P2rx7 purinergic receptor P2X, ligand-gated ion channel, 7 [ Mus musculus (house mouse) ]

Gene ID: 18439, updated on 14-Nov-2024

Summary

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Official Symbol: P2rx7provided by MGI
Official Full Name: purinergic receptor P2X, ligand-gated ion channel, 7provided by MGI
Primary source: MGI:MGI:1339957
See related: Ensembl:ENSMUSG00000029468 AllianceGenome:MGI:1339957
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: P2X7R; P2X(7)
Summary: Enables several functions, including ATP binding activity; extracellularly ATP-gated monoatomic cation channel activity; and lipopolysaccharide binding activity. Involved in bleb assembly; negative regulation of cell volume; and sensory perception of pain. Acts upstream of or within several processes, including phospholipid transport; positive regulation of cytokine production; and positive regulation of secretion. Located in several cellular components, including external side of plasma membrane; neuromuscular junction; and neuronal cell body. Is expressed in brain; cerebral cortex ventricular layer; heart; and metanephros. Orthologous to human P2RX7 (purinergic receptor P2X 7). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Ubiquitous expression in subcutaneous fat pad adult (RPKM 4.7), lung adult (RPKM 4.4) and 28 other tissues See more
Orthologs: human all
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Genomic context

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See P2rx7 in Genome Data Viewer

Location:: 5 F; 5 62.5 cM

Exon count:: 16

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	5	NC_000071.7 (122781990..122830399)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	5	NC_000071.6 (122643927..122692336)

Chromosome 5 - NC_000071.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Inflammatory response and parasite regulation in acute toxoplasmosis: the role of P2X7 receptor in controlling virulent atypical genotype strain of Toxoplasma gondii.
Title: Inflammatory response and parasite regulation in acute toxoplasmosis: the role of P2X7 receptor in controlling virulent atypical genotype strain of Toxoplasma gondii.
P2X7 expression patterns in the developing Fmr1-knockout mouse hippocampus.
Title: P2X7 expression patterns in the developing Fmr1-knockout mouse hippocampus.
P2X7 receptors modulate acquisition of cue fear extinction and contextual background memory generalization in male mice.
Title: P2X7 receptors modulate acquisition of cue fear extinction and contextual background memory generalization in male mice.
Opposing effects of the purinergic P2X7 receptor on seizures in neurons and microglia in male mice.
Title: Opposing effects of the purinergic P2X7 receptor on seizures in neurons and microglia in male mice.
New mechanistic understanding of osteoclast differentiation and bone resorption mediated by P2X7 receptors and PI3K-Akt-GSK3beta signaling.
Title: New mechanistic understanding of osteoclast differentiation and bone resorption mediated by P2X7 receptors and PI3K-Akt-GSK3β signaling.
P2X7R and P2X4R expression of mice submandibular gland in high-fat diet/streptozotocin-induced type 2 diabetes.
Title: P2X7R and P2X4R expression of mice submandibular gland in high-fat diet/streptozotocin-induced type 2 diabetes.
P2X7-Mediated Antigen-Independent Activation of CD8[+] T Cells Promotes Salt-Sensitive Hypertension.
Title: P2X7-Mediated Antigen-Independent Activation of CD8(+) T Cells Promotes Salt-Sensitive Hypertension.
Angiotension II directly bind P2X7 receptor to induce myocardial ferroptosis and remodeling by activating human antigen R.
Title: Angiotension II directly bind P2X7 receptor to induce myocardial ferroptosis and remodeling by activating human antigen R.
The purinergic receptor P2X7 as a modulator of viral vector-mediated antigen cross-presentation.
Title: The purinergic receptor P2X7 as a modulator of viral vector-mediated antigen cross-presentation.
Upregulation of P2X7 Exacerbates Myocardial Ischemia-Reperfusion Injury through Enhancing Inflammation and Apoptosis in Diabetic Mice.
Title: Upregulation of P2X7 Exacerbates Myocardial Ischemia-Reperfusion Injury through Enhancing Inflammation and Apoptosis in Diabetic Mice.

