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Odc1 ornithine decarboxylase, structural 1 [ Mus musculus (house mouse) ]

Gene ID: 18263, updated on 10-Oct-2024

Summary

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Official Symbol
Odc1provided by MGI
Official Full Name
ornithine decarboxylase, structural 1provided by MGI
Primary source
MGI:MGI:97402
See related
Ensembl:ENSMUSG00000011179 AllianceGenome:MGI:97402
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
ODC
Summary
Enables ornithine decarboxylase activity and protein homodimerization activity. Involved in putrescine biosynthetic process from ornithine and regulation of protein catabolic process. Acts upstream of or within kidney development and positive regulation of cell population proliferation. Located in cytosol. Is expressed in several structures, including alimentary system; cardiovascular system; genitourinary system; nervous system; and sensory organ. Used to study atrichia with papular lesions. Orthologous to human ODC1 (ornithine decarboxylase 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Broad expression in liver E14 (RPKM 226.2), liver E14.5 (RPKM 221.0) and 28 other tissues See more
Orthologs
human all
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Genomic context

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See Odc1 in Genome Data Viewer
Location:
12 A1.1- A1.2; 12 8.11 cM
Exon count:
13
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 12 NC_000078.7 (17594906..17601503)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 12 NC_000078.6 (17544808..17551502)

Chromosome 12 - NC_000078.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 36752 Neighboring gene STARR-positive B cell enhancer mm9_chr12:17460788-17461088 Neighboring gene STARR-seq mESC enhancer starr_31660 Neighboring gene STARR-seq mESC enhancer starr_31661 Neighboring gene predicted gene, 46325 Neighboring gene STARR-positive B cell enhancer mm9_chr12:17513963-17514264 Neighboring gene STARR-positive B cell enhancer ABC_E9385 Neighboring gene predicted gene, 22748 Neighboring gene predicted gene, 36862 Neighboring gene predicted gene, 29864

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. ODC1 inhibits the inflammatory response and ROS-induced apoptosis in macrophages. Jiang F, et al. Biochem Biophys Res Commun, 2018 Oct 12. PMID 30217446
  2. Deficiency of ovarian ornithine decarboxylase contributes to aging-related egg aneuploidy in mice. Tao Y, et al. Aging Cell, 2013 Feb. PMID 23061827
  3. Elevated epidermal ornithine decarboxylase activity suppresses contact hypersensitivity. Keough MP, et al. J Invest Dermatol, 2011 Jan. PMID 20844550, Free PMC Article
  4. Structural elements of the ubiquitin-independent proteasome degron of ornithine decarboxylase. Takeuchi J, et al. Biochem J, 2008 Mar 1. PMID 17979831
  5. Sexual dimorphism of ornithine decarboxylase in the mouse adrenal: influence of polyamine deprivation on catecholamine and corticoid levels. Bastida CM, et al. Am J Physiol Endocrinol Metab, 2007 Apr. PMID 17148758

