Pctp phosphatidylcholine transfer protein [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Pctpprovided by MGI
Official Full Name: phosphatidylcholine transfer proteinprovided by MGI
Primary source: MGI:MGI:107375
See related: Ensembl:ENSMUSG00000020553 AllianceGenome:MGI:107375
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: PC-TP; StarD2
Summary: Predicted to enable phosphatidylcholine binding activity and phosphatidylcholine transporter activity. Involved in negative regulation of cold-induced thermogenesis. Acts upstream of or within cholesterol metabolic process. Located in cytosol. Is expressed in several structures, including genitourinary system; hemolymphoid system gland; intestine; liver; and stomach. Orthologous to human PCTP (phosphatidylcholine transfer protein). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Broad expression in liver E18 (RPKM 11.2), liver adult (RPKM 7.6) and 18 other tissues See more
Orthologs: human all
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Genomic context

Location:: 11 C; 11 54.7 cM

Exon count:: 6

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	11	NC_000077.7 (89873370..89893720, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	11	NC_000077.6 (89982544..90002894, complement)

Chromosome 11 - NC_000077.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

These observations suggest that PC-TP promotes liver injury by mediating the intermembrane transfer of phosphatidylcholines, thus stabilizing more pathogenic microvesicular lipid droplets.
Title: Phosphatidylcholine transfer protein/StarD2 promotes microvesicular steatosis and liver injury in murine experimental steatohepatitis.
Improved glucose tolerance in Pctp(-/-);ob/ob mice in the absence of increases in energy expenditure or core body temperature indicates a direct pathogenic role for Phosphatidylcholine transfer protein in diabetes in leptin deficient mice
Title: Genetic ablation of phosphatidylcholine transfer protein/StarD2 in ob/ob mice improves glucose tolerance without increasing energy expenditure.
Them2 and phosphatidylcholine transfer protein regulate lipid and glucose metabolism
Title: Thioesterase superfamily member 2 (Them2) and phosphatidylcholine transfer protein (PC-TP) interact to promote fatty acid oxidation and control glucose utilization.
PC-TP-THEM2 complex reduces phosphorylation and stability of IRS2 and increases stability of the TSC1-TSC2 complex
Title: Phosphatidylcholine transfer protein interacts with thioesterase superfamily member 2 to attenuate insulin signaling.
Findings support a key role for Pctp in limiting mitochondrial oxidation of fatty acids and thus regulating adaptive thermogenesis in BAT.
Title: Mice lacking Pctp /StarD2 exhibit increased adaptive thermogenesis and enlarged mitochondria in brown adipose tissue.
data support a key biological role for PCTP in the regulation of energy substrate utilization, reflecting increased hepatic triglyceride production in knockout mice.
Title: Regulation of energy substrate utilization and hepatic insulin sensitivity by phosphatidylcholine transfer protein/StarD2.
Yeast two-hybrid screening using libraries prepared from mouse liver and embryo identified Them2 (thioesterase superfamily member 2) and the homeodomain transcription factor Pax3 (paired box gene 3), respectively, as PC-TP-interacting proteins.
Title: Interacting proteins dictate function of the minimal START domain phosphatidylcholine transfer protein/StarD2.
PC-TP modulates the development of atherosclerosis, in part by regulating plasma lipid concentrations
Title: Homozygous disruption of Pctp modulates atherosclerosis in apolipoprotein E-deficient mice.
NZO-derived PC-TP contained a non-synonymous point mutation that resulted in an Arg120His substitution, which was shared by the related NZB/BlNJ and NZW/LacJ mouse strains.
Title: A polymorphism in New Zealand inbred mouse strains that inactivates phosphatidylcholine transfer protein.
In Pctp(-/-) mice, there was an accumulation of small alpha-migrating HDL particles. PC-TP participates in HDL reverse cholesterol transport.
Title: Phosphatidylcholine transfer protein regulates size and hepatic uptake of high-density lipoproteins.

Submit: New GeneRIF Correction See all GeneRIFs (11)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (1)
Spontaneous (1) 1 citation
Targeted (1) 1 citation

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

Pctp (e-PCR), detects polymorphism
- UniSTS:144146

AF114437 (e-PCR)
- UniSTS:180292

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables phosphatidylcholine binding	IBA Inferred from Biological aspect of Ancestor more info
enables phosphatidylcholine binding	ISO Inferred from Sequence Orthology more info
enables phosphatidylcholine binding	ISS Inferred from Sequence or Structural Similarity more info
enables phosphatidylcholine transporter activity	IBA Inferred from Biological aspect of Ancestor more info
enables phosphatidylcholine transporter activity	ISO Inferred from Sequence Orthology more info
enables phosphatidylcholine transporter activity	ISS Inferred from Sequence or Structural Similarity more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within cholesterol metabolic process	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of cold-induced thermogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in phospholipid transport	ISO Inferred from Sequence Orthology more info
involved_in phospholipid transport	ISS Inferred from Sequence or Structural Similarity more info

Component	Evidence Code	Pubs
located_in cytosol	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: phosphatidylcholine transfer protein

Names: START domain-containing protein 2; stAR-related lipid transfer protein 2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001316372.1 → NP_001303301.1 phosphatidylcholine transfer protein isoform 2

Status: VALIDATED

Description

Transcript Variant: This variant (2) lacks an exon in the 3' coding region, which results in a frameshift, compared to variant 1. The encoded isoform (2) has a shorter and distinct C-terminus compared to isoform 1.

Source sequence(s)

AL645695, BC071234, BY144797

Conserved Domains (1) summary

cl14643
Location:8 → 170

SRPBCC; START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily
NM_008796.3 → NP_032822.2 phosphatidylcholine transfer protein isoform 1

See identical proteins and their annotated locations for NP_032822.2

Status: VALIDATED

Description

Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).

Source sequence(s)

AL645695, BB614866, BC071234, BY144797

Consensus CDS

CCDS25238.1

UniProtKB/Swiss-Prot

P53808, Q9QZX0, Q9R058

UniProtKB/TrEMBL

Q5SV41

Related

ENSMUSP00000020864.9, ENSMUST00000020864.9

Conserved Domains (1) summary

cd08910
Location:8 → 210

START_STARD2-like; Lipid-binding START domain of mammalian STARD2 and related proteins