Submit: New GeneRIF Correction See all GeneRIFs (400)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (5)
Spontaneous (2) 1 citation
Targeted (11) 1 citation

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

AI467586 (e-PCR)
- UniSTS:179267

P2rx7 (e-PCR), detects polymorphism
- UniSTS:536438

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables ATP binding	IEA Inferred from Electronic Annotation more info
enables ATP binding	IMP Inferred from Mutant Phenotype more info	PubMed
enables ATP binding	ISO Inferred from Sequence Orthology more info
enables channel activity	IMP Inferred from Mutant Phenotype more info	PubMed
enables channel activity	ISO Inferred from Sequence Orthology more info	PubMed
enables copper ion binding	ISO Inferred from Sequence Orthology more info
enables extracellularly ATP-gated monoatomic cation channel activity	IBA Inferred from Biological aspect of Ancestor more info
enables extracellularly ATP-gated monoatomic cation channel activity	IEA Inferred from Electronic Annotation more info
enables extracellularly ATP-gated monoatomic cation channel activity	IMP Inferred from Mutant Phenotype more info	PubMed
enables extracellularly ATP-gated monoatomic cation channel activity	ISO Inferred from Sequence Orthology more info
enables identical protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables identical protein binding	ISO Inferred from Sequence Orthology more info
enables lipopolysaccharide binding	IDA Inferred from Direct Assay more info	PubMed
enables magnesium ion binding	ISO Inferred from Sequence Orthology more info
enables monoatomic ion channel activity	IEA Inferred from Electronic Annotation more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein serine/threonine kinase activator activity	ISO Inferred from Sequence Orthology more info
enables purinergic nucleotide receptor activity	IEA Inferred from Electronic Annotation more info
enables purinergic nucleotide receptor activity	ISO Inferred from Sequence Orthology more info
enables scaffold protein binding	ISO Inferred from Sequence Orthology more info
enables signaling receptor activity	IMP Inferred from Mutant Phenotype more info	PubMed
enables signaling receptor binding	ISO Inferred from Sequence Orthology more info
enables zinc ion binding	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in ATP export	ISO Inferred from Sequence Orthology more info
acts_upstream_of MAPK cascade	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within NAD transport	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of T cell apoptotic process	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within T cell homeostasis	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of T cell mediated cytotoxicity	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within T cell proliferation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in apoptotic signaling pathway	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within bleb assembly	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in bleb assembly	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in bleb assembly	ISO Inferred from Sequence Orthology more info
involved_in calcium ion transmembrane transport	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within calcium ion transport	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within cell morphogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in cell surface receptor signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
involved_in cell surface receptor signaling pathway	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within cell volume homeostasis	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within cellular response to dsRNA	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within cellular response to organic cyclic compound	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within cellular response to stimulus	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within ceramide biosynthetic process	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within collagen metabolic process	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within defense response to Gram-positive bacterium	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of establishment of localization in cell	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within establishment of localization in cell	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of establishment of localization in cell	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within establishment of localization in cell	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in excitatory postsynaptic potential	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within extrinsic apoptotic signaling pathway	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in extrinsic apoptotic signaling pathway	ISO Inferred from Sequence Orthology more info
acts_upstream_of gamma-aminobutyric acid secretion	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within gene expression	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of glutamate secretion	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within homeostasis of number of cells within a tissue	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within inflammatory response	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of interleukin-1 alpha production	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of interleukin-1 beta production	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of interleukin-6 production	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of lymphocyte apoptotic process	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of macrophage cytokine production	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in membrane depolarization	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within membrane protein ectodomain proteolysis	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of mitochondrial depolarization	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within mitochondrion organization	IDA Inferred from Direct Assay more info	PubMed
involved_in monoatomic cation transmembrane transport	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within monoatomic cation transport	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in monoatomic ion transmembrane transport	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within negative regulation of MAPK cascade	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within negative regulation of bone resorption	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of cell volume	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of cell volume	ISO Inferred from Sequence Orthology more info
involved_in neuronal action potential	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within phagolysosome assembly	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within phospholipid transfer to membrane	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within phospholipid translocation	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within plasma membrane organization	IDA Inferred from Direct Assay more info	PubMed
involved_in plasma membrane phospholipid scrambling	IEA Inferred from Electronic Annotation more info
