin heavy chain 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in mammary gland adult (RPKM 25.2), lung adult (RPKM 11.6) and 2 other tissues See more
Orthologs
human all
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Genomic context

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See Myh1 in Genome Data Viewer
Location:
11 B3; 11 40.59 cM
Exon count:
40
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 11 NC_000077.7 (67090922..67115401)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 11 NC_000077.6 (67200102..67224577)

Chromosome 11 - NC_000077.7Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_29795 Neighboring gene STARR-seq mESC enhancer starr_29796 Neighboring gene predicted gene, 53683 Neighboring gene myosin, heavy polypeptide 2, skeletal muscle, adult Neighboring gene myosin heavy chain gene antisense RNA Neighboring gene myosin, heavy polypeptide 4, skeletal muscle Neighboring gene STARR-seq mESC enhancer starr_29797 Neighboring gene myosin, heavy polypeptide 8, skeletal muscle, perinatal Neighboring gene nuclear encoded tRNA proline 2 (anticodon TGG)

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Oleic acid up-regulates myosin heavy chain (MyHC) 1 expression and increases mitochondrial mass and maximum respiration in C2C12 myoblasts. Watanabe N, et al. Biochem Biophys Res Commun, 2020 Apr 30. PMID 32093891
  2. Slow myosin heavy chain expression in the absence of muscle activity. Agbulut O, et al. Am J Physiol Cell Physiol, 2009 Jan. PMID 18945940
  3. A possible regulatory role for conserved promoter motifs in an adult-specific muscle myosin gene from mouse. Takeda S, et al. J Biol Chem, 1992 Aug 25. PMID 1324916
  4. Endogenous slow and fast myosin dynamics in myofibers isolated from mice expressing GFP-Myh7 and Kusabira Orange-Myh1. Ojima K, et al. Am J Physiol Cell Physiol, 2022 Aug 1. PMID 35759444
  5. Skeletal muscle adaptations in response to voluntary wheel running in myosin heavy chain null mice. Harrison BC, et al. J Appl Physiol (1985), 2002 Jan. PMID 11744674

See all (122) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Simultaneous loss of skeletal muscle myosin heavy chain IIx and IIb causes severe skeletal muscle hypoplasia in postnatal mice.
    Title: Simultaneous loss of skeletal muscle myosin heavy chain IIx and IIb causes severe skeletal muscle hypoplasia in postnatal mice.
  2. Endogenous slow and fast myosin dynamics in myofibers isolated from mice expressing GFP-Myh7 and Kusabira Orange-Myh1.
    Title: Endogenous slow and fast myosin dynamics in myofibers isolated from mice expressing GFP-Myh7 and Kusabira Orange-Myh1.
  3. Oleic acid up-regulates myosin heavy chain (MyHC) 1 expression and increases mitochondrial mass and maximum respiration in C2C12 myoblasts.
    Title: Oleic acid up-regulates myosin heavy chain (MyHC) 1 expression and increases mitochondrial mass and maximum respiration in C2C12 myoblasts.
  4. Data suggest that single muscle immobilization induces a shift of myosin heavy chain (MHC) isoforms composition toward a faster contractile phenotype and decreases the polymorphic profile of single fibres, and that activation of p38 and JNK could be a potential mechanism involved in these contractile phenotype modifications during muscle immobilization.
    Title: Single Muscle Immobilization Decreases Single-Fibre Myosin Heavy Chain Polymorphism: Possible Involvement of p38 and JNK MAP Kinases.
  5. The maintenance of the relative expression of slow MHC-1 protein is independent of neuromuscular activity in mice.
    Title: Slow myosin heavy chain expression in the absence of muscle activity.
  6. p38alpha/beta MAPKs-mediated coactivator recruitment at a proximal MEF-2 site is important for MyHCIId/x gene regulation in skeletal muscle.
    Title: The p38alpha/beta mitogen-activated protein kinases mediate recruitment of CREB-binding protein to preserve fast myosin heavy chain IId/x gene activity in myotubes.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • MGC117705

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
  
enables actin binding IEA
Inferred from Electronic Annotation
more info
  
enables actin filament binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables calmodulin binding IEA
Inferred from Electronic Annotation
more info
  
enables cytoskeletal motor activity IEA
Inferred from Electronic Annotation
more info
  
enables microfilament motor activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables nucleotide binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in muscle contraction IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
located_in A band IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytoplasmic ribonucleoprotein granule ISO
Inferred from Sequence Orthology
more info
  
located_in intercalated disc IDA
Inferred from Direct Assay
more info
 PubMed 
part_of muscle myosin complex ISO
Inferred from Sequence Orthology
more info
 PubMed 
part_of myosin II complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of myosin complex IEA
Inferred from Electronic Annotation
more info
  
is_active_in myosin filament IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
myosin-1
Names
myHC-2x
myosin heavy chain 1
myosin heavy chain 2X
myosin heavy chain, skeletal muscle, adult 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_030679.2 → NP_109604.1  myosin-1

    See identical proteins and their annotated locations for NP_109604.1

    Status: VALIDATED

    Source sequence(s)
    AK041122, BC108329
    Consensus CDS
    CCDS24855.1
    UniProtKB/Swiss-Prot
    Q32P18, Q5SX40
    UniProtKB/TrEMBL
    B2RWX0
    Related
    ENSMUSP00000117569.2, ENSMUST00000124516.8
    Conserved Domains (3) summary
    cd14910
    Location:100 → 773
    MYSc_Myh1_mammals; class II myosin heavy chain 1, motor domain
    pfam01576
    Location:853 → 1930
    Myosin_tail_1; Myosin tail
    pfam02736
    Location:35 → 73
    Myosin_N; Myosin N-terminal SH3-like domain

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000077.7 Reference GRCm39 C57BL/6J

    Range
    67090922..67115401
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017314318.3 → XP_017169807.1  myosin-1 isoform X1

    UniProtKB/Swiss-Prot
    Q32P18, Q5SX40
    UniProtKB/TrEMBL
    B2RWX0
    Related
    ENSMUSP00000018637.9, ENSMUST00000018637.15
    Conserved Domains (3) summary
    cd14910
    Location:100 → 773
    MYSc_Myh1_mammals; class II myosin heavy chain 1, motor domain
    pfam01576
    Location:853 → 1930
    Myosin_tail_1; Myosin tail
    pfam02736
    Location:35 → 73
    Myosin_N; Myosin N-terminal SH3-like domain
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q5SX40.1 GenPept UniProtKB/Swiss-Prot:Q5SX40

Gene LinkOut

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