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Naga N-acetyl galactosaminidase, alpha [ Mus musculus (house mouse) ]

Gene ID: 17939, updated on 9-Dec-2024

Summary

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Official Symbol
Nagaprovided by MGI
Official Full Name
N-acetyl galactosaminidase, alphaprovided by MGI
Primary source
MGI:MGI:1261422
See related
Ensembl:ENSMUSG00000022453 AllianceGenome:MGI:1261422
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Summary
Predicted to enable alpha-N-acetylgalactosaminidase activity; alpha-galactosidase activity; and protein homodimerization activity. Predicted to be involved in several processes, including glycolipid catabolic process; glycoside catabolic process; and oligosaccharide metabolic process. Predicted to be located in lysosome. Predicted to be active in cytoplasm. Is expressed in nervous system and skeleton. Human ortholog(s) of this gene implicated in Kanzaki disease; Schindler disease type 1; angiokeratoma; and neuroaxonal dystrophy. Orthologous to human NAGA (alpha-N-acetylgalactosaminidase). [provided by Alliance of Genome Resources, Dec 2024]
Expression
Ubiquitous expression in colon adult (RPKM 76.1), kidney adult (RPKM 46.4) and 28 other tissues See more
Orthologs
human all
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Genomic context

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See Naga in Genome Data Viewer
Location:
15 E1; 15 38.56 cM
Exon count:
10
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 15 NC_000081.7 (82213746..82222983, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 15 NC_000081.6 (82329532..82338884, complement)

Chromosome 15 - NC_000081.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 52180 Neighboring gene septin 3 Neighboring gene STARR-seq mESC enhancer starr_39292 Neighboring gene WBP2 N-terminal like Neighboring gene STARR-seq mESC enhancer starr_39293 Neighboring gene PH domain containing endocytic trafficking adaptor 2 Neighboring gene nuclear encoded rRNA 5S 41 Neighboring gene single-pass membrane protein with aspartate rich tail 1

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Molecular cloning, structural organization, sequence, chromosomal assignment, and expression of the mouse alpha-N-acetylgalactosaminidase gene. Herrmann T, et al. Gene, 1998 May 12. PMID 9602128
  2. Murine alpha-N-acetylgalactosaminidase: isolation and expression of a full-length cDNA and genomic organization: further evidence of an alpha-galactosidase gene family. Wang AM, et al. Mol Genet Metab, 1998 Oct. PMID 9787108
  3. Use of a modified alpha-N-acetylgalactosaminidase in the development of enzyme replacement therapy for Fabry disease. Tajima Y, et al. Am J Hum Genet, 2009 Nov. PMID 19853240, Free PMC Article
  4. Tnfrsf13c (Baffr) is mis-expressed in tumors with murine leukemia virus insertions at Lvis22. Hentges KE, et al. Genomics, 2002 Aug. PMID 12160734
  5. The transcriptional repressor Blimp1/Prdm1 regulates postnatal reprogramming of intestinal enterocytes. Harper J, et al. Proc Natl Acad Sci U S A, 2011 Jun 28. PMID 21670299, Free PMC Article

See all (25) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Use of a modified Naga in the development of enzyme replacement therapy for Fabry disease is reported.
    Title: Use of a modified alpha-N-acetylgalactosaminidase in the development of enzyme replacement therapy for Fabry disease.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (1) 

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables alpha-N-acetylgalactosaminidase activity ISO
Inferred from Sequence Orthology
more info
  
enables alpha-N-acetylgalactosaminidase activity ISS
Inferred from Sequence or Structural Similarity
more info
  
enables alpha-galactosidase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables protein homodimerization activity IEA
Inferred from Electronic Annotation
more info
  
enables protein homodimerization activity ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in carbohydrate catabolic process ISO
Inferred from Sequence Orthology
more info
  
involved_in carbohydrate catabolic process ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in glycolipid catabolic process ISO
Inferred from Sequence Orthology
more info
  
involved_in glycolipid catabolic process ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in glycoside catabolic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in oligosaccharide metabolic process IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in lysosome IEA
Inferred from Electronic Annotation
more info
  
located_in membrane IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
alpha-N-acetylgalactosaminidase
Names
alpha-galactosidase B
NP_001398349.1
NP_032695.3

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001411420.1 → NP_001398349.1  alpha-N-acetylgalactosaminidase isoform 2

    Status: VALIDATED

    Source sequence(s)
    AC104325
    UniProtKB/TrEMBL
    Q3U6T2

  2. NM_008669.5 → NP_032695.3  alpha-N-acetylgalactosaminidase isoform 1 precursor

    See identical proteins and their annotated locations for NP_032695.3

    Status: VALIDATED

    Source sequence(s)
    AC104325
    Consensus CDS
    CCDS27686.1
    UniProtKB/Swiss-Prot
    O88620, Q8R437, Q8VDK2, Q9QWR8
    UniProtKB/TrEMBL
    Q3U6T2
    Related
    ENSMUSP00000023088.8, ENSMUST00000023088.8
    Conserved Domains (1) summary
    cl07893
    Location:25 → 394
    AmyAc_family; Alpha amylase catalytic domain family

RNA

  1. NR_177249.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC104325

  2. NR_177250.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC104325

  3. NR_177251.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC104325

  4. NR_177252.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC104325

  5. NR_177253.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC104325

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000081.7 Reference GRCm39 C57BL/6J

    Range
    82213746..82222983 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_001355546.1: Suppressed sequence

    Description
    NM_001355546.1: This RefSeq was removed because currently there is support for the transcript but not for the protein.
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9QWR8.2 GenPept UniProtKB/Swiss-Prot:Q9QWR8

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

Chemical Information
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