involved_in plasma membrane phospholipid scrambling	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within pore complex assembly	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in pore complex assembly	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within positive regulation of MAP kinase activity	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within positive regulation of MAPK cascade	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of NLRP3 inflammasome complex assembly	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within positive regulation of T cell apoptotic process	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within positive regulation of T cell mediated cytotoxicity	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within positive regulation of apoptotic process	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of bleb assembly	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of bleb assembly	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within positive regulation of bone mineralization	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of calcium ion transport into cytosol	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of calcium ion transport into cytosol	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within positive regulation of catalytic activity	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of cytoskeleton organization	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within positive regulation of gamma-aminobutyric acid secretion	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of gene expression	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within positive regulation of glutamate secretion	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of glycolytic process	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of glycolytic process	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within positive regulation of interleukin-1 alpha production	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within positive regulation of interleukin-1 beta production	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of interleukin-1 beta production	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within positive regulation of interleukin-6 production	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within positive regulation of lymphocyte apoptotic process	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within positive regulation of macrophage cytokine production	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within positive regulation of mitochondrial depolarization	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of monoatomic ion transmembrane transport	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within positive regulation of ossification	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within positive regulation of prostaglandin secretion	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within positive regulation of protein phosphorylation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of protein phosphorylation	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within positive regulation of protein secretion	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within programmed cell death	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within programmed cell death	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of prostaglandin secretion	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within protein catabolic process	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within protein phosphorylation	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within protein processing	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of protein secretion	IDA Inferred from Direct Assay more info	PubMed
involved_in purinergic nucleotide receptor signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in purinergic nucleotide receptor signaling pathway	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within reactive oxygen species metabolic process	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of presynaptic dense core granule exocytosis	ISO Inferred from Sequence Orthology more info
involved_in regulation of sodium ion transport	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within release of sequestered calcium ion into cytosol	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within response to ATP	IDA Inferred from Direct Assay more info	PubMed
involved_in response to ATP	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within response to ATP	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in response to ATP	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within response to bacterium	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within response to calcium ion	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within response to calcium ion	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within response to electrical stimulus	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within response to fluid shear stress	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within response to lipopolysaccharide	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within response to lipopolysaccharide	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within response to mechanical stimulus	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within response to organic cyclic compound	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within response to xenobiotic stimulus	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within response to zinc ion	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in sensory perception of pain	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within skeletal system morphogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within synaptic vesicle exocytosis	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within vesicle budding from membrane	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
located_in bleb	ISO Inferred from Sequence Orthology more info
located_in cell-cell junction	IDA Inferred from Direct Assay more info	PubMed
located_in cytoplasm	ISO Inferred from Sequence Orthology more info
located_in external side of plasma membrane	IDA Inferred from Direct Assay more info	PubMed
located_in membrane	IDA Inferred from Direct Assay more info	PubMed
located_in membrane	IEA Inferred from Electronic Annotation more info
located_in membrane	ISO Inferred from Sequence Orthology more info
located_in mitochondrion	IEA Inferred from Electronic Annotation more info
located_in neuromuscular junction	IDA Inferred from Direct Assay more info	PubMed
is_active_in neuromuscular junction	IPI Inferred from Physical Interaction more info	PubMed
located_in neuronal cell body	IDA Inferred from Direct Assay more info	PubMed
located_in nuclear envelope	ISO Inferred from Sequence Orthology more info
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in plasma membrane	IDA Inferred from Direct Assay more info	PubMed
located_in plasma membrane	IEA Inferred from Electronic Annotation more info
located_in plasma membrane	IMP Inferred from Mutant Phenotype more info	PubMed
located_in plasma membrane	ISO Inferred from Sequence Orthology more info
located_in plasma membrane	ISS Inferred from Sequence or Structural Similarity more info	PubMed
located_in postsynapse	IEA Inferred from Electronic Annotation more info
located_in presynapse	IEA Inferred from Electronic Annotation more info
part_of protein-containing complex	ISO Inferred from Sequence Orthology more info
located_in synapse	IDA Inferred from Direct Assay more info	PubMed
located_in terminal bouton	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: P2X purinoceptor 7