See all (154) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Long-term inhibition of ODC1 in APP/PS1 mice rescues amyloid pathology and switches astrocytes from a reactive to active state.
    Title: Long-term inhibition of ODC1 in APP/PS1 mice rescues amyloid pathology and switches astrocytes from a reactive to active state.
  2. Ornithine decarboxylase, the rate-limiting enzyme of polyamine synthesis, modifies brain pathology in a mouse model of tuberous sclerosis complex.
    Title: Ornithine decarboxylase, the rate-limiting enzyme of polyamine synthesis, modifies brain pathology in a mouse model of tuberous sclerosis complex.
  3. ODC (Ornithine Decarboxylase)-Dependent Putrescine Synthesis Maintains MerTK (MER Tyrosine-Protein Kinase) Expression to Drive Resolution.
    Title: ODC (Ornithine Decarboxylase)-Dependent Putrescine Synthesis Maintains MerTK (MER Tyrosine-Protein Kinase) Expression to Drive Resolution.
  4. Amyloid beta may contribute to M1-like activation by disrupting the balance between ODC and AZ in microglia.
    Title: Aβ stimulates microglial activation through antizyme-dependent downregulation of ornithine decarboxylase.
  5. Findings indicated that ornithine decarboxylase (ODC1) was involved in attenuating the inflammatory response upon stimulation of macrophages, making it a potential therapeutic target for inflammatory diseases.
    Title: ODC1 inhibits the inflammatory response and ROS-induced apoptosis in macrophages.
  6. We demonstrate that ornithine decarboxylase (ODC) regulates M1 activation during Helicobacter pylori and Citrobacter rodentium infection. Deletion of Odc in macrophages resulted in increased inflammation and decreased bacterial persistence in mouse models. The enhanced M1 response was due to alterations in histone modifications, resulting in changes in chromatin structure and up-regulated transcription.
    Title: Ornithine decarboxylase regulates M1 macrophage activation and mucosal inflammation via histone modifications.
  7. these data support the hypothesis that TTP plays a role in the post-transcriptional regulation of the ODC mRNA transcript.
    Title: Destabilization of the ornithine decarboxylase mRNA transcript by the RNA-binding protein tristetraprolin.
  8. Ornithine decarboxylase (ODC) plays a key role in prostate tumorigenesis and that the polyamine pathway is altered as early as high-grade prostate intraepithelial neoplasia (HGPIN).
    Title: Ornithine Decarboxylase Is Sufficient for Prostate Tumorigenesis via Androgen Receptor Signaling.
  9. the Myc-ODC axis plays a critical role in the cellular transformation induced by myeloproliferative neoplasm-associated JAK2 V617F mutant
    Title: Critical roles of Myc-ODC axis in the cellular transformation induced by myeloproliferative neoplasm-associated JAK2 V617F mutant.
  10. Introduction of a fluorine atom at C3 of 3-deazauridine shifts its antimetabolic activity from inhibition of CTP synthetase to inhibition of orotidylate decarboxylase, an early event in the de novo pyrimidine nucleotide biosynthesis pathway.
    Title: Introduction of a fluorine atom at C3 of 3-deazauridine shifts its antimetabolic activity from inhibition of CTP synthetase to inhibition of orotidylate decarboxylase, an early event in the de novo pyrimidine nucleotide biosynthesis pathway.
Submit: New GeneRIF Correction See all GeneRIFs (28)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (5) 
  • Targeted (5)  1 citation

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • MGC103389

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables ornithine decarboxylase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables ornithine decarboxylase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables ornithine decarboxylase activity ISO
Inferred from Sequence Orthology
more info
  
enables protein homodimerization activity IDA
Inferred from Direct Assay
more info
 PubMed 
Process Evidence Code Pubs
acts_upstream_of cell population proliferation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within kidney development IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in polyamine metabolic process ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within positive regulation of cell population proliferation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in putrescine biosynthetic process ISO
Inferred from Sequence Orthology
more info
  
involved_in putrescine biosynthetic process from ornithine IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in putrescine biosynthetic process from ornithine IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in putrescine biosynthetic process from ornithine IEA
Inferred from Electronic Annotation
more info
  
involved_in regulation of protein catabolic process IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in response to virus IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytoplasm IDA
Inferred from Direct Assay
more info
 PubMed 
located_in cytosol IDA
Inferred from Direct Assay
more info
 PubMed 
located_in perinuclear region of cytoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in perinuclear region of cytoplasm ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
ornithine decarboxylase
NP_001396552.1
NP_001396553.1
NP_001396556.1
NP_001396557.1
NP_001396558.1
NP_001396560.1
NP_001396561.1
NP_001396562.1
NP_001396563.1
NP_001396564.1
NP_001396565.1
NP_001396566.1
NP_001396567.1
NP_001396568.1
NP_001396569.1
NP_001396570.1
NP_001396571.1
NP_001396572.1
NP_001396573.1
NP_001396574.1
NP_038642.2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001409623.1 → NP_001396552.1  ornithine decarboxylase isoform 1

    Status: VALIDATED

    Source sequence(s)
    AC163651
    UniProtKB/Swiss-Prot
    P00860, Q61997, Q61998, Q6PB87

  2. NM_001409624.1 → NP_001396553.1  ornithine decarboxylase isoform 1

    Status: VALIDATED

    Source sequence(s)
    AC163651
    UniProtKB/Swiss-Prot
    P00860, Q61997, Q61998, Q6PB87

  3. NM_001409627.1 → NP_001396556.1  ornithine decarboxylase isoform 1

    Status: VALIDATED

    Source sequence(s)
    AC163651
    UniProtKB/Swiss-Prot
    P00860, Q61997, Q61998, Q6PB87

  4. NM_001409628.1 → NP_001396557.1  ornithine decarboxylase isoform 1

    Status: VALIDATED

    Source sequence(s)
    AC163651
    UniProtKB/Swiss-Prot
    P00860, Q61997, Q61998, Q6PB87