Names: ATP receptor; P2X7 purinoceptor; P2X7 receptor; P2Z receptor

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001038839.3 → NP_001033928.1 P2X purinoceptor 7 isoform c

See identical proteins and their annotated locations for NP_001033928.1

Status: VALIDATED

Description

Transcript Variant: This variant (3) uses an alternate splice site in the 3' terminal exon and differs in the 3' UTR and the 3' coding region, compared to variant 1. It encodes isoform c, which is shorter and has a distinct C-terminus, compared to isoform a.

Source sequence(s)

AC114632, AJ489296, AK162805, BY752747, FJ436444

Consensus CDS

CCDS51644.1

UniProtKB/TrEMBL

Q3TBP1, Q3UN00

Related

ENSMUSP00000112440.2, ENSMUST00000121489.8

Conserved Domains (1) summary

pfam00864
Location:11 → 397

P2X_receptor; ATP P2X receptor
NM_001038845.3 → NP_001033934.1 P2X purinoceptor 7 isoform b

Status: VALIDATED

Description

Transcript Variant: This variant (2) contains an alternate 3' terminal exon and differs in the 3' UTR and the 3' coding region, compared to variant 1. It encodes isoform b, which is shorter and has a distinct C-terminus, compared to isoform a.

Source sequence(s)

AC114632

Consensus CDS

CCDS19651.1

UniProtKB/TrEMBL

F8WI93, Q3TBP1

Related

ENSMUSP00000031425.9, ENSMUST00000031425.15

Conserved Domains (1) summary

pfam00864
Location:11 → 397

P2X_receptor; ATP P2X receptor
NM_001038887.2 → NP_001033976.1 P2X purinoceptor 7 isoform d

See identical proteins and their annotated locations for NP_001033976.1

Status: VALIDATED

Description

Transcript Variant: This variant (4) lacks several exons and includes an alternate 3' terminal exon, compared to variant 1. It encodes isoform d which is shorter and has a distinct C-terminus, compared to isoform 1.

Source sequence(s)

AC114632, AK144585, BC062808

Consensus CDS

CCDS19653.1

UniProtKB/TrEMBL

Q6P5P0

Related

ENSMUSP00000083425.6, ENSMUST00000086247.6

Conserved Domains (1) summary

cl02993
Location:11 → 125

P2X_receptor; ATP P2X receptor
NM_001284402.2 → NP_001271331.1 P2X purinoceptor 7 isoform e

See identical proteins and their annotated locations for NP_001271331.1

Status: VALIDATED

Description

Transcript Variant: This variant (5) includes an alternate 5' terminal exon and differs in the 5' UTR and the 5' coding region, compared to variant 1. It encodes isoform e, which is shorter and has a distinct N-terminus, compared to isoform a.

Source sequence(s)

AC114632, FJ436444

Consensus CDS

CCDS89983.1

UniProtKB/TrEMBL

C8YIX4, Q8CHP3

Related

ENSMUSP00000158311.2, ENSMUST00000199371.2

Conserved Domains (1) summary

pfam00864
Location:14 → 394

P2X_receptor; ATP P2X receptor
NM_011027.4 → NP_035157.2 P2X purinoceptor 7 isoform a

See identical proteins and their annotated locations for NP_035157.2

Status: VALIDATED

Description

Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (a).

Source sequence(s)

AC114632, AJ489296, BY752747, FJ436444

Consensus CDS

CCDS19652.1

UniProtKB/Swiss-Prot

Q9Z1M0

UniProtKB/TrEMBL

Q8CHP3, Q8CHP4

Related

ENSMUSP00000098303.4, ENSMUST00000100737.10

Conserved Domains (1) summary

pfam00864
Location:11 → 397

P2X_receptor; ATP P2X receptor