  5. NM_001409629.1 → NP_001396558.1  ornithine decarboxylase isoform 1

    Status: VALIDATED

    Source sequence(s)
    AC163651
    UniProtKB/Swiss-Prot
    P00860, Q61997, Q61998, Q6PB87

  6. NM_001409631.1 → NP_001396560.1  ornithine decarboxylase isoform 1

    Status: VALIDATED

    Source sequence(s)
    AC163651
    UniProtKB/Swiss-Prot
    P00860, Q61997, Q61998, Q6PB87

  7. NM_001409632.1 → NP_001396561.1  ornithine decarboxylase isoform 1

    Status: VALIDATED

    Source sequence(s)
    AC163651
    UniProtKB/Swiss-Prot
    P00860, Q61997, Q61998, Q6PB87

  8. NM_001409633.1 → NP_001396562.1  ornithine decarboxylase isoform 1

    Status: VALIDATED

    Source sequence(s)
    AC163651
    UniProtKB/Swiss-Prot
    P00860, Q61997, Q61998, Q6PB87

  9. NM_001409634.1 → NP_001396563.1  ornithine decarboxylase isoform 1

    Status: VALIDATED

    Source sequence(s)
    AC163651
    UniProtKB/Swiss-Prot
    P00860, Q61997, Q61998, Q6PB87

  10. NM_001409635.1 → NP_001396564.1  ornithine decarboxylase isoform 1

    Status: VALIDATED

    Source sequence(s)
    AC163651
    UniProtKB/Swiss-Prot
    P00860, Q61997, Q61998, Q6PB87

  11. NM_001409636.1 → NP_001396565.1  ornithine decarboxylase isoform 1

    Status: VALIDATED

    Source sequence(s)
    AC163651
    UniProtKB/Swiss-Prot
    P00860, Q61997, Q61998, Q6PB87

  12. NM_001409637.1 → NP_001396566.1  ornithine decarboxylase isoform 2

    Status: VALIDATED

    Source sequence(s)
    AC163651

  13. NM_001409638.1 → NP_001396567.1  ornithine decarboxylase isoform 3

    Status: VALIDATED

    Source sequence(s)
    AC163651

  14. NM_001409639.1 → NP_001396568.1  ornithine decarboxylase isoform 4

    Status: VALIDATED

    Source sequence(s)
    AC163651

  15. NM_001409640.1 → NP_001396569.1  ornithine decarboxylase isoform 4

    Status: VALIDATED

    Source sequence(s)
    AC163651

  16. NM_001409641.1 → NP_001396570.1  ornithine decarboxylase isoform 4

    Status: VALIDATED

    Source sequence(s)
    AC163651

  17. NM_001409642.1 → NP_001396571.1  ornithine decarboxylase isoform 4

    Status: VALIDATED

    Source sequence(s)
    AC163651

  18. NM_001409643.1 → NP_001396572.1  ornithine decarboxylase isoform 4

    Status: VALIDATED

    Source sequence(s)
    AC163651

  19. NM_001409644.1 → NP_001396573.1  ornithine decarboxylase isoform 4

    Status: VALIDATED

    Source sequence(s)
    AC163651

  20. NM_001409645.1 → NP_001396574.1  ornithine decarboxylase isoform 4

    Status: VALIDATED

    Source sequence(s)
    AC163651

  21. NM_013614.3 → NP_038642.2  ornithine decarboxylase isoform 1

    See identical proteins and their annotated locations for NP_038642.2

    Status: VALIDATED

    Source sequence(s)
    AC163651
    Consensus CDS
    CCDS25829.1
    UniProtKB/Swiss-Prot
    P00860, Q61997, Q61998, Q6PB87
    UniProtKB/TrEMBL
    Q3TM76
    Related
    ENSMUSP00000128661.2, ENSMUST00000171737.3
    Conserved Domains (1) summary
    cd00622
    Location:37 → 408
    PLPDE_III_ODC; Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Ornithine Decarboxylase

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000078.7 Reference GRCm39 C57BL/6J

    Range
    17594906..17601503
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_001409630.1: Suppressed sequence

    Description
    NM_001409630.1: This RefSeq was removed because currently there is insufficient support for the transcript and the protein.
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P00860.2 GenPept UniProtKB/Swiss-Prot:P00860

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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